ENSG00000062725

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000083182 ENSG00000062725 No_inf pgwt_inf APPBP2 protein_coding protein_coding 9.384289 8.305629 9.889843 0.3052358 0.2777678 0.2515803 2.922630 3.959404 1.947448 0.2953051 0.4346571 -1.0199481 0.3210417 0.47730 0.195775 -0.281525 0.620961723 0.004017048 FALSE TRUE
ENST00000589341 ENSG00000062725 No_inf pgwt_inf APPBP2 protein_coding nonsense_mediated_decay 9.384289 8.305629 9.889843 0.3052358 0.2777678 0.2515803 1.153370 0.000000 2.526967 0.0000000 0.5361135 7.9869607 0.1148167 0.00000 0.253075 0.253075 0.004017048 0.004017048 FALSE TRUE
MSTRG.13039.2 ENSG00000062725 No_inf pgwt_inf APPBP2 protein_coding   9.384289 8.305629 9.889843 0.3052358 0.2777678 0.2515803 5.107679 4.065167 5.216271 0.3153744 0.5050880 0.3589228 0.5421417 0.48865 0.531100 0.042450 1.000000000 0.004017048 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000062725 E001 24.3878178 0.0031367603 5.907988e-06 0.0002671478 17 60443158 60444668 1511 - 1.215 1.520 1.062
ENSG00000062725 E002 131.5815160 0.0083343562 1.038391e-02 0.0949105236 17 60444669 60447745 3077 - 2.067 2.164 0.327
ENSG00000062725 E003 8.8726884 0.0016405190 7.710101e-01 0.9198648924 17 60447746 60447834 89 - 0.969 1.014 0.167
ENSG00000062725 E004 13.0264323 0.0021342276 9.796277e-01 0.9974136067 17 60451880 60452045 166 - 1.137 1.154 0.061
ENSG00000062725 E005 15.3320597 0.0008971637 7.380115e-01 0.9050772275 17 60454302 60454492 191 - 1.215 1.210 -0.017
ENSG00000062725 E006 7.1000788 0.0020240642 6.701983e-01 0.8724692724 17 60456296 60456381 86 - 0.921 0.896 -0.093
ENSG00000062725 E007 1.9805381 0.0077579553 6.810374e-01 0.8775985869 17 60459507 60460662 1156 - 0.433 0.506 0.369
ENSG00000062725 E008 8.5554818 0.0015606237 5.099844e-01 0.7864579863 17 60460663 60460787 125 - 1.002 0.959 -0.159
ENSG00000062725 E009 0.5866004 0.0152917485 1.586495e-01   17 60460788 60461809 1022 - 0.296 0.095 -1.993
ENSG00000062725 E010 9.7379122 0.0183859703 1.668962e-02 0.1292401701 17 60461810 60461915 106 - 1.137 0.909 -0.836
ENSG00000062725 E011 0.2454678 0.0161407366 9.734816e-01   17 60461916 60461993 78 - 0.095 0.095 0.005
ENSG00000062725 E012 9.8685734 0.0104298490 1.454266e-02 0.1181529871 17 60461994 60462061 68 - 1.137 0.922 -0.787
ENSG00000062725 E013 1.4101617 0.0097322623 3.514992e-02 0.2024485708 17 60462062 60462690 629 - 0.173 0.506 2.176
ENSG00000062725 E014 10.0844247 0.0014846177 2.195995e-03 0.0325554717 17 60464021 60464110 90 - 1.159 0.909 -0.917
ENSG00000062725 E015 0.0000000       17 60464788 60465161 374 -      
ENSG00000062725 E016 8.9912691 0.0161240967 6.147546e-03 0.0670947009 17 60466291 60466350 60 - 1.121 0.853 -0.994
ENSG00000062725 E017 11.5443092 0.0014303636 1.952568e-03 0.0298628686 17 60466351 60466459 109 - 1.208 0.970 -0.861
ENSG00000062725 E018 0.0000000       17 60468439 60468510 72 -      
ENSG00000062725 E019 0.0000000       17 60477469 60477506 38 -      
ENSG00000062725 E020 5.9013695 0.0045285330 4.686757e-02 0.2385666870 17 60479148 60479161 14 - 0.933 0.734 -0.778
ENSG00000062725 E021 8.0304260 0.0020475922 2.464086e-01 0.5730426536 17 60479162 60479271 110 - 1.002 0.909 -0.345
ENSG00000062725 E022 2.2615387 0.0983606883 2.673518e-01 0.5956407728 17 60494466 60494473 8 - 0.392 0.596 1.006
ENSG00000062725 E023 7.5101720 0.0021351472 8.292084e-01 0.9423766344 17 60494474 60494617 144 - 0.908 0.947 0.148
ENSG00000062725 E024 0.0000000       17 60496413 60496441 29 -      
ENSG00000062725 E025 5.9420230 0.0032353625 4.752774e-01 0.7647851346 17 60500399 60500487 89 - 0.787 0.882 0.369
ENSG00000062725 E026 5.1718073 0.0039209059 8.659177e-01 0.9572853187 17 60525794 60525961 168 - 0.770 0.806 0.144
ENSG00000062725 E027 2.0615554 0.0283464303 4.385460e-01 0.7398434783 17 60525962 60526077 116 - 0.537 0.434 -0.508
ENSG00000062725 E028 2.7625319 0.0049621929 1.188442e-01 0.3988930995 17 60526078 60526242 165 - 0.669 0.472 -0.901

Help

Please Click HERE to learn more details about the results from DEXseq.