ENSG00000066427

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340660 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.9240355 0.0000000 1.98983312 0.0000000 1.23657461 7.643736 0.06760833 0.000000 0.146075 0.146075 0.9493242 0.0038573 FALSE TRUE
ENST00000359366 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding nonsense_mediated_decay 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.8938459 0.0000000 1.79343753 0.0000000 0.24157959 7.494606 0.07780000 0.000000 0.150450 0.150450 0.0038573 0.0038573 FALSE TRUE
ENST00000454964 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding retained_intron 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 1.4730376 1.7726485 1.90303627 0.7094607 0.68284799 0.101842 0.10502500 0.114125 0.140900 0.026775 1.0000000 0.0038573 FALSE TRUE
ENST00000502250 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 1.8167015 1.9740122 0.68499700 1.2242596 0.68499700 -1.513342 0.14845000 0.122125 0.069850 -0.052275 0.9928472 0.0038573 FALSE TRUE
ENST00000503767 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.3328055 0.9984165 0.00000000 0.9984165 0.00000000 -6.655948 0.02262500 0.067875 0.000000 -0.067875 0.9932366 0.0038573 FALSE TRUE
ENST00000507965 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding retained_intron 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.3049843 0.9149529 0.00000000 0.4029832 0.00000000 -6.531308 0.01889167 0.056675 0.000000 -0.056675 0.5758239 0.0038573 FALSE TRUE
ENST00000532032 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.6057837 0.0000000 0.48872418 0.0000000 0.48872418 5.640170 0.05685000 0.000000 0.049825 0.049825 0.9928472 0.0038573 FALSE TRUE
ENST00000554350 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding nonsense_mediated_decay 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.6230436 1.8691309 0.00000000 1.3893203 0.00000000 -7.553922 0.03737500 0.112125 0.000000 -0.112125 0.9928472 0.0038573 FALSE FALSE
ENST00000554994 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding nonsense_mediated_decay 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.3318873 0.0000000 0.99566199 0.0000000 0.99566199 6.652002 0.02225000 0.000000 0.066750 0.066750 0.9928472 0.0038573 FALSE TRUE
ENST00000642417 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding_CDS_not_defined 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.4176224 1.0713261 0.06393521 0.2912789 0.06393521 -3.870396 0.02752500 0.066775 0.006525 -0.060250 0.4966824 0.0038573   FALSE
ENST00000642896 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding_CDS_not_defined 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 0.5046699 0.0000000 0.75092184 0.0000000 0.75092184 6.249676 0.03997500 0.000000 0.061125 0.061125 0.9928472 0.0038573   FALSE
ENST00000644486 ENSG00000066427 No_inf pgwt_inf ATXN3 protein_coding protein_coding 13.35279 15.94802 12.50024 0.5831318 1.056229 -0.3511724 2.7052325 3.7020829 1.61050257 1.2417385 0.58098410 -1.195788 0.20270833 0.238275 0.121625 -0.116650 0.9928472 0.0038573 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000066427 E001 0.7698554 0.0138183055 2.715187e-01 5.996274e-01 14 92044496 92044774 279 - 0.118 0.292 1.621
ENSG00000066427 E002 0.1308632 0.0122584991 1.000000e+00   14 92044775 92044797 23 - 0.000 0.076 12.025
ENSG00000066427 E003 0.1308632 0.0122584991 1.000000e+00   14 92044798 92044805 8 - 0.000 0.076 12.025
ENSG00000066427 E004 0.9012292 0.0129221640 1.783698e-01 4.904008e-01 14 92044806 92044958 153 - 0.118 0.333 1.884
ENSG00000066427 E005 0.2450991 0.0162209163 6.947562e-01   14 92046275 92046308 34 - 0.118 0.076 -0.701
ENSG00000066427 E006 0.5073361 0.0304287341 6.212239e-01   14 92047896 92047987 92 - 0.118 0.198 0.884
ENSG00000066427 E007 0.3931610 0.0349446153 2.472256e-01   14 92047988 92047997 10 - 0.000 0.198 13.428
ENSG00000066427 E008 0.5240241 0.0572536987 1.395396e-01   14 92047998 92048039 42 - 0.000 0.247 13.757
ENSG00000066427 E009 0.3936739 0.0160666050 2.434519e-01   14 92048040 92048089 50 - 0.000 0.198 13.456
ENSG00000066427 E010 0.6391319 0.0154004974 4.100376e-01   14 92049603 92049610 8 - 0.118 0.247 1.299
ENSG00000066427 E011 2.6027019 0.0709645236 6.855730e-01 8.800892e-01 14 92049611 92049814 204 - 0.581 0.519 -0.287
ENSG00000066427 E012 1.6713174 0.0133905257 8.043456e-02 3.240776e-01 14 92050341 92050536 196 - 0.211 0.493 1.758
ENSG00000066427 E013 0.5250500 0.0679942930 1.413650e-01   14 92050537 92050646 110 - 0.000 0.247 13.744
ENSG00000066427 E014 1.1640422 0.0109605220 7.623771e-02 3.142201e-01 14 92058319 92058468 150 - 0.118 0.404 2.299
ENSG00000066427 E015 82.9193371 0.0002329574 3.589469e-09 3.360680e-07 14 92058552 92062785 4234 - 1.774 1.959 0.626
ENSG00000066427 E016 22.7251724 0.0010354709 2.699049e-01 5.980346e-01 14 92062786 92063880 1095 - 1.393 1.333 -0.207
ENSG00000066427 E017 9.6030264 0.0016913937 1.094023e-01 3.817862e-01 14 92063881 92064093 213 - 0.896 1.056 0.594
ENSG00000066427 E018 15.7078852 0.0009566833 3.764364e-03 4.764784e-02 14 92064094 92064414 321 - 1.322 1.123 -0.701
ENSG00000066427 E019 0.3594154 0.1597231558 3.527096e-01   14 92070745 92070934 190 - 0.211 0.076 -1.701
ENSG00000066427 E020 2.2698142 0.0972532148 2.483696e-02 1.648908e-01 14 92070935 92070937 3 - 0.704 0.333 -1.816
ENSG00000066427 E021 3.7613233 0.0041838578 2.247805e-02 1.553130e-01 14 92070938 92071010 73 - 0.821 0.544 -1.170
ENSG00000066427 E022 3.7712324 0.0602124820 7.187572e-01 8.967320e-01 14 92071011 92071053 43 - 0.615 0.685 0.299
ENSG00000066427 E023 0.2633236 0.3029052335 5.440338e-01   14 92079415 92079468 54 - 0.000 0.141 12.632
ENSG00000066427 E024 0.2456120 0.0162829698 6.949286e-01   14 92080541 92080567 27 - 0.118 0.076 -0.701
ENSG00000066427 E025 0.2623781 0.0160655220 4.710914e-01   14 92080953 92080964 12 - 0.000 0.141 12.938
ENSG00000066427 E026 3.8496791 0.0244767780 6.337525e-01 8.540881e-01 14 92080965 92080987 23 - 0.704 0.649 -0.232
ENSG00000066427 E027 6.2265181 0.0510531359 7.208225e-01 8.973684e-01 14 92080988 92081022 35 - 0.860 0.830 -0.116
ENSG00000066427 E028 6.2219676 0.0023768110 7.331617e-01 9.028212e-01 14 92081023 92081057 35 - 0.860 0.830 -0.116
ENSG00000066427 E029 4.2581188 0.0035254373 7.748106e-01 9.216544e-01 14 92081058 92081061 4 - 0.676 0.718 0.173
ENSG00000066427 E030 8.2797246 0.0140004174 2.712091e-01 5.991557e-01 14 92082300 92082342 43 - 1.016 0.909 -0.399
ENSG00000066427 E031 12.0772788 0.0012206382 5.791461e-02 2.697837e-01 14 92082343 92082466 124 - 1.186 1.041 -0.524
ENSG00000066427 E032 10.1048978 0.0029541893 9.070819e-01 9.726181e-01 14 92083126 92083235 110 - 1.028 1.025 -0.011
ENSG00000066427 E033 4.8273586 0.0031465837 4.497259e-01 7.476681e-01 14 92083236 92083258 23 - 0.800 0.718 -0.329
ENSG00000066427 E034 0.2630299 0.2030027979 5.231657e-01   14 92083417 92083503 87 - 0.000 0.141 12.714
ENSG00000066427 E035 7.7703347 0.0019708468 1.737672e-01 4.833940e-01 14 92088730 92088817 88 - 1.002 0.877 -0.472
ENSG00000066427 E036 0.3591269 0.2376715892 3.660933e-01   14 92090379 92090567 189 - 0.211 0.076 -1.700
ENSG00000066427 E037 7.6267216 0.0020956210 8.494425e-02 3.336059e-01 14 92093252 92093318 67 - 1.016 0.854 -0.608
ENSG00000066427 E038 0.1316618 0.0123953976 1.000000e+00   14 92093379 92093551 173 - 0.000 0.076 12.025
ENSG00000066427 E039 0.3941868 0.0411604866 2.480438e-01   14 92093552 92093618 67 - 0.000 0.198 13.420
ENSG00000066427 E040 0.7887317 0.0172766715 4.260709e-02 2.266900e-01 14 92093619 92093745 127 - 0.000 0.333 14.302
ENSG00000066427 E041 5.8305945 0.0049522424 4.979175e-01 7.791076e-01 14 92093746 92093831 86 - 0.860 0.791 -0.268
ENSG00000066427 E042 0.1141751 0.0111250620 3.168191e-01   14 92093832 92093850 19 - 0.118 0.000 -13.718
ENSG00000066427 E043 4.2520976 0.0082404731 2.260025e-02 1.557923e-01 14 92096093 92096134 42 - 0.860 0.589 -1.116
ENSG00000066427 E044 2.4535314 0.0579198300 3.243506e-01 6.486524e-01 14 92096135 92096137 3 - 0.615 0.465 -0.701
ENSG00000066427 E045 0.0000000       14 92096277 92096673 397 -      
ENSG00000066427 E046 8.0198036 0.0017844160 1.612588e-01 4.643530e-01 14 92096674 92096838 165 - 1.016 0.888 -0.479
ENSG00000066427 E047 2.9612188 0.0067742368 4.227658e-01 7.282607e-01 14 92106529 92106621 93 - 0.647 0.544 -0.460

Help

Please Click HERE to learn more details about the results from DEXseq.