ENSG00000099875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250896 ENSG00000099875 No_inf pgwt_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 72.25955 1.234886 2.629775 0.7028009 39.535052 32.817430 43.049207 0.5454319 1.490069 0.3914200 0.67349167 0.740900 0.596750 -0.144150 9.716538e-01 1.995238e-05 FALSE TRUE
ENST00000309340 ENSG00000099875 No_inf pgwt_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 72.25955 1.234886 2.629775 0.7028009 6.805399 0.000000 11.283747 0.0000000 1.841757 10.1413085 0.10146667 0.000000 0.159325 0.159325 1.995238e-05 1.995238e-05 FALSE TRUE
ENST00000589509 ENSG00000099875 No_inf pgwt_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 72.25955 1.234886 2.629775 0.7028009 4.152676 1.523212 7.018131 0.9973013 2.831307 2.1965838 0.06338333 0.033075 0.096950 0.063875 9.928472e-01 1.995238e-05 FALSE FALSE
ENST00000591142 ENSG00000099875 No_inf pgwt_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 72.25955 1.234886 2.629775 0.7028009 3.866601 6.532214 3.724132 1.4877237 2.346024 -0.8090061 0.07139167 0.145400 0.049175 -0.096225 9.253180e-01 1.995238e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000099875 E001 0.0000000       19 2037465 2037470 6 -      
ENSG00000099875 E002 1.2446132 0.0136553986 2.348825e-01 0.5599723136 19 2037471 2037472 2 - 0.260 0.440 1.100
ENSG00000099875 E003 97.0893890 0.0001517379 1.122800e-03 0.0195618464 19 2037473 2037829 357 - 1.945 2.039 0.315
ENSG00000099875 E004 147.1118382 0.0001191636 1.674366e-07 0.0000111525 19 2037830 2038247 418 - 2.110 2.231 0.405
ENSG00000099875 E005 255.9355433 0.0001267101 3.294128e-02 0.1945833599 19 2038248 2039411 1164 - 2.392 2.426 0.112
ENSG00000099875 E006 49.0976561 0.0002940258 2.626660e-03 0.0370453923 19 2039412 2039630 219 - 1.637 1.762 0.421
ENSG00000099875 E007 61.8633148 0.0002238797 7.205047e-01 0.8972252509 19 2039631 2039856 226 - 1.791 1.802 0.035
ENSG00000099875 E008 2.1125753 0.0082019864 1.459913e-01 0.4418777658 19 2039857 2039954 98 - 0.386 0.594 1.030
ENSG00000099875 E009 5.7899212 0.0024118205 6.251383e-01 0.8500280918 19 2039955 2040131 177 - 0.854 0.797 -0.222
ENSG00000099875 E010 2.9751772 0.0048692866 1.819127e-01 0.4945722821 19 2040132 2040133 2 - 0.671 0.484 -0.848
ENSG00000099875 E011 33.1081971 0.0019443381 8.980156e-01 0.9695353928 19 2040134 2040177 44 - 1.529 1.532 0.013
ENSG00000099875 E012 2.5504092 0.0056852289 8.638171e-01 0.9565613886 19 2040178 2040308 131 - 0.539 0.560 0.100
ENSG00000099875 E013 5.0087991 0.0089544714 5.040869e-01 0.7831876993 19 2040309 2041039 731 - 0.741 0.817 0.304
ENSG00000099875 E014 66.7922237 0.0002201896 2.629553e-01 0.5910402772 19 2041040 2041204 165 - 1.848 1.804 -0.149
ENSG00000099875 E015 65.3945333 0.0060076701 3.173129e-01 0.6428604326 19 2041840 2042034 195 - 1.843 1.789 -0.179
ENSG00000099875 E016 0.4914489 0.1112347926 7.356727e-01   19 2042035 2042140 106 - 0.149 0.200 0.515
ENSG00000099875 E017 39.5913350 0.0003536433 8.183546e-03 0.0813847400 19 2042427 2042522 96 - 1.659 1.529 -0.446
ENSG00000099875 E018 40.7317219 0.0045795098 1.888008e-01 0.5031283073 19 2042607 2042662 56 - 1.650 1.575 -0.254
ENSG00000099875 E019 2.1908611 0.1206077158 8.400414e-01 0.9469858170 19 2042663 2042765 103 - 0.484 0.524 0.193
ENSG00000099875 E020 53.2611399 0.0114954127 2.354337e-01 0.5605342912 19 2042766 2042870 105 - 1.763 1.690 -0.247
ENSG00000099875 E021 45.1053568 0.0003172810 5.326419e-03 0.0605997120 19 2043124 2043197 74 - 1.714 1.585 -0.439
ENSG00000099875 E022 37.4204803 0.0003898905 7.121279e-02 0.3028197905 19 2043503 2043582 80 - 1.621 1.529 -0.314
ENSG00000099875 E023 34.4941857 0.0046644021 7.529141e-02 0.3121861716 19 2046186 2046283 98 - 1.592 1.485 -0.366
ENSG00000099875 E024 28.7216151 0.0007924214 2.332633e-04 0.0058245605 19 2046367 2046460 94 - 1.554 1.338 -0.745
ENSG00000099875 E025 12.7611280 0.0011434447 1.838040e-02 0.1373607802 19 2046461 2046468 8 - 1.214 1.016 -0.714
ENSG00000099875 E026 3.9727652 0.0042623406 5.922117e-01 0.8335308546 19 2046522 2046603 82 - 0.724 0.654 -0.292
ENSG00000099875 E027 23.0686216 0.0008542917 7.605529e-03 0.0775839972 19 2046604 2046691 88 - 1.448 1.275 -0.599
ENSG00000099875 E028 22.0874957 0.0094208878 1.362442e-01 0.4276139395 19 2050801 2050947 147 - 1.408 1.295 -0.392
ENSG00000099875 E029 18.9924374 0.0235699774 8.840015e-01 0.9638063060 19 2051096 2051217 122 - 1.306 1.289 -0.062
ENSG00000099875 E030 4.9873050 0.0140534511 7.232114e-01 0.8984461018 19 2051218 2051244 27 - 0.757 0.797 0.161

Help

Please Click HERE to learn more details about the results from DEXseq.