ENSG00000100427

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311597 ENSG00000100427 No_inf pgwt_inf MLC1 protein_coding protein_coding 6.324705 10.58189 4.526289 0.3216491 0.2389891 -1.223375 3.3807137 3.229106 3.1141751 1.1480317 0.3825048 -0.05212017 0.66310000 0.31090 0.696275 0.385375 0.9295208195 0.0007666325 FALSE TRUE
ENST00000395876 ENSG00000100427 No_inf pgwt_inf MLC1 protein_coding protein_coding 6.324705 10.58189 4.526289 0.3216491 0.2389891 -1.223375 1.0542586 2.843207 0.3195690 0.8120231 0.3195690 -3.11393176 0.11072500 0.26570 0.066475 -0.199225 0.6621547920 0.0007666325 FALSE TRUE
MSTRG.19599.3 ENSG00000100427 No_inf pgwt_inf MLC1 protein_coding   6.324705 10.58189 4.526289 0.3216491 0.2389891 -1.223375 1.4383708 4.315112 0.0000000 0.4092967 0.0000000 -8.75659379 0.13538333 0.40615 0.000000 -0.406150 0.0007666325 0.0007666325 FALSE TRUE
MSTRG.19599.5 ENSG00000100427 No_inf pgwt_inf MLC1 protein_coding   6.324705 10.58189 4.526289 0.3216491 0.2389891 -1.223375 0.3110508 0.000000 0.8660715 0.0000000 0.3450635 6.45297664 0.06899167 0.00000 0.189100 0.189100 0.1901709940 0.0007666325 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000100427 E001 0.1311489 0.0123395532 1.0000000000   22 50059391 50059395 5 - 0.000 0.064 8.175
ENSG00000100427 E002 51.5924802 0.0003087141 0.0001247267 0.003520066 22 50059396 50060414 1019 - 1.550 1.708 0.538
ENSG00000100427 E003 19.6095034 0.0008130472 0.4290488508 0.732664457 22 50060415 50060876 462 - 1.303 1.250 -0.186
ENSG00000100427 E004 22.9337801 0.0006787725 0.7905527683 0.927720323 22 50060877 50061460 584 - 1.342 1.325 -0.058
ENSG00000100427 E005 9.9764175 0.0014461474 0.8719331360 0.959638598 22 50061461 50061657 197 - 0.983 0.998 0.056
ENSG00000100427 E006 5.7037962 0.0027928326 0.6276072821 0.850795714 22 50064034 50064198 165 - 0.740 0.798 0.231
ENSG00000100427 E007 7.1406356 0.0021000172 0.3964723163 0.708952664 22 50068433 50068555 123 - 0.929 0.840 -0.341
ENSG00000100427 E008 2.2956971 0.0144074404 0.4717057436 0.762222197 22 50070527 50070538 12 - 0.398 0.510 0.579
ENSG00000100427 E009 2.4272121 0.0075677398 0.3859785405 0.700754337 22 50070539 50070541 3 - 0.398 0.531 0.679
ENSG00000100427 E010 3.9161185 0.0041898437 0.9135818665 0.974366030 22 50070542 50070583 42 - 0.641 0.655 0.061
ENSG00000100427 E011 0.1308632 0.0123364229 1.0000000000   22 50072745 50072815 71 - 0.000 0.064 10.178
ENSG00000100427 E012 6.6823251 0.0024921557 0.9678563659 0.993195737 22 50074216 50074332 117 - 0.845 0.840 -0.019
ENSG00000100427 E013 0.0000000       22 50074608 50074684 77 -      
ENSG00000100427 E014 4.2603707 0.0496160392 0.5495019402 0.810635072 22 50076841 50076912 72 - 0.740 0.655 -0.353
ENSG00000100427 E015 5.3191857 0.0028502517 0.0476985466 0.240834893 22 50077401 50077502 102 - 0.910 0.685 -0.891
ENSG00000100427 E016 5.2190347 0.0035566799 0.1464194276 0.442492414 22 50079918 50080019 102 - 0.867 0.699 -0.672
ENSG00000100427 E017 4.5377757 0.0030896830 0.9342921909 0.981826667 22 50080344 50080397 54 - 0.709 0.699 -0.044
ENSG00000100427 E018 4.9617746 0.0033881340 0.0918055222 0.348038845 22 50083084 50083173 90 - 0.867 0.670 -0.792
ENSG00000100427 E019 5.7909170 0.0026966113 0.0145167132 0.118032507 22 50084726 50084961 236 - 0.966 0.699 -1.044
ENSG00000100427 E020 1.0320143 0.0120722533 0.2529127750 0.580062541 22 50085139 50085354 216 - 0.138 0.326 1.579
ENSG00000100427 E021 1.6049463 0.0098143607 0.2217887800 0.545895733 22 50085355 50085458 104 - 0.512 0.326 -1.006

Help

Please Click HERE to learn more details about the results from DEXseq.