ENSG00000100596

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216484 ENSG00000100596 No_inf pgwt_inf SPTLC2 protein_coding protein_coding 13.84525 7.973341 20.63355 1.672333 3.238506 1.370627 6.942298 6.25975806 6.805032 0.12366717 0.2186236 0.1203107 0.612950 0.866600 0.356450 -0.510150 0.189044820 0.000781611 FALSE TRUE
ENST00000554365 ENSG00000100596 No_inf pgwt_inf SPTLC2 protein_coding retained_intron 13.84525 7.973341 20.63355 1.672333 3.238506 1.370627 2.443010 0.00000000 5.789823 0.00000000 1.1938801 9.1798651 0.127425 0.000000 0.280525 0.280525 0.000781611 0.000781611 FALSE FALSE
ENST00000554901 ENSG00000100596 No_inf pgwt_inf SPTLC2 protein_coding protein_coding 13.84525 7.973341 20.63355 1.672333 3.238506 1.370627 2.579087 0.08569194 4.080557 0.08569194 0.5370001 5.4177560 0.163875 0.006600 0.207050 0.200450 0.045577711 0.000781611 FALSE TRUE
ENST00000556607 ENSG00000100596 No_inf pgwt_inf SPTLC2 protein_coding nonsense_mediated_decay 13.84525 7.973341 20.63355 1.672333 3.238506 1.370627 1.762587 1.48101662 3.806744 1.48101662 2.3032077 1.3560461 0.086875 0.114125 0.146500 0.032375 0.992847247 0.000781611 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000100596 E001 0.0000000       14 77505997 77506002 6 -      
ENSG00000100596 E002 209.8575031 0.0001079744 2.137349e-26 1.080603e-23 14 77506003 77512340 6338 - 2.248 2.395 0.489
ENSG00000100596 E003 11.3351194 0.0110717005 2.206458e-02 1.531538e-01 14 77512341 77512403 63 - 1.180 0.960 -0.799
ENSG00000100596 E004 15.7519724 0.0030339085 9.789622e-02 3.606467e-01 14 77518038 77518167 130 - 1.278 1.151 -0.451
ENSG00000100596 E005 13.9754636 0.0017997741 1.832940e-01 4.962943e-01 14 77521446 77521581 136 - 1.221 1.115 -0.377
ENSG00000100596 E006 0.0000000       14 77521582 77521615 34 -      
ENSG00000100596 E007 0.3596939 0.0166529827 7.674154e-01   14 77535600 77536005 406 - 0.155 0.107 -0.613
ENSG00000100596 E008 6.5508765 0.0027827710 3.277908e-02 1.939317e-01 14 77552096 77552119 24 - 0.971 0.739 -0.898
ENSG00000100596 E009 11.8097552 0.0011986363 2.342395e-05 8.775467e-04 14 77552120 77552222 103 - 1.243 0.872 -1.356
ENSG00000100596 E010 0.1138060 0.0111084765 7.067323e-01   14 77554758 77554965 208 - 0.084 0.000 -10.231
ENSG00000100596 E011 8.6755848 0.0114301516 1.014788e-02 9.364843e-02 14 77555300 77555319 20 - 1.092 0.820 -1.019
ENSG00000100596 E012 22.1973801 0.0047382449 5.576362e-04 1.144286e-02 14 77555320 77555519 200 - 1.460 1.222 -0.828
ENSG00000100596 E013 11.7197780 0.0045946812 2.320970e-02 1.582062e-01 14 77557041 77557146 106 - 1.186 0.986 -0.725
ENSG00000100596 E014 0.1139502 0.0112040758 7.065410e-01   14 77557147 77557321 175 - 0.084 0.000 -10.230
ENSG00000100596 E015 8.8746588 0.0016666199 1.003204e-01 3.650055e-01 14 77562396 77562489 94 - 1.060 0.903 -0.584
ENSG00000100596 E016 0.7373243 0.0285002798 7.437517e-01 9.079011e-01 14 77568984 77570383 1400 - 0.215 0.265 0.387
ENSG00000100596 E017 11.9171580 0.0011603508 1.676749e-01 4.742888e-01 14 77570384 77570508 125 - 1.161 1.044 -0.420
ENSG00000100596 E018 0.0000000       14 77570509 77571010 502 -      
ENSG00000100596 E019 0.1138060 0.0111084765 7.067323e-01   14 77575732 77576766 1035 - 0.084 0.000 -10.231
ENSG00000100596 E020 13.9603091 0.0010518477 1.257201e-01 4.110099e-01 14 77576767 77576915 149 - 1.226 1.106 -0.430
ENSG00000100596 E021 0.2620121 0.0160885866 1.618432e-01   14 77576916 77577160 245 - 0.000 0.193 10.824
ENSG00000100596 E022 0.0000000       14 77578766 77578954 189 -      
ENSG00000100596 E023 10.5659278 0.0013641441 9.035794e-01 9.714935e-01 14 77578955 77579109 155 - 1.068 1.055 -0.047
ENSG00000100596 E024 0.0000000       14 77588871 77588929 59 -      
ENSG00000100596 E025 11.7547252 0.0017017899 5.525629e-02 2.627617e-01 14 77597186 77597380 195 - 1.174 1.010 -0.591
ENSG00000100596 E026 6.3677606 0.0022471049 1.323151e-03 2.224923e-02 14 77616448 77616637 190 - 1.000 0.639 -1.420

Help

Please Click HERE to learn more details about the results from DEXseq.