ENSG00000104946

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000594996 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding nonsense_mediated_decay 39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 1.314215 3.0475195 0.0000000 1.0362560 0.0000000 -8.2562179 0.03542500 0.082850 0.000000 -0.082850 2.129479e-01 1.199045e-06   FALSE
ENST00000598789 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding protein_coding_CDS_not_defined 39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 2.757434 5.3785244 0.7522223 2.1207430 0.4490119 -2.8216066 0.07190000 0.139925 0.015650 -0.124275 9.300585e-01 1.199045e-06 FALSE FALSE
ENST00000600354 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding retained_intron 39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 3.817348 2.3700768 5.1548051 0.3189252 0.3801790 1.1177058 0.09475000 0.062700 0.113475 0.050775 9.928472e-01 1.199045e-06 FALSE TRUE
MSTRG.15523.11 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding   39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 3.546780 1.9253491 5.1174783 0.1653998 0.1361231 1.4056557 0.08818333 0.051050 0.113025 0.061975 8.754380e-01 1.199045e-06 FALSE TRUE
MSTRG.15523.15 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding   39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 7.770075 5.6718967 9.3581808 0.9060094 0.6625457 0.7213963 0.19538333 0.152325 0.205600 0.053275 9.928472e-01 1.199045e-06 TRUE FALSE
MSTRG.15523.16 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding   39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 1.968077 0.2057426 4.0746239 0.2057426 0.5861361 4.2428200 0.04703333 0.005275 0.089475 0.084200 7.083137e-02 1.199045e-06 FALSE TRUE
MSTRG.15523.17 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding   39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 5.930603 3.9033963 6.8448570 0.3996644 0.7074207 0.8087054 0.15017500 0.105000 0.149600 0.044600 9.928472e-01 1.199045e-06 FALSE TRUE
MSTRG.15523.2 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding   39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 7.940333 3.4262556 13.9593074 0.4851715 0.2498289 2.0233513 0.19302500 0.092275 0.308000 0.215725 2.325992e-01 1.199045e-06 TRUE TRUE
MSTRG.15523.5 ENSG00000104946 No_inf pgwt_inf TBC1D17 protein_coding   39.69503 37.52763 45.50186 1.022456 1.922604 0.2779048 3.494532 8.3723634 0.0000000 1.2820253 0.0000000 -9.7112133 0.09345000 0.221750 0.000000 -0.221750 1.199045e-06 1.199045e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000104946 E001 0.0000000       19 49877662 49877662 1 +      
ENSG00000104946 E002 0.0000000       19 49877663 49877663 1 +      
ENSG00000104946 E003 0.0000000       19 49877664 49877665 2 +      
ENSG00000104946 E004 0.0000000       19 49877666 49877693 28 +      
ENSG00000104946 E005 0.0000000       19 49877694 49877701 8 +      
ENSG00000104946 E006 0.0000000       19 49877702 49877744 43 +      
ENSG00000104946 E007 0.3932413 0.0273354365 5.166971e-02   19 49878076 49878142 67 + 0.000 0.275 11.029
ENSG00000104946 E008 0.3932413 0.0273354365 5.166971e-02   19 49878143 49878186 44 + 0.000 0.275 13.594
ENSG00000104946 E009 0.0000000       19 49878187 49878205 19 +      
ENSG00000104946 E010 0.0000000       19 49878206 49878241 36 +      
ENSG00000104946 E011 0.0000000       19 49878498 49878549 52 +      
ENSG00000104946 E012 0.0000000       19 49878550 49878572 23 +      
ENSG00000104946 E013 44.9121120 0.0008236108 1.062857e-02 9.653179e-02 19 49878573 49879322 750 + 1.705 1.593 -0.381
ENSG00000104946 E014 7.6298256 0.0020110913 6.000370e-02 2.753629e-01 19 49879323 49879504 182 + 1.008 0.819 -0.716
ENSG00000104946 E015 4.3320889 0.0039959190 5.437962e-01 8.074730e-01 19 49879505 49880278 774 + 0.755 0.683 -0.295
ENSG00000104946 E016 18.0093864 0.0018065647 5.776974e-02 2.693215e-01 19 49880279 49880402 124 + 1.212 1.346 0.469
ENSG00000104946 E017 42.2826289 0.0010194145 8.021911e-16 1.843512e-13 19 49880403 49881267 865 + 1.769 1.368 -1.369
ENSG00000104946 E018 7.6334936 0.0032904888 4.186164e-04 9.190518e-03 19 49881268 49881273 6 + 0.739 1.096 1.354
ENSG00000104946 E019 8.6473562 0.0171899247 3.534466e-04 8.056276e-03 19 49881274 49881475 202 + 0.770 1.153 1.435
ENSG00000104946 E020 13.1678454 0.0010491699 4.259253e-10 4.586343e-08 19 49881476 49882040 565 + 1.318 0.756 -2.072
ENSG00000104946 E021 1.5164043 0.1095822165 8.317792e-02 3.295949e-01 19 49882041 49882152 112 + 0.511 0.201 -1.932
ENSG00000104946 E022 4.2286571 0.0033674921 5.989831e-03 6.591546e-02 19 49882153 49882241 89 + 0.840 0.485 -1.523
ENSG00000104946 E023 6.6497382 0.0020802979 2.622173e-02 1.706327e-01 19 49882242 49882265 24 + 0.971 0.733 -0.923
ENSG00000104946 E024 19.2424706 0.0092616420 7.974660e-02 3.225469e-01 19 49882266 49882400 135 + 1.238 1.374 0.472
ENSG00000104946 E025 18.6739339 0.0007934443 6.077496e-13 9.988544e-11 19 49882764 49882892 129 + 0.999 1.499 1.769
ENSG00000104946 E026 10.5420697 0.0229238713 2.342646e-07 1.507415e-05 19 49882973 49883076 104 + 0.723 1.284 2.090
ENSG00000104946 E027 4.2386687 0.0519572923 9.253933e-01 9.790427e-01 19 49883077 49883277 201 + 0.723 0.709 -0.057
ENSG00000104946 E028 3.7636524 0.0442943828 9.335665e-01 9.815449e-01 19 49883278 49883406 129 + 0.669 0.683 0.058
ENSG00000104946 E029 1.5346566 0.0097488239 1.762803e-01 4.874222e-01 19 49883407 49883413 7 + 0.483 0.275 -1.209
ENSG00000104946 E030 4.3753910 0.0112754214 4.019421e-02 2.193411e-01 19 49883414 49883586 173 + 0.827 0.562 -1.110
ENSG00000104946 E031 0.0000000       19 49883587 49883650 64 +      
ENSG00000104946 E032 2.3687137 0.0060443149 1.353180e-01 4.263453e-01 19 49883651 49883745 95 + 0.608 0.393 -1.057
ENSG00000104946 E033 0.0000000       19 49884253 49884369 117 +      
ENSG00000104946 E034 1.0434956 0.0112988836 4.955929e-02 2.462472e-01 19 49884370 49884458 89 + 0.420 0.112 -2.472
ENSG00000104946 E035 24.5817446 0.0006745061 5.451491e-02 2.609966e-01 19 49884459 49884559 101 + 1.350 1.466 0.398
ENSG00000104946 E036 13.6474587 0.0011214147 3.079882e-06 1.518093e-04 19 49884560 49884658 99 + 1.296 0.906 -1.411
ENSG00000104946 E037 30.3747210 0.0004828111 1.203829e-12 1.863162e-10 19 49884659 49884758 100 + 1.282 1.665 1.319
ENSG00000104946 E038 10.0500986 0.0014029010 9.154471e-02 3.474968e-01 19 49885172 49885764 593 + 1.101 0.951 -0.550
ENSG00000104946 E039 23.1187716 0.0086434129 4.744020e-02 2.400773e-01 19 49886551 49887475 925 + 1.436 1.297 -0.484
ENSG00000104946 E040 26.2760297 0.0041182630 6.393654e-13 1.047573e-10 19 49887476 49887573 98 + 1.172 1.628 1.580
ENSG00000104946 E041 5.2898338 0.0026968171 2.784570e-03 3.869678e-02 19 49887574 49887717 144 + 0.921 0.562 -1.472
ENSG00000104946 E042 23.3283481 0.0049258947 3.063640e-13 5.263313e-11 19 49887718 49887834 117 + 1.094 1.590 1.732
ENSG00000104946 E043 13.7644358 0.0009847572 2.144906e-06 1.100140e-04 19 49887835 49888156 322 + 1.300 0.906 -1.427
ENSG00000104946 E044 3.2710002 0.0602342068 9.563398e-01 9.893082e-01 19 49888157 49888174 18 + 0.630 0.627 -0.013
ENSG00000104946 E045 5.9978155 0.0023764699 3.050181e-01 6.318904e-01 19 49888175 49888230 56 + 0.888 0.778 -0.429
ENSG00000104946 E046 21.8093877 0.0033657657 2.049991e-03 3.097011e-02 19 49888231 49888317 87 + 1.253 1.457 0.707
ENSG00000104946 E047 78.7098355 0.0034350742 1.101230e-07 7.671900e-06 19 49888424 49889653 1230 + 1.979 1.772 -0.695

Help

Please Click HERE to learn more details about the results from DEXseq.