ENSG00000105397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000525621 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding protein_coding 114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 11.346309 0.000000 11.221981 0.0000000 1.9890505 10.1333966 0.09229167 0.000000 0.078375 0.078375 4.105416e-05 4.105416e-05 FALSE TRUE
ENST00000529739 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding retained_intron 114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 5.740366 6.087186 5.193947 0.5837409 0.4988500 -0.2285373 0.05456667 0.075400 0.036025 -0.039375 9.582090e-01 4.105416e-05 TRUE TRUE
ENST00000530220 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding retained_intron 114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 7.322514 6.267416 10.583133 0.6117176 1.8820116 0.7548867 0.06495000 0.075925 0.072875 -0.003050 1.000000e+00 4.105416e-05 FALSE FALSE
ENST00000699356 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding retained_intron 114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 17.919409 14.726396 30.771629 1.1724365 1.1711168 1.0626859 0.15522500 0.181300 0.213025 0.031725 9.928472e-01 4.105416e-05 TRUE TRUE
ENST00000699361 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding retained_intron 114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 20.477257 19.124520 21.598628 1.5716619 1.6114585 0.1754298 0.18705833 0.231750 0.149075 -0.082675 9.928472e-01 4.105416e-05 FALSE FALSE
ENST00000699362 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding nonsense_mediated_decay 114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 5.257786 0.000000 9.881836 0.0000000 5.7269625 9.9500945 0.03751667 0.000000 0.066000 0.066000 9.928472e-01 4.105416e-05 FALSE FALSE
MSTRG.14503.1 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding   114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 9.666121 4.625857 18.026872 1.6124000 1.0535024 1.9600411 0.07850833 0.054875 0.125200 0.070325 9.928472e-01 4.105416e-05 FALSE TRUE
MSTRG.14503.3 ENSG00000105397 No_inf pgwt_inf TYK2 protein_coding   114.3943 82.37596 145.4163 5.434632 5.328883 0.819818 6.806374 6.373137 8.097658 0.3984766 0.8088898 0.3450196 0.06165833 0.078975 0.055500 -0.023475 9.928472e-01 4.105416e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000105397 E001 0.1138060 0.0112114741 1.000000e+00   19 10350448 10350457 10 - 0.072 0.000 -9.192
ENSG00000105397 E002 1.8936189 0.0337564548 4.142284e-01 7.217739e-01 19 10350458 10350532 75 - 0.500 0.367 -0.701
ENSG00000105397 E003 2.3682231 0.0060463756 3.350060e-01 6.580865e-01 19 10350533 10350534 2 - 0.569 0.425 -0.702
ENSG00000105397 E004 4.2009269 0.0032532323 9.171243e-01 9.756266e-01 19 10350535 10350544 10 - 0.711 0.698 -0.055
ENSG00000105397 E005 4.8238783 0.0028996524 7.579657e-01 9.140493e-01 19 10350545 10350548 4 - 0.741 0.777 0.146
ENSG00000105397 E006 4.8238783 0.0028996524 7.579657e-01 9.140493e-01 19 10350549 10350550 2 - 0.741 0.777 0.146
ENSG00000105397 E007 5.0688331 0.0028171791 6.928706e-01 8.831827e-01 19 10350551 10350554 4 - 0.755 0.801 0.183
ENSG00000105397 E008 5.4113584 0.0028575802 9.534321e-01 9.886103e-01 19 10350555 10350556 2 - 0.794 0.801 0.025
ENSG00000105397 E009 10.1818217 0.0013816299 6.732342e-01 8.736295e-01 19 10350557 10350568 12 - 1.052 1.013 -0.142
ENSG00000105397 E010 12.5860728 0.0010595591 7.004127e-01 8.870836e-01 19 10350569 10350576 8 - 1.134 1.102 -0.117
ENSG00000105397 E011 86.3497098 0.0001783774 8.374441e-01 9.458679e-01 19 10350577 10350747 171 - 1.932 1.925 -0.024
ENSG00000105397 E012 84.5170563 0.0002427803 3.557001e-01 6.756861e-01 19 10350748 10350852 105 - 1.932 1.900 -0.107
ENSG00000105397 E013 117.2745126 0.0001494404 1.751125e-01 4.853306e-01 19 10350853 10350946 94 - 2.046 2.084 0.128
ENSG00000105397 E014 69.2581746 0.0002216064 1.562183e-01 4.575352e-01 19 10350947 10350968 22 - 1.814 1.866 0.176
ENSG00000105397 E015 92.8828937 0.0001628324 1.229826e-01 4.061625e-01 19 10351052 10351143 92 - 1.941 1.990 0.164
ENSG00000105397 E016 39.3524655 0.0006336198 7.250963e-01 8.992725e-01 19 10351144 10351162 19 - 1.587 1.605 0.059
ENSG00000105397 E017 15.3550797 0.0008470526 1.692584e-06 9.039487e-05 19 10351163 10351484 322 - 1.031 1.385 1.258
ENSG00000105397 E018 75.1726855 0.0002402229 7.767966e-01 9.225285e-01 19 10352434 10352551 118 - 1.866 1.876 0.033
ENSG00000105397 E019 14.9806568 0.0009115469 3.023401e-02 1.853352e-01 19 10352552 10352785 234 - 1.122 1.285 0.577
ENSG00000105397 E020 39.5259168 0.0004220664 4.242838e-01 7.292538e-01 19 10352926 10352957 32 - 1.611 1.571 -0.136
ENSG00000105397 E021 30.0564636 0.0103602392 1.717090e-01 4.802605e-01 19 10352958 10352967 10 - 1.515 1.419 -0.328
ENSG00000105397 E022 80.4216371 0.0001818844 1.192530e-01 3.994297e-01 19 10352968 10353098 131 - 1.919 1.864 -0.185
ENSG00000105397 E023 49.9197971 0.0016120420 3.303223e-03 4.343693e-02 19 10353099 10353527 429 - 1.639 1.772 0.452
ENSG00000105397 E024 81.1404531 0.0001796243 1.018138e-03 1.821361e-02 19 10353528 10353646 119 - 1.944 1.827 -0.393
ENSG00000105397 E025 63.4109534 0.0002737132 2.390822e-05 8.906608e-04 19 10353647 10353813 167 - 1.728 1.889 0.544
ENSG00000105397 E026 54.6792762 0.0005138144 6.121136e-03 6.687520e-02 19 10353814 10353929 116 - 1.687 1.801 0.386
ENSG00000105397 E027 41.5342030 0.0027056354 8.401288e-03 8.275947e-02 19 10353930 10354041 112 - 1.560 1.695 0.458
ENSG00000105397 E028 108.9615659 0.0049548750 2.509932e-01 5.780074e-01 19 10354042 10354234 193 - 2.047 2.000 -0.155
ENSG00000105397 E029 63.0223640 0.0006390610 1.226747e-01 4.055066e-01 19 10354512 10354609 98 - 1.818 1.755 -0.212
ENSG00000105397 E030 81.6076690 0.0002113970 2.849070e-01 6.126933e-01 19 10356568 10356718 151 - 1.919 1.882 -0.126
ENSG00000105397 E031 21.8864436 0.0014278213 2.101118e-05 8.018688e-04 19 10356719 10357763 1045 - 1.222 1.495 0.948
ENSG00000105397 E032 75.3501030 0.0001848883 5.773437e-01 8.253626e-01 19 10357764 10357918 155 - 1.879 1.858 -0.069
ENSG00000105397 E033 53.5390654 0.0006775772 3.292609e-01 6.530842e-01 19 10358003 10358138 136 - 1.741 1.698 -0.146
ENSG00000105397 E034 3.2897142 0.0510779574 4.085880e-01 7.176041e-01 19 10358334 10358610 277 - 0.569 0.698 0.561
ENSG00000105397 E035 57.2608969 0.0002401903 7.301639e-01 9.016796e-01 19 10359175 10359302 128 - 1.759 1.745 -0.049
ENSG00000105397 E036 1.8846120 0.0077101954 1.446288e-02 1.177759e-01 19 10360962 10361073 112 - 0.279 0.636 1.883
ENSG00000105397 E037 0.2625250 0.0161437480 9.372453e-02   19 10361305 10361510 206 - 0.000 0.221 11.749
ENSG00000105397 E038 48.7242200 0.0002928451 2.521167e-01 5.790968e-01 19 10361511 10361598 88 - 1.704 1.652 -0.176
ENSG00000105397 E039 48.4730115 0.0028352239 1.376455e-02 1.144767e-01 19 10361770 10361836 67 - 1.727 1.601 -0.426
ENSG00000105397 E040 52.2790448 0.0002626543 1.729368e-01 4.821456e-01 19 10361837 10361920 84 - 1.737 1.677 -0.202
ENSG00000105397 E041 36.0493140 0.0021473569 9.474955e-01 9.867358e-01 19 10361921 10361955 35 - 1.556 1.559 0.011
ENSG00000105397 E042 64.6553506 0.0002402938 9.298862e-01 9.803718e-01 19 10362078 10362181 104 - 1.804 1.807 0.010
ENSG00000105397 E043 0.5082151 0.0153098674 1.092336e-01   19 10362182 10362214 33 - 0.072 0.300 2.468
ENSG00000105397 E044 72.3426571 0.0002001308 7.748241e-02 3.172519e-01 19 10362264 10362456 193 - 1.878 1.812 -0.222
ENSG00000105397 E045 28.5483332 0.0025771630 7.406009e-01 9.062364e-01 19 10362549 10362579 31 - 1.467 1.446 -0.071
ENSG00000105397 E046 40.5653556 0.0010269175 6.112007e-01 8.432184e-01 19 10362580 10362657 78 - 1.597 1.622 0.084
ENSG00000105397 E047 4.1380297 0.1119839401 3.727553e-01 6.906836e-01 19 10364146 10364517 372 - 0.646 0.777 0.542
ENSG00000105397 E048 1.5870412 0.0204894965 4.271315e-01 7.310647e-01 19 10364518 10364613 96 - 0.354 0.476 0.661
ENSG00000105397 E049 60.7457969 0.0002372516 3.111743e-01 6.373153e-01 19 10364614 10364771 158 - 1.763 1.803 0.134
ENSG00000105397 E050 0.7533039 0.0139289975 1.204197e-01 4.016462e-01 19 10364772 10364850 79 - 0.134 0.367 1.883
ENSG00000105397 E051 63.8734069 0.0002515107 7.909121e-01 9.277524e-01 19 10364851 10365048 198 - 1.804 1.794 -0.036
ENSG00000105397 E052 7.5268637 0.0051838340 3.525114e-03 4.558690e-02 19 10365049 10365516 468 - 0.782 1.078 1.120
ENSG00000105397 E053 109.1291655 0.0007888268 4.013438e-01 7.124584e-01 19 10365517 10365898 382 - 2.040 2.013 -0.091
ENSG00000105397 E054 78.0262398 0.0020667403 6.962431e-01 8.844397e-01 19 10366417 10366580 164 - 1.892 1.876 -0.054
ENSG00000105397 E055 26.8111165 0.0041967852 9.229162e-01 9.781021e-01 19 10368055 10368062 8 - 1.431 1.436 0.017
ENSG00000105397 E056 44.1655694 0.0055647840 3.323711e-01 6.559159e-01 19 10368063 10368121 59 - 1.622 1.674 0.175
ENSG00000105397 E057 36.9682789 0.0004730705 1.757485e-01 4.865092e-01 19 10368122 10368179 58 - 1.540 1.608 0.231
ENSG00000105397 E058 20.5180003 0.0007097497 4.052974e-01 7.151783e-01 19 10368180 10368202 23 - 1.299 1.354 0.191
ENSG00000105397 E059 29.7025263 0.0021097648 1.109173e-01 3.848216e-01 19 10368295 10368371 77 - 1.510 1.414 -0.331
ENSG00000105397 E060 29.5184229 0.0008178795 3.191183e-02 1.909673e-01 19 10368372 10368418 47 - 1.517 1.391 -0.435
ENSG00000105397 E061 0.1308632 0.0122686135 2.799839e-01   19 10368419 10368531 113 - 0.000 0.125 10.749
ENSG00000105397 E062 2.7433868 0.0052444228 6.372427e-01 8.557720e-01 19 10368532 10368741 210 - 0.589 0.522 -0.309
ENSG00000105397 E063 2.1054661 0.0065182729 8.469466e-02 3.329638e-01 19 10369757 10369877 121 - 0.569 0.300 -1.439
ENSG00000105397 E064 64.6084470 0.0002248006 3.961039e-01 7.086000e-01 19 10378214 10378426 213 - 1.818 1.784 -0.113
ENSG00000105397 E065 34.4574240 0.0040766085 3.076440e-01 6.340149e-01 19 10379615 10379689 75 - 1.560 1.500 -0.208
ENSG00000105397 E066 40.9090745 0.0010944235 2.173821e-01 5.405126e-01 19 10379690 10379779 90 - 1.633 1.571 -0.213
ENSG00000105397 E067 40.4893027 0.0003384385 3.768102e-01 6.943196e-01 19 10380380 10380509 130 - 1.622 1.579 -0.149
ENSG00000105397 E068 7.2112910 0.0022192087 9.829077e-01 9.986305e-01 19 10380510 10380608 99 - 0.905 0.902 -0.010

Help

Please Click HERE to learn more details about the results from DEXseq.