ENSG00000109466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226725 ENSG00000109466 No_inf pgwt_inf KLHL2 protein_coding protein_coding 27.04969 29.84154 22.09222 0.8229694 0.7980301 -0.4336142 9.951780 10.1053545 11.102209 1.6732232 0.9336582 0.1355987 0.37685000 0.336800 0.500125 0.163325 0.99060377 0.03014208 FALSE TRUE
ENST00000421009 ENSG00000109466 No_inf pgwt_inf KLHL2 protein_coding protein_coding 27.04969 29.84154 22.09222 0.8229694 0.7980301 -0.4336142 1.583553 2.5323155 0.000000 2.5323155 0.0000000 -7.9899993 0.05294167 0.082925 0.000000 -0.082925 0.99359071 0.03014208 FALSE TRUE
ENST00000509028 ENSG00000109466 No_inf pgwt_inf KLHL2 protein_coding protein_coding_CDS_not_defined 27.04969 29.84154 22.09222 0.8229694 0.7980301 -0.4336142 1.413103 2.0986146 0.000000 1.5128400 0.0000000 -7.7201516 0.04742500 0.067550 0.000000 -0.067550 0.99284725 0.03014208 TRUE TRUE
MSTRG.22513.11 ENSG00000109466 No_inf pgwt_inf KLHL2 protein_coding   27.04969 29.84154 22.09222 0.8229694 0.7980301 -0.4336142 7.366337 11.2818246 4.362258 3.8192277 1.6505433 -1.3688283 0.26836667 0.383800 0.202000 -0.181800 0.99284725 0.03014208 FALSE TRUE
MSTRG.22513.13 ENSG00000109466 No_inf pgwt_inf KLHL2 protein_coding   27.04969 29.84154 22.09222 0.8229694 0.7980301 -0.4336142 3.358864 0.2969158 4.992888 0.2969158 0.4183659 4.0268467 0.13273333 0.010700 0.225325 0.214625 0.03014208 0.03014208 TRUE TRUE
MSTRG.22513.14 ENSG00000109466 No_inf pgwt_inf KLHL2 protein_coding   27.04969 29.84154 22.09222 0.8229694 0.7980301 -0.4336142 1.568554 2.7905017 0.000000 1.7008029 0.0000000 -8.1295415 0.05343333 0.092600 0.000000 -0.092600 0.99284725 0.03014208 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000109466 E001 0.1308632 0.0123142836 0.706157756   4 165207561 165207574 14 + 0.000 0.084 10.232
ENSG00000109466 E002 0.3587636 0.1844446799 0.477265858   4 165207575 165207608 34 + 0.194 0.084 -1.395
ENSG00000109466 E003 0.6223729 0.1712380862 0.887087965   4 165207609 165207613 5 + 0.194 0.215 0.191
ENSG00000109466 E004 7.1785912 0.0019308442 0.051919325 0.25332622 4 165207614 165207822 209 + 1.011 0.816 -0.739
ENSG00000109466 E005 8.5582617 0.0034429130 0.112855081 0.38831178 4 165207823 165207902 80 + 1.056 0.906 -0.560
ENSG00000109466 E006 0.0000000       4 165209400 165209462 63 +      
ENSG00000109466 E007 0.0000000       4 165209893 165210018 126 +      
ENSG00000109466 E008 0.0000000       4 165210019 165210035 17 +      
ENSG00000109466 E009 0.1315150 0.0124418375 0.706082099   4 165210036 165210180 145 + 0.000 0.084 12.263
ENSG00000109466 E010 0.1315150 0.0124418375 0.706082099   4 165218182 165218215 34 + 0.000 0.084 12.263
ENSG00000109466 E011 0.2281253 0.0153671628 0.162425042   4 165219644 165219722 79 + 0.194 0.000 -14.593
ENSG00000109466 E012 8.4751960 0.0099790910 0.355243225 0.67533644 4 165219934 165220000 67 + 1.023 0.928 -0.353
ENSG00000109466 E013 6.9032693 0.0024552066 0.635743257 0.85494853 4 165220001 165220059 59 + 0.919 0.870 -0.188
ENSG00000109466 E014 0.1141751 0.0112179403 0.407563428   4 165223938 165223984 47 + 0.107 0.000 -13.663
ENSG00000109466 E015 0.2281253 0.0153671628 0.162425042   4 165223985 165224057 73 + 0.194 0.000 -14.593
ENSG00000109466 E016 3.4061899 0.0043451048 0.149597890 0.44731067 4 165228807 165228913 107 + 0.511 0.704 0.853
ENSG00000109466 E017 0.0000000       4 165238776 165238777 2 +      
ENSG00000109466 E018 14.5779784 0.0012176195 0.713148947 0.89357814 4 165238778 165238899 122 + 1.201 1.173 -0.100
ENSG00000109466 E019 0.0000000       4 165240348 165240464 117 +      
ENSG00000109466 E020 14.3357589 0.0010602763 0.730204236 0.90167957 4 165263197 165263256 60 + 1.193 1.166 -0.095
ENSG00000109466 E021 12.5079826 0.0105726669 0.959699704 0.99023535 4 165263257 165263359 103 + 1.126 1.120 -0.021
ENSG00000109466 E022 15.3534157 0.0068630560 0.956260434 0.98930820 4 165294359 165294468 110 + 1.208 1.203 -0.020
ENSG00000109466 E023 19.3007132 0.0007688646 0.325272226 0.64968455 4 165297609 165297725 117 + 1.258 1.324 0.229
ENSG00000109466 E024 26.5931084 0.0005374342 0.776258462 0.92215698 4 165299507 165299656 150 + 1.442 1.425 -0.058
ENSG00000109466 E025 21.7458492 0.0135858943 0.670487483 0.87262494 4 165305608 165305725 118 + 1.327 1.362 0.122
ENSG00000109466 E026 38.6018021 0.0003840838 0.600625695 0.83794948 4 165310553 165310750 198 + 1.574 1.598 0.083
ENSG00000109466 E027 0.1139502 0.0111526727 0.407651831   4 165310751 165310752 2 + 0.107 0.000 -13.663
ENSG00000109466 E028 25.5135265 0.0006184918 0.992307211 1.00000000 4 165311464 165311565 102 + 1.415 1.415 0.000
ENSG00000109466 E029 27.8485627 0.0005161897 0.260296889 0.58792995 4 165313238 165313366 129 + 1.488 1.425 -0.216
ENSG00000109466 E030 31.8290470 0.0005113838 0.340071399 0.66210776 4 165314026 165314166 141 + 1.537 1.487 -0.171
ENSG00000109466 E031 39.8953827 0.0004127782 0.109245387 0.38153951 4 165317826 165317969 144 + 1.646 1.572 -0.252
ENSG00000109466 E032 5.2824605 0.0045953699 0.466992029 0.75879951 4 165321312 165321375 64 + 0.839 0.756 -0.328
ENSG00000109466 E033 174.2921866 0.0001920250 0.004376449 0.05304587 4 165322032 165323156 1125 + 2.201 2.256 0.183

Help

Please Click HERE to learn more details about the results from DEXseq.