ENSG00000125726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245903 ENSG00000125726 No_inf pgwt_inf CD70 protein_coding protein_coding 32.24319 29.50191 34.21015 1.907065 1.644998 0.2135486 20.055269 19.341202 19.1573971 1.9591499 2.4526907 -0.01376873 0.62859167 0.652275 0.556925 -0.095350 0.99284725 0.02624111 FALSE TRUE
ENST00000423145 ENSG00000125726 No_inf pgwt_inf CD70 protein_coding protein_coding 32.24319 29.50191 34.21015 1.907065 1.644998 0.2135486 5.455880 3.219511 6.2358214 0.4966527 1.7133264 0.95157560 0.16697500 0.113625 0.176650 0.063025 0.99284725 0.02624111 FALSE TRUE
MSTRG.14392.4 ENSG00000125726 No_inf pgwt_inf CD70 protein_coding   32.24319 29.50191 34.21015 1.907065 1.644998 0.2135486 4.044901 1.326613 7.7249482 1.3266127 2.7803149 2.53281009 0.11795833 0.044000 0.234325 0.190325 0.72067713 0.02624111   FALSE
MSTRG.14392.6 ENSG00000125726 No_inf pgwt_inf CD70 protein_coding   32.24319 29.50191 34.21015 1.907065 1.644998 0.2135486 1.869149 4.762562 0.2622218 0.5585713 0.2622218 -4.13190960 0.06085833 0.161450 0.006850 -0.154600 0.02624111 0.02624111   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000125726 E001 11.4080364 0.0673184069 9.022854e-01 0.9710053051 19 6583183 6583478 296 - 1.114 1.071 -0.154
ENSG00000125726 E002 0.4748797 0.0420069916 4.212790e-01   19 6585839 6585922 84 - 0.222 0.104 -1.306
ENSG00000125726 E003 0.4733020 0.0190663747 4.194601e-01   19 6585923 6585931 9 - 0.222 0.104 -1.306
ENSG00000125726 E004 34.8782209 0.0005248759 9.693843e-01 0.9938628034 19 6585932 6586153 222 - 1.552 1.557 0.016
ENSG00000125726 E005 34.7357703 0.0007243361 4.154014e-01 0.7226846264 19 6586154 6586274 121 - 1.533 1.573 0.136
ENSG00000125726 E006 29.4737885 0.0091945615 8.380959e-01 0.9460965761 19 6586275 6586405 131 - 1.488 1.479 -0.032
ENSG00000125726 E007 12.1818002 0.0012839356 9.482025e-01 0.9868088246 19 6590103 6590136 34 - 1.121 1.118 -0.011
ENSG00000125726 E008 23.7374473 0.0013945616 1.794583e-01 0.4918656340 19 6590841 6591055 215 - 1.428 1.354 -0.257
ENSG00000125726 E009 5.5084775 0.0035810725 7.837813e-02 0.3193232228 19 6591056 6591162 107 - 0.897 0.703 -0.769
ENSG00000125726 E010 2.2162420 0.0067283230 1.583135e-05 0.0006338031 19 6592203 6592415 213 - 0.087 0.725 4.279
ENSG00000125726 E011 1.8043308 0.0085093758 1.805793e-03 0.0281368778 19 6592416 6592575 160 - 0.160 0.627 2.864
ENSG00000125726 E012 0.0000000       19 6593577 6593623 47 -      
ENSG00000125726 E013 0.1316618 0.0123801676 4.465424e-01   19 6603941 6604103 163 - 0.000 0.104 8.852

Help

Please Click HERE to learn more details about the results from DEXseq.