ENSG00000125753

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245932 ENSG00000125753 No_inf pgwt_inf VASP protein_coding protein_coding 404.9122 197.7595 493.5823 7.581666 5.213516 1.3195 272.959372 143.447475 334.31504 2.7613838 3.489392 1.2206283 0.68645000 0.728400 0.677650 -0.050750 9.928472e-01 2.242772e-08 FALSE TRUE
ENST00000592139 ENSG00000125753 No_inf pgwt_inf VASP protein_coding protein_coding 404.9122 197.7595 493.5823 7.581666 5.213516 1.3195 69.094181 6.090402 95.82543 6.0904019 3.467222 3.9735830 0.14055000 0.027775 0.194125 0.166350 8.597435e-02 2.242772e-08   FALSE
ENST00000705986 ENSG00000125753 No_inf pgwt_inf VASP protein_coding protein_coding 404.9122 197.7595 493.5823 7.581666 5.213516 1.3195 22.781588 13.809808 26.46038 0.8922142 3.213223 0.9376414 0.05910000 0.070350 0.053500 -0.016850 9.928472e-01 2.242772e-08 FALSE TRUE
ENST00000705987 ENSG00000125753 No_inf pgwt_inf VASP protein_coding protein_coding 404.9122 197.7595 493.5823 7.581666 5.213516 1.3195 7.054031 14.559036 0.00000 3.0697752 0.000000 -10.5086898 0.02843333 0.072875 0.000000 -0.072875 2.242772e-08 2.242772e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000125753 E001 0.5879532 4.706737e-02 5.922931e-01   19 45506579 45506887 309 + 0.222 0.133 -0.892
ENSG00000125753 E002 2.2447256 9.677717e-03 1.209731e-02 1.052094e-01 19 45507144 45507178 35 + 0.336 0.695 1.760
ENSG00000125753 E003 13.8125074 1.219572e-03 3.498010e-02 2.018647e-01 19 45507179 45507478 300 + 1.085 1.253 0.597
ENSG00000125753 E004 10.0990392 1.353478e-03 4.386596e-01 7.399174e-01 19 45507479 45507487 9 + 1.000 1.071 0.260
ENSG00000125753 E005 10.0821263 1.327844e-03 5.844556e-01 8.292557e-01 19 45507488 45507490 3 + 1.007 1.058 0.185
ENSG00000125753 E006 45.4777533 8.278455e-04 2.331212e-01 5.585860e-01 19 45507491 45507505 15 + 1.666 1.608 -0.198
ENSG00000125753 E007 50.8798282 1.819503e-03 1.038535e-01 3.712729e-01 19 45507506 45507509 4 + 1.720 1.641 -0.269
ENSG00000125753 E008 109.5741366 1.438231e-03 1.749133e-05 6.867934e-04 19 45507510 45507561 52 + 2.070 1.917 -0.515
ENSG00000125753 E009 363.9184296 9.948828e-05 5.788210e-10 6.084612e-08 19 45507562 45507776 215 + 2.576 2.468 -0.360
ENSG00000125753 E010 243.0398159 6.709615e-05 1.311717e-02 1.106528e-01 19 45517663 45517750 88 + 2.384 2.332 -0.172
ENSG00000125753 E011 254.4768003 6.500735e-05 1.325710e-01 4.218969e-01 19 45517751 45517834 84 + 2.397 2.366 -0.101
ENSG00000125753 E012 172.5891239 2.586930e-04 1.726834e-01 4.818687e-01 19 45517929 45517963 35 + 2.230 2.196 -0.115
ENSG00000125753 E013 319.8626130 7.566739e-05 6.353212e-05 2.034177e-03 19 45517964 45518094 131 + 2.509 2.436 -0.244
ENSG00000125753 E014 217.4170003 7.471851e-05 1.740881e-04 4.590980e-03 19 45521322 45521406 85 + 2.346 2.262 -0.279
ENSG00000125753 E015 171.0349063 9.399300e-05 1.402552e-04 3.863823e-03 19 45522168 45522217 50 + 2.246 2.150 -0.321
ENSG00000125753 E016 293.4505325 3.705428e-04 2.354014e-03 3.413983e-02 19 45522340 45522522 183 + 2.469 2.407 -0.206
ENSG00000125753 E017 102.8555052 1.613979e-04 3.726945e-01 6.906676e-01 19 45522523 45522531 9 + 2.005 1.977 -0.095
ENSG00000125753 E018 97.3307224 1.830844e-04 3.067866e-01 6.333649e-01 19 45522532 45522534 3 + 1.983 1.950 -0.113
ENSG00000125753 E019 116.1694871 1.673924e-03 3.118677e-01 6.379396e-01 19 45522535 45522555 21 + 2.060 2.025 -0.116
ENSG00000125753 E020 140.8492977 6.296340e-04 2.313458e-01 5.571877e-01 19 45522556 45522581 26 + 2.143 2.108 -0.116
ENSG00000125753 E021 91.8023927 2.102569e-04 2.460695e-01 5.726268e-01 19 45522718 45522720 3 + 1.960 1.921 -0.132
ENSG00000125753 E022 127.9249132 1.361309e-04 6.258820e-01 8.502374e-01 19 45522721 45522733 13 + 2.094 2.080 -0.046
ENSG00000125753 E023 189.2580657 1.756305e-04 1.213438e-01 4.029686e-01 19 45522734 45522788 55 + 2.271 2.234 -0.123
ENSG00000125753 E024 219.6819348 8.864435e-05 4.422419e-01 7.423277e-01 19 45522789 45522818 30 + 2.317 2.334 0.056
ENSG00000125753 E025 301.2536530 6.348361e-05 1.856916e-01 4.995894e-01 19 45523644 45523695 52 + 2.451 2.475 0.081
ENSG00000125753 E026 1.3602217 1.386286e-02 1.249421e-01 4.096269e-01 19 45523696 45523840 145 + 0.263 0.499 1.371
ENSG00000125753 E027 189.4002215 8.571140e-05 2.611570e-01 5.888486e-01 19 45523841 45523843 3 + 2.249 2.276 0.087
ENSG00000125753 E028 275.2072958 1.112339e-04 8.977963e-02 3.439199e-01 19 45523844 45523877 34 + 2.408 2.441 0.110
ENSG00000125753 E029 5.9374736 4.368626e-02 2.695232e-01 5.975543e-01 19 45523878 45524036 159 + 0.766 0.913 0.572
ENSG00000125753 E030 5.4683611 6.876078e-02 3.709603e-03 4.722493e-02 19 45524037 45524096 60 + 0.602 1.015 1.639
ENSG00000125753 E031 319.1282820 5.498241e-04 6.650419e-01 8.698453e-01 19 45524097 45524142 46 + 2.481 2.490 0.029
ENSG00000125753 E032 4.6913758 3.217793e-02 6.238932e-01 8.494266e-01 19 45524143 45524413 271 + 0.713 0.781 0.272
ENSG00000125753 E033 469.1955339 8.148458e-05 1.685353e-01 4.753852e-01 19 45524570 45524660 91 + 2.644 2.664 0.068
ENSG00000125753 E034 5.9213960 1.653459e-02 3.366859e-01 6.596534e-01 19 45524878 45525077 200 + 0.778 0.894 0.449
ENSG00000125753 E035 3.2848042 1.175672e-01 3.351369e-01 6.581700e-01 19 45525794 45525945 152 + 0.544 0.725 0.785
ENSG00000125753 E036 427.5162154 5.552530e-05 3.660177e-03 4.673756e-02 19 45525946 45526003 58 + 2.595 2.639 0.148
ENSG00000125753 E037 1946.8121111 2.665462e-05 4.004810e-21 1.476384e-18 19 45526140 45527706 1567 + 3.247 3.307 0.200

Help

Please Click HERE to learn more details about the results from DEXseq.