ENSG00000127452

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000247977 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding protein_coding 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 2.233140 0.8304845 3.9732564 0.8304845 2.5747079 2.2446553 0.13229167 0.039400 0.224550 0.185150 9.928472e-01 1.995238e-05 FALSE TRUE
ENST00000586073 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding protein_coding 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 1.468027 1.3125467 2.0534844 0.3490924 0.8133736 0.6417639 0.07354167 0.067125 0.101625 0.034500 9.928472e-01 1.995238e-05 FALSE TRUE
ENST00000586651 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding protein_coding 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 4.960910 8.5467571 0.9177704 1.1320374 0.9177704 -3.2052244 0.25464167 0.459200 0.045050 -0.414150 9.954233e-02 1.995238e-05 FALSE TRUE
ENST00000588922 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding protein_coding 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 2.981320 0.0000000 6.1276119 0.0000000 0.8505786 9.2615336 0.15112500 0.000000 0.325000 0.325000 1.995238e-05 1.995238e-05 FALSE TRUE
ENST00000589626 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding protein_coding 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 3.076933 3.1428746 2.0576924 1.5144721 1.3072495 -0.6086462 0.15773333 0.160825 0.097075 -0.063750 9.928472e-01 1.995238e-05 FALSE TRUE
ENST00000590808 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding nonsense_mediated_decay 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 2.053132 2.6886095 1.5230702 0.9552598 0.5509953 -0.8157924 0.10138333 0.136800 0.076200 -0.060600 9.928472e-01 1.995238e-05 FALSE FALSE
ENST00000591009 ENSG00000127452 No_inf pgwt_inf FBXL12 protein_coding protein_coding 19.25247 19.1186 19.17038 1.033587 1.196897 0.003900143 1.526158 1.5762119 1.3126367 0.4873780 0.4807901 -0.2621687 0.07800000 0.083050 0.066725 -0.016325 9.932366e-01 1.995238e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000127452 E001 0.3945449 0.494647737 2.535320e-01   19 9810267 9810269 3 - 0.000 0.247 11.513
ENSG00000127452 E002 0.5256938 0.152980558 5.723147e-02   19 9810270 9810270 1 - 0.000 0.305 14.213
ENSG00000127452 E003 53.3450811 0.000289239 2.502594e-02 0.165724578 19 9810271 9810860 590 - 1.690 1.773 0.281
ENSG00000127452 E004 8.6408845 0.001721235 3.051124e-01 0.632060974 19 9810861 9810895 35 - 0.931 1.028 0.362
ENSG00000127452 E005 21.6482774 0.001982997 3.410816e-01 0.663068607 19 9810896 9811125 230 - 1.322 1.383 0.212
ENSG00000127452 E006 6.1036167 0.041137428 1.126163e-01 0.388028154 19 9811126 9811155 30 - 0.738 0.937 0.773
ENSG00000127452 E007 12.6455119 0.001290137 6.405573e-01 0.857843516 19 9811156 9811281 126 - 1.114 1.154 0.142
ENSG00000127452 E008 7.7404030 0.002069084 6.829006e-01 0.878608831 19 9811282 9811307 26 - 0.919 0.961 0.160
ENSG00000127452 E009 13.9549702 0.001066902 9.947261e-01 1.000000000 19 9811308 9811453 146 - 1.173 1.176 0.013
ENSG00000127452 E010 12.2680073 0.001143862 2.472238e-01 0.573932939 19 9811454 9811549 96 - 1.166 1.077 -0.318
ENSG00000127452 E011 19.9283652 0.001268458 7.952773e-01 0.929457481 19 9811550 9811717 168 - 1.327 1.314 -0.046
ENSG00000127452 E012 2.7544065 0.011590041 1.559919e-01 0.457159379 19 9813231 9813274 44 - 0.460 0.659 0.921
ENSG00000127452 E013 3.6831233 0.003955602 8.463408e-01 0.949334843 19 9813275 9813413 139 - 0.656 0.683 0.114
ENSG00000127452 E014 4.3519761 0.014419638 1.800876e-01 0.492557551 19 9814138 9814339 202 - 0.633 0.803 0.699
ENSG00000127452 E015 1.1128102 0.011141328 6.625702e-01 0.868471472 19 9814340 9814342 3 - 0.288 0.357 0.436
ENSG00000127452 E016 2.5512792 0.006985955 6.275017e-01 0.850776257 19 9814572 9814669 98 - 0.583 0.517 -0.301
ENSG00000127452 E017 5.2719391 0.089599022 8.845848e-01 0.963856121 19 9818154 9818544 391 - 0.791 0.803 0.047
ENSG00000127452 E018 7.7794200 0.004587084 1.020200e-02 0.093943303 19 9818545 9818617 73 - 1.055 0.803 -0.953
ENSG00000127452 E019 0.1145948 0.011256179 5.775557e-01   19 9818618 9818727 110 - 0.092 0.000 -13.465
ENSG00000127452 E020 3.8221383 0.008092247 5.647518e-02 0.265783794 19 9818728 9818753 26 - 0.791 0.550 -1.024
ENSG00000127452 E021 7.6564516 0.001875215 7.602666e-06 0.000335332 19 9818754 9818831 78 - 1.114 0.659 -1.751
ENSG00000127452 E022 5.6680379 0.002554143 2.989160e-04 0.007102537 19 9818832 9819103 272 - 0.987 0.580 -1.636
ENSG00000127452 E023 0.1308632 0.012247843 5.009409e-01   19 9827791 9827816 26 - 0.000 0.099 12.726

Help

Please Click HERE to learn more details about the results from DEXseq.