ENSG00000134333

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422447 ENSG00000134333 No_inf pgwt_inf LDHA protein_coding protein_coding 608.5745 221.236 652.666 37.17535 181.4424 1.560716 219.16222 97.396739 301.0515 0.9744619 3.649563 1.627965 0.44563333 0.500750 0.553475 0.052725 1.000000e+00 2.527185e-05 FALSE  
ENST00000541097 ENSG00000134333 No_inf pgwt_inf LDHA protein_coding nonsense_mediated_decay 608.5745 221.236 652.666 37.17535 181.4424 1.560716 18.26280 0.000000 47.2267 0.0000000 8.314020 12.205693 0.03410000 0.000000 0.095675 0.095675 2.527185e-05 2.527185e-05 FALSE  
ENST00000543445 ENSG00000134333 No_inf pgwt_inf LDHA protein_coding protein_coding 608.5745 221.236 652.666 37.17535 181.4424 1.560716 15.27198 3.581804 37.8370 3.0253066 7.128887 3.397399 0.02916667 0.014200 0.066800 0.052600 5.383816e-01 2.527185e-05 FALSE  
ENST00000625635 ENSG00000134333 No_inf pgwt_inf LDHA protein_coding protein_coding 608.5745 221.236 652.666 37.17535 181.4424 1.560716 338.62731 111.749005 246.0248 39.1149067 189.251186 1.138471 0.45312500 0.433175 0.246875 -0.186300 9.928472e-01 2.527185e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000134333 E001 0.7208635 2.299205e-01 6.620065e-01 0.8681210479 11 18394560 18394560 1 + 0.191 0.272 0.655
ENSG00000134333 E002 0.7208635 2.299205e-01 6.620065e-01 0.8681210479 11 18394561 18394561 1 + 0.191 0.272 0.655
ENSG00000134333 E003 0.7208635 2.299205e-01 6.620065e-01 0.8681210479 11 18394562 18394562 1 + 0.191 0.272 0.655
ENSG00000134333 E004 22.6244840 6.378688e-04 7.295445e-01 0.9014327759 11 18394563 18394585 23 + 1.317 1.340 0.080
ENSG00000134333 E005 62.7364494 7.755372e-04 7.141802e-01 0.8939419664 11 18394586 18394611 26 + 1.757 1.739 -0.060
ENSG00000134333 E006 80.6379633 2.767344e-04 9.278590e-01 0.9799920993 11 18394612 18394636 25 + 1.861 1.856 -0.016
ENSG00000134333 E007 0.0000000       11 18394637 18394641 5 +      
ENSG00000134333 E008 0.0000000       11 18394642 18394703 62 +      
ENSG00000134333 E009 0.1138060 1.117558e-02 1.000000e+00   11 18394704 18394886 183 + 0.056 0.000 -9.467
ENSG00000134333 E010 0.1145948 1.125879e-02 1.000000e+00   11 18395124 18395273 150 + 0.056 0.000 -9.465
ENSG00000134333 E011 0.0000000       11 18396266 18396277 12 +      
ENSG00000134333 E012 0.5078459 1.533201e-02 3.339608e-02   11 18396278 18396479 202 + 0.056 0.362 3.240
ENSG00000134333 E013 0.1138060 1.117558e-02 1.000000e+00   11 18396480 18396553 74 + 0.056 0.000 -9.467
ENSG00000134333 E014 0.1308632 1.227447e-02 1.415300e-01   11 18396554 18396610 57 + 0.000 0.157 10.625
ENSG00000134333 E015 0.0000000       11 18396611 18396817 207 +      
ENSG00000134333 E016 0.0000000       11 18396818 18396818 1 +      
ENSG00000134333 E017 106.3877743 1.644589e-04 8.483822e-01 0.9502245002 11 18396819 18396842 24 + 1.981 1.973 -0.026
ENSG00000134333 E018 217.9164981 8.022271e-05 9.010340e-01 0.9705833945 11 18396843 18396954 112 + 2.289 2.285 -0.014
ENSG00000134333 E019 103.8046788 1.450444e-04 2.113009e-01 0.5326268763 11 18396955 18396968 14 + 1.979 1.935 -0.148
ENSG00000134333 E020 1.0966861 1.174316e-02 1.863325e-01 0.5002603705 11 18396969 18397398 430 + 0.228 0.437 1.333
ENSG00000134333 E021 0.0000000       11 18398630 18398797 168 +      
ENSG00000134333 E022 0.0000000       11 18398798 18398865 68 +      
ENSG00000134333 E023 0.2450991 1.631989e-02 3.668348e-01   11 18398866 18398988 123 + 0.056 0.157 1.655
ENSG00000134333 E024 0.8345736 1.877204e-02 7.856531e-01 0.9257016459 11 18398989 18399430 442 + 0.228 0.272 0.333
ENSG00000134333 E025 205.2029959 3.851992e-04 6.369865e-02 0.2848312738 11 18399431 18399548 118 + 2.274 2.226 -0.160
ENSG00000134333 E026 2.4388251 6.033701e-03 4.350081e-02 0.2291866058 11 18399549 18399725 177 + 0.401 0.691 1.365
ENSG00000134333 E027 9.4167597 1.534409e-03 5.200129e-03 0.0597002746 11 18399726 18400629 904 + 0.882 1.147 0.977
ENSG00000134333 E028 1.8148577 7.351862e-03 1.771109e-01 0.4884190109 11 18400630 18400745 116 + 0.351 0.557 1.070
ENSG00000134333 E029 1.4042131 9.222907e-03 5.367117e-01 0.8030209626 11 18400746 18400836 91 + 0.377 0.272 -0.667
ENSG00000134333 E030 195.6612289 9.598739e-05 2.800797e-02 0.1771302197 11 18400837 18400906 70 + 2.255 2.199 -0.187
ENSG00000134333 E031 174.9793275 6.608329e-04 8.130712e-02 0.3261993543 11 18400907 18401010 104 + 2.206 2.156 -0.168
ENSG00000134333 E032 0.0000000       11 18401011 18401025 15 +      
ENSG00000134333 E033 0.7181718 3.850137e-01 6.671483e-01 0.8709052949 11 18402535 18402839 305 + 0.191 0.271 0.654
ENSG00000134333 E034 171.6384125 8.458286e-03 7.453174e-01 0.9086631183 11 18402840 18403013 174 + 2.188 2.176 -0.038
ENSG00000134333 E035 164.6197117 1.003679e-04 9.603836e-01 0.9904636673 11 18403694 18403737 44 + 2.167 2.165 -0.008
ENSG00000134333 E036 176.2320386 9.588955e-05 7.305388e-01 0.9017246384 11 18403738 18403788 51 + 2.199 2.189 -0.034
ENSG00000134333 E037 127.0453404 6.208483e-04 2.331627e-02 0.1585727803 11 18403789 18403811 23 + 2.074 1.998 -0.253
ENSG00000134333 E038 268.6633356 1.521970e-03 1.441607e-01 0.4392169915 11 18405449 18405572 124 + 2.388 2.349 -0.130
ENSG00000134333 E039 0.3763283 1.672938e-02 1.173611e-01   11 18405573 18405574 2 + 0.056 0.272 2.655
ENSG00000134333 E040 253.3983269 6.896452e-05 3.168070e-01 0.6422642883 11 18407117 18407238 122 + 2.347 2.367 0.066
ENSG00000134333 E041 1010.4291941 3.761502e-05 2.375003e-06 0.0001209975 11 18407239 18408425 1187 + 2.940 2.983 0.140

Help

Please Click HERE to learn more details about the results from DEXseq.