ENSG00000134516

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000520450 ENSG00000134516 No_inf pgwt_inf DOCK2 protein_coding retained_intron 42.83887 32.71703 47.22008 0.8392963 0.5559497 0.5292236 2.362972 3.291716 2.167546 0.3211864 0.313585 -0.600512767 0.06021667 0.101075 0.046050 -0.055025 9.469470e-01 7.568271e-05 FALSE TRUE
ENST00000520908 ENSG00000134516 No_inf pgwt_inf DOCK2 protein_coding protein_coding 42.83887 32.71703 47.22008 0.8392963 0.5559497 0.5292236 13.294618 4.875054 18.689061 1.7234291 1.477272 1.936519376 0.29245833 0.146700 0.394850 0.248150 9.403164e-01 7.568271e-05 FALSE TRUE
ENST00000523351 ENSG00000134516 No_inf pgwt_inf DOCK2 protein_coding protein_coding_CDS_not_defined 42.83887 32.71703 47.22008 0.8392963 0.5559497 0.5292236 13.624667 13.305162 18.391395 1.6327491 1.317507 0.466745155 0.32732500 0.403925 0.389250 -0.014675 1.000000e+00 7.568271e-05 FALSE TRUE
MSTRG.23895.7 ENSG00000134516 No_inf pgwt_inf DOCK2 protein_coding   42.83887 32.71703 47.22008 0.8392963 0.5559497 0.5292236 4.159941 4.316174 0.000000 1.0253658 0.000000 -8.756947805 0.10017500 0.132350 0.000000 -0.132350 7.568271e-05 7.568271e-05 FALSE TRUE
MSTRG.23895.8 ENSG00000134516 No_inf pgwt_inf DOCK2 protein_coding   42.83887 32.71703 47.22008 0.8392963 0.5559497 0.5292236 5.345157 3.189777 3.202320 2.0265250 1.848905 0.005644534 0.12295833 0.101775 0.068525 -0.033250 1.000000e+00 7.568271e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000134516 E001 0.2277562 0.0153762975 4.256940e-01   5 169637238 169637267 30 + 0.145 0.000 -9.978
ENSG00000134516 E002 0.3417064 0.0272111899 2.172239e-01   5 169637268 169637274 7 + 0.202 0.000 -13.374
ENSG00000134516 E003 0.8324175 0.2426133488 7.031630e-01 0.8887197109 5 169637275 169637285 11 + 0.298 0.206 -0.702
ENSG00000134516 E004 1.6644831 0.0969310826 5.029134e-01 0.7826080613 5 169637286 169637290 5 + 0.473 0.345 -0.703
ENSG00000134516 E005 2.9384347 0.0413308372 6.236474e-02 0.2811391522 5 169637291 169637326 36 + 0.695 0.401 -1.381
ENSG00000134516 E006 4.3945347 0.0048530953 1.176639e-01 0.3970285799 5 169637327 169637369 43 + 0.802 0.606 -0.814
ENSG00000134516 E007 6.9140732 0.0020843214 1.083404e-01 0.3799286650 5 169654403 169654486 84 + 0.959 0.789 -0.651
ENSG00000134516 E008 0.0000000       5 169654487 169654806 320 +      
ENSG00000134516 E009 6.0456935 0.0026317386 3.699930e-02 0.2091431057 5 169669288 169669328 41 + 0.930 0.694 -0.929
ENSG00000134516 E010 0.1315150 0.0123146899 3.464440e-01   5 169670167 169670189 23 + 0.000 0.115 11.854
ENSG00000134516 E011 7.7904630 0.0235955714 1.214855e-02 0.1055684743 5 169670542 169670597 56 + 1.044 0.744 -1.147
ENSG00000134516 E012 11.0085732 0.0012745661 2.838208e-03 0.0392412222 5 169671078 169671174 97 + 1.171 0.902 -0.987
ENSG00000134516 E013 17.8815342 0.0051172268 2.193285e-01 0.5426581512 5 169674297 169674445 149 + 1.309 1.217 -0.324
ENSG00000134516 E014 0.1145948 0.0112274140 8.377538e-01   5 169681730 169681743 14 + 0.078 0.000 -11.988
ENSG00000134516 E015 16.9955458 0.0008506458 8.072516e-02 0.3246592308 5 169681744 169681879 136 + 1.300 1.175 -0.443
ENSG00000134516 E016 17.4717732 0.0067092230 9.595045e-02 0.3566215359 5 169684196 169684350 155 + 1.313 1.184 -0.456
ENSG00000134516 E017 5.5899419 0.1760488642 2.783659e-01 0.6063557075 5 169689252 169689275 24 + 0.888 0.694 -0.768
ENSG00000134516 E018 7.9913801 0.0017888469 1.025323e-01 0.3688439046 5 169689276 169689333 58 + 1.012 0.849 -0.614
ENSG00000134516 E019 0.0000000       5 169695179 169695216 38 +      
ENSG00000134516 E020 0.0000000       5 169695286 169695364 79 +      
ENSG00000134516 E021 9.0512830 0.0015072487 5.653619e-02 0.2660001715 5 169695803 169695848 46 + 1.067 0.885 -0.677
ENSG00000134516 E022 14.7096713 0.0010767157 6.820195e-01 0.8782459011 5 169695849 169695938 90 + 1.205 1.175 -0.106
ENSG00000134516 E023 15.4710360 0.0059569811 2.585079e-01 0.5862320735 5 169698374 169698449 76 + 1.171 1.262 0.322
ENSG00000134516 E024 14.3259829 0.0020691640 4.559732e-01 0.7521999634 5 169699382 169699458 77 + 1.205 1.148 -0.203
ENSG00000134516 E025 18.7962938 0.0007783735 6.950709e-02 0.2989307588 5 169700014 169700139 126 + 1.341 1.217 -0.437
ENSG00000134516 E026 17.0003677 0.0022526464 6.454756e-01 0.8599917332 5 169702303 169702427 125 + 1.264 1.232 -0.113
ENSG00000134516 E027 0.1138060 0.0112285005 8.377279e-01   5 169702428 169702623 196 + 0.078 0.000 -11.988
ENSG00000134516 E028 0.0000000       5 169703949 169704075 127 +      
ENSG00000134516 E029 14.9928808 0.0016834226 9.959465e-01 1.0000000000 5 169708169 169708267 99 + 1.199 1.200 0.005
ENSG00000134516 E030 12.7606893 0.0011324528 4.004697e-02 0.2188074882 5 169711935 169712007 73 + 1.199 1.030 -0.610
ENSG00000134516 E031 17.1839341 0.0017784910 5.140510e-04 0.0107688158 5 169712120 169712223 104 + 1.349 1.087 -0.927
ENSG00000134516 E032 21.4537528 0.0096983337 1.581004e-01 0.4602391021 5 169714028 169714211 184 + 1.389 1.283 -0.369
ENSG00000134516 E033 16.8128556 0.0042412063 2.950863e-01 0.6232326497 5 169714360 169714457 98 + 1.278 1.200 -0.274
ENSG00000134516 E034 17.7664949 0.0020206783 2.145037e-01 0.5366443524 5 169716213 169716302 90 + 1.305 1.217 -0.309
ENSG00000134516 E035 18.9962480 0.0022439563 3.057757e-01 0.6326823148 5 169717384 169717484 101 + 1.325 1.255 -0.246
ENSG00000134516 E036 18.9992932 0.0033358030 3.181793e-01 0.6436473953 5 169718657 169718745 89 + 1.325 1.255 -0.246
ENSG00000134516 E037 16.1166697 0.0008392451 3.803242e-01 0.6967751013 5 169718746 169718791 46 + 1.255 1.192 -0.223
ENSG00000134516 E038 13.9810700 0.0151113528 1.334226e-01 0.4231865313 5 169747396 169747425 30 + 1.225 1.087 -0.494
ENSG00000134516 E039 20.8810056 0.0084036367 2.348324e-01 0.5599023757 5 169747426 169747504 79 + 1.371 1.283 -0.307
ENSG00000134516 E040 18.2434016 0.0067431733 9.296383e-01 0.9803718223 5 169759705 169759775 71 + 1.283 1.276 -0.022
ENSG00000134516 E041 0.2628107 0.0160857162 1.280485e-01   5 169761307 169761518 212 + 0.000 0.206 12.790
ENSG00000134516 E042 25.8151118 0.0005380443 1.481646e-02 0.1195411156 5 169761519 169761625 107 + 1.357 1.500 0.496
ENSG00000134516 E043 0.0000000       5 169779571 169780017 447 +      
ENSG00000134516 E044 25.3418679 0.0065660082 1.848228e-01 0.4983240956 5 169803058 169803206 149 + 1.375 1.466 0.312
ENSG00000134516 E045 20.5951066 0.0009236835 6.098284e-02 0.2780737982 5 169840757 169840852 96 + 1.379 1.255 -0.432
ENSG00000134516 E046 0.7707205 0.1311761215 4.773529e-02 0.2409274918 5 169841401 169841535 135 + 0.078 0.401 2.941
ENSG00000134516 E047 2.2091172 0.0099529232 3.797858e-01 0.6964182301 5 169875226 169875877 652 + 0.444 0.572 0.619
ENSG00000134516 E048 1.8147180 0.0083011282 9.711277e-01 0.9945267841 5 169934652 169934871 220 + 0.444 0.450 0.034
ENSG00000134516 E049 14.9633800 0.0009796032 7.121616e-01 0.8929522378 5 169983068 169983107 40 + 1.210 1.184 -0.093
ENSG00000134516 E050 16.8823168 0.0008350520 4.885881e-01 0.7735197273 5 169983108 169983166 59 + 1.225 1.276 0.180
ENSG00000134516 E051 19.1603714 0.0040615699 5.597511e-01 0.8159636060 5 169985828 169985922 95 + 1.317 1.276 -0.142
ENSG00000134516 E052 19.4677252 0.0085490865 3.193823e-01 0.6445714843 5 169996086 169996164 79 + 1.337 1.262 -0.263
ENSG00000134516 E053 0.0000000       5 169997974 169998024 51 +      
ENSG00000134516 E054 0.6232296 0.0227134961 3.627227e-01   5 170000031 170000471 441 + 0.145 0.281 1.204
ENSG00000134516 E055 23.4353219 0.0012282772 2.413187e-01 0.5673383914 5 170008497 170008597 101 + 1.413 1.341 -0.250
ENSG00000134516 E056 19.2521497 0.0017087881 1.796024e-01 0.4918833106 5 170008688 170008746 59 + 1.260 1.353 0.326
ENSG00000134516 E057 34.6381821 0.0019794892 7.399982e-01 0.9061320292 5 170018960 170019108 149 + 1.539 1.559 0.067
ENSG00000134516 E058 25.1168315 0.0005923428 7.529576e-01 0.9117172512 5 170027863 170027928 66 + 1.420 1.403 -0.059
ENSG00000134516 E059 17.0506575 0.0009105039 2.208674e-01 0.5446986808 5 170027929 170027948 20 + 1.287 1.200 -0.306
ENSG00000134516 E060 48.9265732 0.0006013652 3.378227e-01 0.6603902327 5 170034399 170034555 157 + 1.711 1.670 -0.137
ENSG00000134516 E061 23.5221489 0.0011024851 6.554259e-01 0.8656810990 5 170036515 170036555 41 + 1.396 1.370 -0.091
ENSG00000134516 E062 0.4914489 0.0880503137 6.883913e-01   5 170040635 170041054 420 + 0.145 0.206 0.619
ENSG00000134516 E063 27.1697669 0.0005341086 7.901968e-01 0.9274870990 5 170041055 170041145 91 + 1.451 1.438 -0.047
ENSG00000134516 E064 33.8806671 0.0003897590 8.746691e-01 0.9604553992 5 170042013 170042132 120 + 1.534 1.544 0.034
ENSG00000134516 E065 30.1111200 0.0011159327 9.541411e-01 0.9887277265 5 170045816 170045905 90 + 1.489 1.488 -0.005
ENSG00000134516 E066 33.5648698 0.0069784242 7.107646e-01 0.8926212908 5 170047510 170047614 105 + 1.524 1.548 0.081
ENSG00000134516 E067 49.8694173 0.0006770752 6.706498e-01 0.8726816835 5 170050256 170050397 142 + 1.709 1.692 -0.057
ENSG00000134516 E068 41.3857571 0.0003477901 3.114160e-01 0.6375498530 5 170055305 170055386 82 + 1.601 1.650 0.167
ENSG00000134516 E069 6.2834781 0.0024323284 5.658446e-02 0.2660731226 5 170055387 170056683 1297 + 0.759 0.963 0.789
ENSG00000134516 E070 42.3184029 0.0003717091 4.595859e-01 0.7541000548 5 170056684 170056768 85 + 1.646 1.613 -0.112
ENSG00000134516 E071 17.5855080 0.0161657136 1.945149e-05 0.0007526251 5 170056769 170057579 811 + 1.067 1.438 1.307
ENSG00000134516 E072 40.9537072 0.0012274479 6.409539e-01 0.8578508680 5 170057580 170057666 87 + 1.608 1.632 0.083
ENSG00000134516 E073 68.9044838 0.0002143139 6.033572e-01 0.8390040360 5 170067510 170067686 177 + 1.831 1.852 0.070
ENSG00000134516 E074 32.6732661 0.0014629905 8.825710e-01 0.9631444870 5 170069137 170069220 84 + 1.519 1.528 0.034
ENSG00000134516 E075 1.7175177 0.1474961388 4.531671e-01 0.7500235470 5 170075444 170075946 503 + 0.377 0.495 0.619
ENSG00000134516 E076 46.4109663 0.0004847676 4.538690e-02 0.2341505229 5 170075947 170076084 138 + 1.630 1.721 0.307
ENSG00000134516 E077 51.1746464 0.0030186810 1.700666e-01 0.4776296586 5 170077710 170077837 128 + 1.683 1.750 0.226
ENSG00000134516 E078 88.6237857 0.0077336493 1.350543e-01 0.4259695798 5 170078975 170079146 172 + 1.916 1.988 0.241
ENSG00000134516 E079 2.9004357 0.0069397639 4.252323e-03 0.0520015765 5 170079147 170080162 1016 + 0.377 0.767 1.811
ENSG00000134516 E080 70.2900031 0.0020779211 4.540005e-01 0.7505754249 5 170080163 170080283 121 + 1.835 1.866 0.106
ENSG00000134516 E081 4.5652684 0.0032927893 7.869108e-02 0.3200823510 5 170080284 170081841 1558 + 0.639 0.849 0.853
ENSG00000134516 E082 48.1779764 0.0064328786 4.012964e-01 0.7124505164 5 170081842 170081928 87 + 1.667 1.713 0.157
ENSG00000134516 E083 38.4150639 0.0036404047 8.643961e-01 0.9566984198 5 170081929 170081984 56 + 1.595 1.587 -0.027
ENSG00000134516 E084 170.3900975 0.0001086522 2.776739e-04 0.0066911475 5 170082796 170083382 587 + 2.192 2.275 0.279

Help

Please Click HERE to learn more details about the results from DEXseq.