ENSG00000135540

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343505 ENSG00000135540 No_inf pgwt_inf NHSL1 protein_coding protein_coding 3.429349 3.021494 3.335941 0.2403953 0.1623857 0.1423828 2.26046015 1.3534008 3.152754 0.09833215 0.20435029 1.213971 0.66129167 0.454925 0.94310 0.488175 0.03351479 0.03351479 FALSE TRUE
ENST00000427025 ENSG00000135540 No_inf pgwt_inf NHSL1 protein_coding protein_coding 3.429349 3.021494 3.335941 0.2403953 0.1623857 0.1423828 0.19613733 0.3096028 0.111500 0.15456405 0.06461815 -1.395324 0.05982500 0.105025 0.03285 -0.072175 0.99284725 0.03351479 FALSE TRUE
ENST00000468095 ENSG00000135540 No_inf pgwt_inf NHSL1 protein_coding retained_intron 3.429349 3.021494 3.335941 0.2403953 0.1623857 0.1423828 0.06374194 0.1912258 0.000000 0.19122582 0.00000000 -4.330744 0.02750833 0.082525 0.00000 -0.082525 0.99284725 0.03351479   FALSE
ENST00000491526 ENSG00000135540 No_inf pgwt_inf NHSL1 protein_coding protein_coding 3.429349 3.021494 3.335941 0.2403953 0.1623857 0.1423828 0.85825175 1.1672648 0.000000 0.41121811 0.00000000 -6.879295 0.23703333 0.357475 0.00000 -0.357475 0.24561520 0.03351479 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000135540 E001 50.2617731 0.0003499278 0.005831648 0.06456285 6 138422043 138424816 2774 - 1.664 1.746 0.276
ENSG00000135540 E002 3.8229112 0.0040429626 0.697241073 0.88490340 6 138429711 138429843 133 - 0.691 0.641 -0.212
ENSG00000135540 E003 35.6253113 0.0005043388 0.014433958 0.11769187 6 138430393 138433507 3115 - 1.587 1.482 -0.360
ENSG00000135540 E004 2.1583569 0.0070135201 0.922009793 0.97792404 6 138433508 138433680 173 - 0.496 0.481 -0.075
ENSG00000135540 E005 0.5867447 0.0159031161 0.499132614   6 138441983 138442114 132 - 0.233 0.126 -1.075
ENSG00000135540 E006 0.2281253 0.0157317420 0.559131542   6 138446790 138447000 211 - 0.132 0.000 -11.375
ENSG00000135540 E007 1.4555812 0.0149946714 0.614003879 0.84456159 6 138447001 138447064 64 - 0.351 0.429 0.440
ENSG00000135540 E008 0.4737248 0.0157739299 0.721983579   6 138447065 138447123 59 - 0.186 0.126 -0.660
ENSG00000135540 E009 0.2461098 0.0163784493 0.614414463   6 138447124 138447193 70 - 0.071 0.126 0.925
ENSG00000135540 E010 0.0000000       6 138470541 138470594 54 -      
ENSG00000135540 E011 0.5880411 0.0146550474 0.498087626   6 138473306 138473433 128 - 0.233 0.126 -1.075
ENSG00000135540 E012 0.8322635 0.0145703849 0.743081493 0.90743693 6 138496219 138496371 153 - 0.276 0.224 -0.397
ENSG00000135540 E013 0.0000000       6 138499233 138499494 262 -      
ENSG00000135540 E014 0.0000000       6 138512279 138512495 217 -      
ENSG00000135540 E015 0.0000000       6 138545623 138545711 89 -      
ENSG00000135540 E016 0.1141751 0.0116804403 1.000000000   6 138571530 138571698 169 - 0.071 0.000 -10.443
ENSG00000135540 E017 0.0000000       6 138571699 138571709 11 -      
ENSG00000135540 E018 0.0000000       6 138571710 138572061 352 -      
ENSG00000135540 E019 0.0000000       6 138572062 138572385 324 -      
ENSG00000135540 E020 0.0000000       6 138572386 138572540 155 -      
ENSG00000135540 E021 0.1311489 0.0123119629 0.269523905   6 138692476 138692591 116 - 0.000 0.126 10.883

Help

Please Click HERE to learn more details about the results from DEXseq.