ENSG00000137504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000490820 ENSG00000137504 No_inf pgwt_inf CREBZF protein_coding nonsense_mediated_decay 19.4897 25.92397 16.77937 0.6285208 0.3012536 -0.6272946 7.869125 13.53571656 5.333158 0.34421870 0.6309687 -1.3420720 0.381450 0.522525 0.319825 -0.202700 0.9193577902 0.0004747468 TRUE TRUE
ENST00000527447 ENSG00000137504 No_inf pgwt_inf CREBZF protein_coding protein_coding 19.4897 25.92397 16.77937 0.6285208 0.3012536 -0.6272946 7.814375 9.75964641 6.684775 0.14238874 0.2268707 -0.5452708 0.406725 0.376900 0.398425 0.021525 1.0000000000 0.0004747468 FALSE TRUE
ENST00000528889 ENSG00000137504 No_inf pgwt_inf CREBZF protein_coding retained_intron 19.4897 25.92397 16.77937 0.6285208 0.3012536 -0.6272946 2.300633 0.09400457 3.940678 0.09400457 0.9285961 5.2473815 0.138250 0.003550 0.232375 0.228825 0.0004747468 0.0004747468 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000137504 E001 0.1308632 0.0121196941 1.000000e+00   11 85657726 85657741 16 - 0.000 0.073 8.638
ENSG00000137504 E002 0.5078361 0.0185944442 6.667135e-01   11 85657742 85657977 236 - 0.122 0.191 0.767
ENSG00000137504 E003 0.1316618 0.0121800454 1.000000e+00   11 85657978 85657989 12 - 0.000 0.073 10.842
ENSG00000137504 E004 43.0955776 0.0003268971 1.120367e-04 0.0032376603 11 85657990 85659707 1718 - 1.481 1.673 0.656
ENSG00000137504 E005 56.5905139 0.0003111295 4.686007e-05 0.0015814456 11 85659708 85660148 441 - 1.609 1.785 0.596
ENSG00000137504 E006 10.5944125 0.0240514288 3.185944e-01 0.6440802587 11 85660149 85660152 4 - 0.960 1.075 0.421
ENSG00000137504 E007 12.4346063 0.0032393677 2.825991e-02 0.1780305195 11 85660153 85660167 15 - 0.960 1.160 0.728
ENSG00000137504 E008 18.7239537 0.0152934487 6.852697e-02 0.2966109287 11 85660168 85660251 84 - 1.156 1.317 0.566
ENSG00000137504 E009 14.8104570 0.0026000275 4.805253e-02 0.2418905208 11 85660252 85660334 83 - 1.057 1.222 0.592
ENSG00000137504 E010 34.1632660 0.0016155557 1.133321e-04 0.0032615857 11 85660335 85660597 263 - 1.358 1.583 0.774
ENSG00000137504 E011 111.5345709 0.0001552923 1.162635e-02 0.1024222485 11 85660598 85661636 1039 - 1.974 2.048 0.246
ENSG00000137504 E012 18.6036721 0.0152523094 7.399761e-01 0.9061320292 11 85661637 85661749 113 - 1.283 1.259 -0.086
ENSG00000137504 E013 27.5161875 0.0005592981 9.425191e-01 0.9854368081 11 85661750 85661952 203 - 1.431 1.428 -0.010
ENSG00000137504 E014 69.4298367 0.0002278924 1.794561e-01 0.4918656340 11 85661953 85662388 436 - 1.853 1.805 -0.159
ENSG00000137504 E015 23.9304852 0.0091987875 4.612927e-01 0.7550856378 11 85662389 85662457 69 - 1.404 1.354 -0.176
ENSG00000137504 E016 62.5052832 0.0003052649 2.843417e-04 0.0068239442 11 85662458 85663178 721 - 1.862 1.727 -0.456
ENSG00000137504 E017 15.3241847 0.0009720730 3.973199e-02 0.2177765624 11 85663179 85663293 115 - 1.283 1.132 -0.538
ENSG00000137504 E018 22.0603643 0.0008819065 3.169902e-03 0.0422573392 11 85663294 85663523 230 - 1.452 1.268 -0.640
ENSG00000137504 E019 20.8483696 0.0006417504 4.171077e-01 0.7239284300 11 85663524 85663601 78 - 1.276 1.332 0.195
ENSG00000137504 E020 18.2592847 0.0123391298 9.574151e-01 0.9894624118 11 85663602 85663697 96 - 1.261 1.259 -0.007
ENSG00000137504 E021 23.2507468 0.0006370234 7.041710e-04 0.0137180272 11 85663698 85663814 117 - 1.485 1.280 -0.711
ENSG00000137504 E022 131.6010877 0.0001381501 5.864829e-06 0.0002658756 11 85663815 85665129 1315 - 2.167 2.056 -0.371
ENSG00000137504 E023 0.0000000       11 85682717 85682856 140 -      
ENSG00000137504 E024 0.0000000       11 85682857 85682908 52 -      

Help

Please Click HERE to learn more details about the results from DEXseq.