ENSG00000145191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465218 ENSG00000145191 No_inf pgwt_inf EIF2B5 protein_coding retained_intron 27.13138 25.32421 28.34648 2.111872 2.000847 0.1625914 1.8715525 1.699815 2.376295 1.6998146 0.1913175 0.4809326 0.06597500 0.054525 0.085050 0.030525 0.69869597 0.02771619 TRUE  
ENST00000468748 ENSG00000145191 No_inf pgwt_inf EIF2B5 protein_coding retained_intron 27.13138 25.32421 28.34648 2.111872 2.000847 0.1625914 1.4549964 2.120998 1.103886 0.8987559 0.3745568 -0.9359279 0.05437500 0.088950 0.037300 -0.051650 0.99284725 0.02771619 TRUE  
ENST00000493740 ENSG00000145191 No_inf pgwt_inf EIF2B5 protein_coding retained_intron 27.13138 25.32421 28.34648 2.111872 2.000847 0.1625914 2.5984534 4.136038 2.144383 1.0608578 1.4642111 -0.9444588 0.09170833 0.159050 0.067425 -0.091625 0.96951912 0.02771619 FALSE  
ENST00000647636 ENSG00000145191 No_inf pgwt_inf EIF2B5 protein_coding nonsense_mediated_decay 27.13138 25.32421 28.34648 2.111872 2.000847 0.1625914 0.6301572 1.890471 0.000000 0.8101000 0.0000000 -7.5702135 0.02304167 0.069125 0.000000 -0.069125 0.02771619 0.02771619 FALSE  
ENST00000648915 ENSG00000145191 No_inf pgwt_inf EIF2B5 protein_coding protein_coding 27.13138 25.32421 28.34648 2.111872 2.000847 0.1625914 14.5027819 6.808999 17.677376 2.3209962 0.9504750 1.3750882 0.53821667 0.294725 0.628975 0.334250 0.97165384 0.02771619 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000145191 E001 0.1315150 0.0123561979 0.4217588290   3 184135038 184135193 156 + 0.000 0.106 9.665
ENSG00000145191 E002 0.0000000       3 184135194 184135336 143 +      
ENSG00000145191 E003 0.0000000       3 184135337 184135354 18 +      
ENSG00000145191 E004 0.0000000       3 184135355 184135357 3 +      
ENSG00000145191 E005 0.1145948 0.0112769906 0.6829123557   3 184135358 184135362 5 + 0.085 0.000 -12.588
ENSG00000145191 E006 0.1145948 0.0112769906 0.6829123557   3 184135363 184135364 2 + 0.085 0.000 -12.588
ENSG00000145191 E007 0.1145948 0.0112769906 0.6829123557   3 184135365 184135365 1 + 0.085 0.000 -12.588
ENSG00000145191 E008 0.4569458 0.0161958183 0.0771414724   3 184135366 184135374 9 + 0.271 0.000 -14.417
ENSG00000145191 E009 0.6847020 0.0144483155 0.0201668103 0.14483447 3 184135375 184135375 1 + 0.361 0.000 -14.923
ENSG00000145191 E010 0.9131028 0.0188587371 0.0058543444 0.06471964 3 184135376 184135376 1 + 0.436 0.000 -15.261
ENSG00000145191 E011 1.1593594 0.0429106434 0.0241617221 0.16196288 3 184135377 184135378 2 + 0.469 0.106 -2.813
ENSG00000145191 E012 2.1247452 0.0138486937 0.0595184137 0.27422046 3 184135379 184135384 6 + 0.605 0.324 -1.450
ENSG00000145191 E013 2.8445261 0.0166875617 0.0638741205 0.28503880 3 184135385 184135388 4 + 0.690 0.425 -1.228
ENSG00000145191 E014 3.5281637 0.0041090220 0.0061656807 0.06722352 3 184135389 184135391 3 + 0.792 0.425 -1.643
ENSG00000145191 E015 3.7742735 0.0047563434 0.0097444431 0.09120125 3 184135392 184135399 8 + 0.807 0.468 -1.479
ENSG00000145191 E016 4.0362856 0.0036574322 0.0363635328 0.20710165 3 184135400 184135402 3 + 0.807 0.543 -1.117
ENSG00000145191 E017 5.8686304 0.0023548498 0.1070428922 0.37796702 3 184135403 184135436 34 + 0.911 0.735 -0.687
ENSG00000145191 E018 11.1477003 0.0012498928 0.0364181167 0.20721245 3 184135437 184135493 57 + 1.159 0.982 -0.643
ENSG00000145191 E019 9.1118638 0.0015878896 0.8119248255 0.93604387 3 184135494 184135518 25 + 1.013 0.994 -0.069
ENSG00000145191 E020 7.6552057 0.0018607558 0.8517148011 0.95152735 3 184135519 184135520 2 + 0.944 0.928 -0.058
ENSG00000145191 E021 14.6617860 0.0015697551 0.0511247618 0.25101319 3 184135521 184135580 60 + 1.257 1.111 -0.520
ENSG00000145191 E022 0.4903592 0.0159140521 0.8112935766   3 184135581 184135663 83 + 0.156 0.191 0.357
ENSG00000145191 E023 0.3761841 0.0166942533 0.4452309828   3 184135664 184135748 85 + 0.085 0.191 1.357
ENSG00000145191 E024 0.1308632 0.0123377798 0.4217407084   3 184135749 184135900 152 + 0.000 0.106 12.375
ENSG00000145191 E025 0.1308632 0.0123377798 0.4217407084   3 184135901 184135916 16 + 0.000 0.106 12.375
ENSG00000145191 E026 0.0000000       3 184135917 184135951 35 +      
ENSG00000145191 E027 13.7741544 0.0011804933 0.0167993854 0.12966155 3 184136612 184136648 37 + 1.247 1.062 -0.662
ENSG00000145191 E028 13.1503619 0.0035987287 0.0114041627 0.10115782 3 184136649 184136666 18 + 1.236 1.029 -0.742
ENSG00000145191 E029 10.7027476 0.0031398767 0.1307324036 0.41951643 3 184136667 184136675 9 + 1.125 0.994 -0.476
ENSG00000145191 E030 8.7756757 0.0015919382 0.1466800777 0.44285461 3 184136676 184136678 3 + 1.048 0.914 -0.497
ENSG00000145191 E031 9.3805011 0.0014577619 0.1469966842 0.44337895 3 184136679 184136682 4 + 1.072 0.942 -0.479
ENSG00000145191 E032 9.0192961 0.0016174016 0.1609501762 0.46395531 3 184136683 184136684 2 + 1.056 0.928 -0.473
ENSG00000145191 E033 13.2365380 0.0011231958 0.1044702425 0.37253357 3 184136685 184136736 52 + 1.208 1.082 -0.450
ENSG00000145191 E034 7.3847964 0.0128150955 0.0036868933 0.04699132 3 184136737 184137431 695 + 0.744 1.062 1.213
ENSG00000145191 E035 1.6996236 0.0325561305 0.9369198583 0.98283938 3 184137432 184137530 99 + 0.436 0.425 -0.058
ENSG00000145191 E036 2.0592993 0.0069766113 0.8149822043 0.93682468 3 184137531 184137619 89 + 0.500 0.468 -0.158
ENSG00000145191 E037 28.4222450 0.0005295878 0.6890334189 0.88131907 3 184137620 184137805 186 + 1.477 1.458 -0.065
ENSG00000145191 E038 1.1479987 0.0108481629 0.0408831829 0.22141651 3 184137806 184137873 68 + 0.156 0.468 2.164
ENSG00000145191 E039 0.6230956 0.0144348630 0.4780038092   3 184137874 184137897 24 + 0.156 0.263 0.942
ENSG00000145191 E040 29.3720486 0.0005116096 0.5524240030 0.81222942 3 184137898 184138075 178 + 1.495 1.466 -0.100
ENSG00000145191 E041 0.7533750 0.0281229226 0.2742028840 0.60225205 3 184138144 184138165 22 + 0.156 0.324 1.357
ENSG00000145191 E042 18.8886320 0.0068687805 0.8068721725 0.93396747 3 184138166 184138246 81 + 1.288 1.310 0.077
ENSG00000145191 E043 1.1132423 0.1506284036 0.5453991905 0.80822548 3 184138847 184138939 93 + 0.271 0.378 0.680
ENSG00000145191 E044 0.2620121 0.0160494781 0.1706955541   3 184140057 184140079 23 + 0.000 0.191 13.308
ENSG00000145191 E045 20.3034742 0.0075532740 0.4097841241 0.71864857 3 184140080 184140148 69 + 1.297 1.360 0.218
ENSG00000145191 E046 10.6652927 0.0141247984 0.5929364206 0.83401666 3 184140149 184140157 9 + 1.088 1.040 -0.173
ENSG00000145191 E047 1.5872458 0.0082396723 0.8797087999 0.96193914 3 184140158 184140221 64 + 0.400 0.425 0.135
ENSG00000145191 E048 2.8818703 0.0049701151 0.0434616602 0.22906134 3 184140222 184140417 196 + 0.436 0.712 1.264
ENSG00000145191 E049 36.0394473 0.0004030896 0.3384366210 0.66090375 3 184140418 184140615 198 + 1.544 1.594 0.171
ENSG00000145191 E050 23.6318451 0.0006003237 0.8183754521 0.93780267 3 184140616 184140730 115 + 1.383 1.400 0.059
ENSG00000145191 E051 0.7188262 0.0140251208 0.5967889898 0.83587447 3 184140731 184140740 10 + 0.271 0.191 -0.643
ENSG00000145191 E052 3.6386244 0.0674724640 0.0585826031 0.27172551 3 184140741 184140908 168 + 0.500 0.797 1.283
ENSG00000145191 E053 1.9176957 0.0074357866 0.0047792531 0.05638032 3 184141867 184141920 54 + 0.217 0.636 2.357
ENSG00000145191 E054 1.0501505 0.0129904441 0.0007357895 0.01420885 3 184141921 184141924 4 + 0.000 0.507 15.112
ENSG00000145191 E055 30.8968131 0.0004598482 0.9148686550 0.97478150 3 184141925 184142070 146 + 1.504 1.502 -0.008
ENSG00000145191 E056 0.0000000       3 184142108 184142236 129 +      
ENSG00000145191 E057 21.1023737 0.0006706628 0.6661221537 0.87044334 3 184142237 184142297 61 + 1.329 1.360 0.106
ENSG00000145191 E058 24.1450789 0.0006055348 0.6862098295 0.88034689 3 184142298 184142378 81 + 1.387 1.414 0.094
ENSG00000145191 E059 0.5082151 0.0154743929 0.2171259294   3 184142379 184142394 16 + 0.085 0.263 1.942
ENSG00000145191 E060 32.7037965 0.0033218378 0.5669388897 0.81941081 3 184142502 184142603 102 + 1.510 1.545 0.120
ENSG00000145191 E061 46.5912237 0.0003309153 0.1661376404 0.47213788 3 184142779 184142886 108 + 1.646 1.709 0.213
ENSG00000145191 E062 41.7290787 0.0004507856 0.4127825781 0.72075045 3 184143052 184143142 91 + 1.646 1.612 -0.117
ENSG00000145191 E063 15.2345410 0.0059394871 0.0079070880 0.07951424 3 184143143 184143430 288 + 1.096 1.310 0.758
ENSG00000145191 E064 3.4509045 0.0916588980 0.4304159897 0.73357920 3 184143431 184143441 11 + 0.581 0.712 0.563
ENSG00000145191 E065 53.2719962 0.0010638315 0.0281532935 0.17775188 3 184143442 184143565 124 + 1.774 1.685 -0.302
ENSG00000145191 E066 19.6245549 0.0284605692 0.0008532267 0.01589277 3 184143566 184144078 513 + 1.132 1.454 1.128
ENSG00000145191 E067 2.9800646 0.0048952060 0.1650974416 0.47055194 3 184144079 184144098 20 + 0.500 0.688 0.842
ENSG00000145191 E068 24.6719723 0.0005673496 0.0205888710 0.14677610 3 184144099 184144127 29 + 1.467 1.333 -0.467
ENSG00000145191 E069 35.7401349 0.0003944783 0.5552111616 0.81379829 3 184144128 184144224 97 + 1.549 1.581 0.110
ENSG00000145191 E070 0.0000000       3 184144225 184144596 372 +      
ENSG00000145191 E071 33.1052103 0.0005866047 0.0642326310 0.28601354 3 184144597 184144707 111 + 1.483 1.581 0.336
ENSG00000145191 E072 1.1473536 0.0640783576 0.0522902029 0.25457426 3 184144708 184144883 176 + 0.156 0.468 2.165
ENSG00000145191 E073 57.5552919 0.0003186448 0.0070241955 0.07362023 3 184144884 184146127 1244 + 1.713 1.820 0.363

Help

Please Click HERE to learn more details about the results from DEXseq.