ENSG00000157193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000529670 ENSG00000157193 No_inf pgwt_inf LRP8 protein_coding nonsense_mediated_decay 39.7826 18.47578 54.68756 0.6303973 1.176752 1.565061 10.8325097 3.973537 15.268714 0.5894969 0.3924516 1.9394013 0.25808333 0.21260 0.279625 0.067025 9.928472e-01 3.325998e-05 TRUE TRUE
ENST00000653217 ENSG00000157193 No_inf pgwt_inf LRP8 protein_coding protein_coding 39.7826 18.47578 54.68756 0.6303973 1.176752 1.565061 5.3453752 2.705218 8.523543 0.3928187 1.7888641 1.6520769 0.13683333 0.14600 0.156175 0.010175 1.000000e+00 3.325998e-05 FALSE TRUE
ENST00000657047 ENSG00000157193 No_inf pgwt_inf LRP8 protein_coding nonsense_mediated_decay 39.7826 18.47578 54.68756 0.6303973 1.176752 1.565061 0.8775653 1.260439 0.621250 0.2967748 0.3026077 -1.0090432 0.03236667 0.06885 0.011575 -0.057275 4.597707e-01 3.325998e-05 TRUE TRUE
ENST00000668071 ENSG00000157193 No_inf pgwt_inf LRP8 protein_coding protein_coding 39.7826 18.47578 54.68756 0.6303973 1.176752 1.565061 6.3756736 0.000000 11.677726 0.0000000 0.3691278 10.1907786 0.12689167 0.00000 0.213825 0.213825 3.325998e-05 3.325998e-05 FALSE TRUE
MSTRG.1053.2 ENSG00000157193 No_inf pgwt_inf LRP8 protein_coding   39.7826 18.47578 54.68756 0.6303973 1.176752 1.565061 7.5675114 6.315494 8.289955 0.4711399 0.6567279 0.3919253 0.22390833 0.34480 0.151100 -0.193700 6.012218e-01 3.325998e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000157193 E001 0.0000000       1 53242364 53242385 22 -      
ENSG00000157193 E002 0.0000000       1 53242386 53242404 19 -      
ENSG00000157193 E003 0.0000000       1 53242405 53242405 1 -      
ENSG00000157193 E004 116.3319732 0.0043058419 4.436300e-16 1.042059e-13 1 53242406 53245541 3136 - 1.920 2.218 0.999
ENSG00000157193 E005 1.4546917 0.0226899970 3.710527e-01 6.892056e-01 1 53245542 53245544 3 - 0.320 0.466 0.820
ENSG00000157193 E006 1.5686419 0.0130703603 4.818898e-01 7.691398e-01 1 53245545 53245545 1 - 0.351 0.466 0.627
ENSG00000157193 E007 1.6828170 0.0082881764 6.032832e-01 8.389672e-01 1 53245546 53245546 1 - 0.380 0.466 0.458
ENSG00000157193 E008 5.0606768 0.0065491130 2.290820e-01 5.543275e-01 1 53245547 53245551 5 - 0.799 0.650 -0.612
ENSG00000157193 E009 7.9056946 0.0450782858 5.613450e-01 8.168416e-01 1 53245552 53245579 28 - 0.895 0.976 0.306
ENSG00000157193 E010 8.5565904 0.0450508864 8.497477e-01 9.507990e-01 1 53245580 53245590 11 - 0.959 0.939 -0.073
ENSG00000157193 E011 11.2179713 0.0014588401 1.881259e-01 5.024418e-01 1 53245591 53245623 33 - 1.092 0.976 -0.425
ENSG00000157193 E012 19.0668103 0.0014568560 1.882204e-02 1.389110e-01 1 53245624 53245681 58 - 1.321 1.149 -0.607
ENSG00000157193 E013 26.1815581 0.0013611277 2.056763e-01 5.254350e-01 1 53245682 53245981 300 - 1.426 1.353 -0.253
ENSG00000157193 E014 8.8947238 0.0015468652 2.737039e-01 6.019990e-01 1 53245982 53246551 570 - 0.928 1.042 0.421
ENSG00000157193 E015 7.9752165 0.0017352751 8.793254e-01 9.618766e-01 1 53246552 53246552 1 - 0.928 0.920 -0.031
ENSG00000157193 E016 12.4899010 0.0010865580 2.346409e-01 5.598043e-01 1 53246553 53246557 5 - 1.064 1.172 0.388
ENSG00000157193 E017 13.8486821 0.0010010403 9.254005e-02 3.493267e-01 1 53246558 53246567 10 - 1.092 1.235 0.508
ENSG00000157193 E018 14.5634638 0.0009427784 9.120552e-02 3.468318e-01 1 53246568 53246578 11 - 1.114 1.254 0.498
ENSG00000157193 E019 15.5273485 0.0010262225 7.865885e-02 3.200003e-01 1 53246579 53246594 16 - 1.139 1.281 0.503
ENSG00000157193 E020 28.4743951 0.0081985163 9.955362e-01 1.000000e+00 1 53246595 53246709 115 - 1.436 1.446 0.034
ENSG00000157193 E021 46.5068444 0.0091196792 8.903146e-02 3.424257e-01 1 53246710 53246917 208 - 1.674 1.579 -0.324
ENSG00000157193 E022 15.3828483 0.0017187221 8.710678e-03 8.475008e-02 1 53246918 53246923 6 - 1.243 1.026 -0.778
ENSG00000157193 E023 18.6052892 0.0035322369 2.257336e-02 1.556619e-01 1 53246924 53246955 32 - 1.311 1.137 -0.616
ENSG00000157193 E024 22.2771997 0.0007654473 9.222237e-01 9.779698e-01 1 53246956 53247017 62 - 1.337 1.338 0.005
ENSG00000157193 E025 19.1220211 0.0007312388 5.717683e-01 8.227298e-01 1 53247018 53247056 39 - 1.258 1.306 0.168
ENSG00000157193 E026 1.9646361 0.0163727508 8.941393e-02 3.432373e-01 1 53248463 53248591 129 - 0.351 0.611 1.306
ENSG00000157193 E027 8.4051324 0.0117796034 3.919476e-01 7.055588e-01 1 53249380 53249440 61 - 0.912 1.010 0.367
ENSG00000157193 E028 6.2936933 0.0719901562 7.984394e-01 9.307505e-01 1 53249441 53249495 55 - 0.850 0.805 -0.173
ENSG00000157193 E029 5.7542254 0.0026086215 5.380445e-01 8.037954e-01 1 53249496 53249556 61 - 0.777 0.855 0.306
ENSG00000157193 E030 31.6817806 0.0008549211 2.808267e-01 6.089283e-01 1 53250690 53250764 75 - 1.501 1.446 -0.187
ENSG00000157193 E031 30.5731343 0.0004784981 6.719090e-01 8.732433e-01 1 53250765 53250862 98 - 1.474 1.458 -0.056
ENSG00000157193 E032 9.7681808 0.0014118944 9.903843e-01 1.000000e+00 1 53251676 53252537 862 - 1.001 1.010 0.033
ENSG00000157193 E033 0.2449549 0.0163256478 4.886853e-01   1 53254911 53254957 47 - 0.063 0.141 1.306
ENSG00000157193 E034 11.2839477 0.0017561211 9.890417e-03 9.196754e-02 1 53255117 53255124 8 - 0.974 1.204 0.836
ENSG00000157193 E035 19.8253826 0.0083386324 1.476214e-01 4.443638e-01 1 53255125 53255185 61 - 1.247 1.368 0.422
ENSG00000157193 E036 1.8819201 0.0101286921 3.214397e-03 4.268121e-02 1 53255186 53257239 2054 - 0.250 0.686 2.306
ENSG00000157193 E037 37.6910938 0.0004408744 2.131976e-02 1.498055e-01 1 53257240 53257464 225 - 1.591 1.475 -0.396
ENSG00000157193 E038 0.3594960 0.0166067527 8.582659e-01   1 53258009 53258074 66 - 0.118 0.141 0.306
ENSG00000157193 E039 24.4888929 0.0005475673 6.252192e-01 8.500320e-01 1 53258319 53258465 147 - 1.384 1.361 -0.081
ENSG00000157193 E040 7.8435294 0.0018865301 7.297539e-01 9.014328e-01 1 53258466 53258471 6 - 0.928 0.899 -0.109
ENSG00000157193 E041 25.4430410 0.0097496438 2.277717e-02 1.565834e-01 1 53260464 53260605 142 - 1.439 1.272 -0.580
ENSG00000157193 E042 0.6210614 0.2542327017 2.101206e-01   1 53261213 53261787 575 - 0.118 0.333 1.890
ENSG00000157193 E043 29.6572124 0.0126919223 9.707667e-01 9.945110e-01 1 53262068 53262207 140 - 1.456 1.458 0.008
ENSG00000157193 E044 27.0982059 0.0182461678 2.429972e-01 5.692237e-01 1 53262446 53262564 119 - 1.446 1.353 -0.322
ENSG00000157193 E045 11.4782865 0.0046946754 6.719167e-01 8.732433e-01 1 53264169 53264215 47 - 1.052 1.099 0.168
ENSG00000157193 E046 28.2672898 0.0005408136 4.271208e-01 7.310647e-01 1 53264216 53264396 181 - 1.449 1.409 -0.137
ENSG00000157193 E047 25.1655001 0.0016582646 6.506699e-02 2.880375e-01 1 53266473 53266647 175 - 1.421 1.306 -0.399
ENSG00000157193 E048 0.8318438 0.0311298423 9.718438e-01 9.947504e-01 1 53266648 53266699 52 - 0.250 0.248 -0.016
ENSG00000157193 E049 1.3399624 0.2065983635 2.759666e-01 6.041969e-01 1 53266700 53268598 1899 - 0.286 0.466 1.043
ENSG00000157193 E050 23.1595608 0.0275958544 2.080339e-01 5.285520e-01 1 53271028 53271153 126 - 1.387 1.272 -0.400
ENSG00000157193 E051 20.2790694 0.0044283548 1.207488e-03 2.069767e-02 1 53271227 53271346 120 - 1.364 1.112 -0.890
ENSG00000157193 E052 0.7535391 0.0140870757 6.040749e-02 2.765191e-01 1 53271347 53271415 69 - 0.118 0.405 2.306
ENSG00000157193 E053 5.5423658 0.0025721871 2.624910e-01 5.904240e-01 1 53271416 53272603 1188 - 0.742 0.878 0.535
ENSG00000157193 E054 1.1757995 0.0105802940 5.104966e-01 7.868913e-01 1 53272604 53272642 39 - 0.351 0.248 -0.694
ENSG00000157193 E055 9.0074753 0.0023555241 3.132210e-01 6.391317e-01 1 53272643 53275630 2988 - 0.936 1.042 0.391
ENSG00000157193 E056 9.2868829 0.0434329905 1.580017e-01 4.600747e-01 1 53275631 53275654 24 - 1.034 0.855 -0.671
ENSG00000157193 E057 12.5857663 0.0874959318 1.874656e-01 5.019666e-01 1 53275655 53275753 99 - 1.153 0.976 -0.644
ENSG00000157193 E058 15.4824806 0.0009996771 1.562527e-01 4.575700e-01 1 53276692 53277078 387 - 1.219 1.112 -0.384
ENSG00000157193 E059 10.3275724 0.0193229064 3.185791e-04 7.424095e-03 1 53280587 53280715 129 - 1.124 0.686 -1.676
ENSG00000157193 E060 0.0000000       1 53289332 53289566 235 -      
ENSG00000157193 E061 0.0000000       1 53289567 53289689 123 -      
ENSG00000157193 E062 0.0000000       1 53291789 53291790 2 -      
ENSG00000157193 E063 0.0000000       1 53291791 53291917 127 -      
ENSG00000157193 E064 0.1308632 0.0122434162 2.011195e-01   1 53291918 53292028 111 - 0.000 0.141 10.901
ENSG00000157193 E065 0.9640303 0.1552839498 6.392544e-01 8.569834e-01 1 53292029 53292292 264 - 0.250 0.333 0.569
ENSG00000157193 E066 0.0000000       1 53295799 53296104 306 -      
ENSG00000157193 E067 0.0000000       1 53312969 53313143 175 -      
ENSG00000157193 E068 0.2281253 0.0154135935 7.614086e-01   1 53313573 53313743 171 - 0.118 0.000 -9.690
ENSG00000157193 E069 7.3008135 0.0044308926 1.501957e-01 4.483553e-01 1 53326873 53326992 120 - 0.936 0.778 -0.609
ENSG00000157193 E070 0.8501969 0.0127734528 4.480078e-01 7.463891e-01 1 53327258 53327463 206 - 0.210 0.333 0.891
ENSG00000157193 E071 12.6703637 0.0024705090 1.209074e-02 1.051862e-01 1 53327789 53328469 681 - 1.167 0.939 -0.832

Help

Please Click HERE to learn more details about the results from DEXseq.