ENSG00000170348

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303575 ENSG00000170348 No_inf pgwt_inf TMED10 protein_coding protein_coding 146.9169 95.77151 171.9087 6.036348 1.952898 0.8439073 77.60593 72.14795 78.16832 1.169666 1.005225 0.1156102 0.5650833 0.763425 0.454725 -0.308700 3.512709e-01 2.781044e-08 FALSE TRUE
ENST00000555085 ENSG00000170348 No_inf pgwt_inf TMED10 protein_coding retained_intron 146.9169 95.77151 171.9087 6.036348 1.952898 0.8439073 21.18311 0.00000 32.90494 0.000000 4.535796 11.6845267 0.1223500 0.000000 0.190700 0.190700 2.781044e-08 2.781044e-08 FALSE FALSE
ENST00000557670 ENSG00000170348 No_inf pgwt_inf TMED10 protein_coding protein_coding_CDS_not_defined 146.9169 95.77151 171.9087 6.036348 1.952898 0.8439073 46.88807 22.63080 59.70879 6.661873 3.624194 1.3992597 0.3040083 0.226375 0.348050 0.121675 9.928472e-01 2.781044e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000170348 E001 994.9592852 0.0023259359 8.656580e-07 5.013381e-05 14 75131469 75133937 2469 - 2.951 3.044 0.310
ENSG00000170348 E002 135.2164655 0.0042658225 5.393679e-01 8.047852e-01 14 75133938 75134355 418 - 2.107 2.161 0.183
ENSG00000170348 E003 94.0488544 0.0002939141 3.078806e-02 1.872826e-01 14 75134356 75134439 84 - 1.994 1.959 -0.117
ENSG00000170348 E004 90.5992965 0.0001714619 6.333415e-04 1.264955e-02 14 75134440 75134499 60 - 1.996 1.920 -0.253
ENSG00000170348 E005 353.1337115 0.0002428524 6.041151e-05 1.954299e-03 14 75134500 75135006 507 - 2.563 2.533 -0.100
ENSG00000170348 E006 0.3940400 0.0159539376 7.530652e-02   14 75135663 75135759 97 - 0.000 0.262 12.443
ENSG00000170348 E007 135.7039352 0.0011708294 1.229885e-04 3.487626e-03 14 75135760 75135886 127 - 2.171 2.093 -0.261
ENSG00000170348 E008 0.6221581 0.0203833244 5.336671e-01   14 75139074 75139171 98 - 0.157 0.262 0.930
ENSG00000170348 E009 0.0000000       14 75147555 75147663 109 -      
ENSG00000170348 E010 96.5070555 0.0035726473 3.967836e-02 2.176043e-01 14 75147664 75147737 74 - 2.011 1.963 -0.161
ENSG00000170348 E011 0.3759015 0.1976926011 5.362127e-01   14 75147738 75147781 44 - 0.085 0.191 1.344
ENSG00000170348 E012 0.0000000       14 75147833 75147897 65 -      
ENSG00000170348 E013 57.9777897 0.0011028151 2.515635e-01 5.785928e-01 14 75152032 75152143 112 - 1.777 1.762 -0.051
ENSG00000170348 E014 0.1311489 0.0122941636 4.567338e-01   14 75175921 75176354 434 - 0.000 0.106 10.886
ENSG00000170348 E015 0.0000000       14 75176355 75176612 258 -      

Help

Please Click HERE to learn more details about the results from DEXseq.