ENSG00000172292

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305747 ENSG00000172292 No_inf pgwt_inf CERS6 protein_coding protein_coding 17.95716 14.79588 18.46293 0.7416241 0.5278907 0.3192428 13.325718 7.162836 16.790218 0.9136185 1.163729 1.2278644 0.7274417 0.49605 0.909175 0.413125 4.211809e-01 1.006015e-06 FALSE TRUE
ENST00000392687 ENSG00000172292 No_inf pgwt_inf CERS6 protein_coding protein_coding 17.95716 14.79588 18.46293 0.7416241 0.5278907 0.3192428 1.900841 1.262183 1.672712 0.7343258 1.017733 0.4034828 0.1032833 0.07960 0.090825 0.011225 1.000000e+00 1.006015e-06 FALSE TRUE
MSTRG.17186.3 ENSG00000172292 No_inf pgwt_inf CERS6 protein_coding   17.95716 14.79588 18.46293 0.7416241 0.5278907 0.3192428 2.730603 6.370859 0.000000 1.0223493 0.000000 -9.3176068 0.1692750 0.42435 0.000000 -0.424350 1.006015e-06 1.006015e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000172292 E001 0.6058037 0.0160627696 9.894481e-01   2 168456249 168456271 23 + 0.203 0.205 0.010
ENSG00000172292 E002 17.5478580 0.0015872766 2.166866e-02 1.513860e-01 2 168456272 168456618 347 + 1.329 1.163 -0.586
ENSG00000172292 E003 9.6448476 0.0987912824 1.987262e-01 5.165286e-01 2 168547596 168547701 106 + 1.099 0.899 -0.741
ENSG00000172292 E004 12.0295277 0.0013421549 2.062288e-02 1.468713e-01 2 168561192 168561322 131 + 1.186 0.988 -0.717
ENSG00000172292 E005 9.5788995 0.0017723506 1.829867e-01 4.958415e-01 2 168630985 168631042 58 + 1.070 0.946 -0.459
ENSG00000172292 E006 10.1141630 0.0014238619 2.689130e-02 1.730529e-01 2 168691034 168691084 51 + 1.119 0.915 -0.751
ENSG00000172292 E007 12.6622455 0.0038474455 7.532023e-02 3.122250e-01 2 168694959 168695051 93 + 1.192 1.039 -0.550
ENSG00000172292 E008 15.9829804 0.0010622051 2.969763e-01 6.247386e-01 2 168715001 168715129 129 + 1.258 1.180 -0.277
ENSG00000172292 E009 13.6558924 0.0012021463 8.670136e-01 9.576542e-01 2 168717872 168717978 107 + 1.169 1.153 -0.054
ENSG00000172292 E010 0.3769827 0.0165347969 3.568328e-01   2 168748169 168748194 26 + 0.079 0.205 1.595
ENSG00000172292 E011 15.7903344 0.0009186711 5.864058e-01 8.303538e-01 2 168765592 168765748 157 + 1.239 1.197 -0.148
ENSG00000172292 E012 0.1315150 0.0122185484 3.489870e-01   2 168766322 168766345 24 + 0.000 0.114 8.835
ENSG00000172292 E013 201.1724199 0.0001552597 5.647306e-08 4.198780e-06 2 168769510 168775134 5625 + 2.271 2.340 0.230

Help

Please Click HERE to learn more details about the results from DEXseq.