ENSG00000175354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309660 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 2.8062751 2.436502 3.212554 0.3328124 0.2943981 0.3974843 0.07634167 0.082625 0.089650 0.007025 1.00000000 0.01002513 FALSE  
ENST00000327283 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 5.6557098 2.782104 8.322207 1.6163327 1.7054072 1.5773462 0.16381667 0.102425 0.232550 0.130125 0.97165384 0.01002513 FALSE  
ENST00000585666 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 0.6040470 1.812141 0.000000 0.4111359 0.0000000 -7.5094907 0.02093333 0.062800 0.000000 -0.062800 0.01002513 0.01002513 FALSE  
ENST00000587703 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 0.7250274 2.175082 0.000000 2.1750823 0.0000000 -7.7715438 0.02010000 0.060300 0.000000 -0.060300 0.99284725 0.01002513 FALSE  
ENST00000589444 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding retained_intron 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 4.1583841 5.277528 4.232306 0.5409839 0.1740511 -0.3177446 0.12145000 0.180400 0.118125 -0.062275 0.99284725 0.01002513    
ENST00000591901 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding protein_coding 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 2.3128520 1.817035 3.669572 0.4188158 1.3165979 1.0100336 0.06567500 0.064350 0.098550 0.034200 0.99284725 0.01002513 FALSE  
ENST00000643900 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding protein_coding_CDS_not_defined 45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 11.7631512 0.000000 0.000000 0.0000000 0.0000000 0.0000000 0.06852500 0.000000 0.000000 0.000000   0.01002513    
MSTRG.13664.1 ENSG00000175354 No_inf pgwt_inf PTPN2 protein_coding   45.39369 29.73497 35.91504 2.154903 1.414895 0.2723439 13.7373130 10.016623 13.189816 1.0208463 1.4995667 0.3966821 0.36378333 0.335625 0.369225 0.033600 1.00000000 0.01002513 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000175354 E001 0.1141751 0.0111536193 0.6812106775   18 12785478 12785480 3 - 0.085 0.000 -10.427
ENSG00000175354 E002 0.1141751 0.0111536193 0.6812106775   18 12785481 12785482 2 - 0.085 0.000 -12.855
ENSG00000175354 E003 0.1141751 0.0111536193 0.6812106775   18 12785483 12785505 23 - 0.085 0.000 -12.855
ENSG00000175354 E004 0.3596331 0.0165152568 0.7415910870   18 12785506 12785533 28 - 0.156 0.106 -0.641
ENSG00000175354 E005 15.5691064 0.0141100501 0.2960288918 0.6238830343 18 12785534 12785684 151 - 1.171 1.266 0.336
ENSG00000175354 E006 41.0923077 0.0003709014 0.2773867943 0.6055904391 18 12785685 12785844 160 - 1.644 1.600 -0.148
ENSG00000175354 E007 49.6833090 0.0016387838 0.0000121659 0.0005018174 18 12785845 12787741 1897 - 1.603 1.794 0.647
ENSG00000175354 E008 2.6538058 0.0054821492 0.0122309792 0.1059001759 18 12788065 12788150 86 - 0.361 0.713 1.681
ENSG00000175354 E009 1.7649413 0.1606925133 0.1303047134 0.4187008060 18 12792152 12792301 150 - 0.556 0.263 -1.641
ENSG00000175354 E010 14.0691390 0.0072083291 0.4492132483 0.7473653785 18 12792302 12793481 1180 - 1.145 1.211 0.234
ENSG00000175354 E011 3.6653055 0.0064691247 0.7783033457 0.9229551760 18 12793482 12793574 93 - 0.649 0.689 0.167
ENSG00000175354 E012 3.9265815 0.0141543787 0.5221722461 0.7940675433 18 12793575 12793834 260 - 0.649 0.735 0.359
ENSG00000175354 E013 6.3107585 0.0116784516 0.8004297828 0.9315114139 18 12793835 12794111 277 - 0.874 0.851 -0.088
ENSG00000175354 E014 10.5280246 0.0014349974 0.4667749486 0.7585677595 18 12794112 12794383 272 - 1.088 1.030 -0.212
ENSG00000175354 E015 29.1652120 0.0004826333 0.0252620269 0.1668192510 18 12794384 12794485 102 - 1.530 1.414 -0.397
ENSG00000175354 E016 12.6618480 0.0012684938 0.9792355039 0.9973230220 18 12801970 12801988 19 - 1.132 1.138 0.025
ENSG00000175354 E017 31.5001642 0.0007945413 0.2683384526 0.5964531376 18 12801989 12802151 163 - 1.535 1.483 -0.180
ENSG00000175354 E018 0.0000000       18 12802152 12802153 2 -      
ENSG00000175354 E019 0.1138060 0.0111732612 0.6811028982   18 12814197 12814202 6 - 0.085 0.000 -12.855
ENSG00000175354 E020 23.1971259 0.0006986525 0.5327101850 0.8004531614 18 12814203 12814324 122 - 1.363 1.405 0.146
ENSG00000175354 E021 14.4776159 0.0010703121 0.9298062803 0.9803718223 18 12814325 12814355 31 - 1.190 1.188 -0.006
ENSG00000175354 E022 11.6457836 0.0011882574 0.6297161273 0.8518313516 18 12817156 12817180 25 - 1.117 1.082 -0.126
ENSG00000175354 E023 19.9570657 0.0007091343 0.9594175365 0.9901817620 18 12817181 12817265 85 - 1.320 1.321 0.006
ENSG00000175354 E024 20.3920068 0.0006878660 0.6272556167 0.8507518831 18 12817266 12817365 100 - 1.342 1.316 -0.091
ENSG00000175354 E025 1.1793579 0.2608477492 0.0052306742 0.0599213572 18 12818944 12819213 270 - 0.000 0.543 14.937
ENSG00000175354 E026 0.8835199 0.3460848439 0.2692379389 0.5972739334 18 12819214 12819282 69 - 0.156 0.378 1.681
ENSG00000175354 E027 1.0604664 0.0115333750 0.1743130145 0.4841258077 18 12821336 12821425 90 - 0.400 0.192 -1.448
ENSG00000175354 E028 0.0000000       18 12825804 12825809 6 -      
ENSG00000175354 E029 16.2495830 0.0016326182 0.5929134504 0.8340166616 18 12825810 12825944 135 - 1.252 1.218 -0.119
ENSG00000175354 E030 15.2978893 0.0009938130 0.1027457748 0.3693355989 18 12830943 12831041 99 - 1.262 1.147 -0.408
ENSG00000175354 E031 9.0107828 0.0015890637 0.9330834152 0.9814312868 18 12836791 12836823 33 - 0.994 1.006 0.046
ENSG00000175354 E032 13.2484406 0.0010902624 0.8347387374 0.9447582427 18 12836824 12836891 68 - 1.158 1.147 -0.040
ENSG00000175354 E033 0.0000000       18 12839502 12839557 56 -      
ENSG00000175354 E034 0.3772738 0.1985489097 0.4904577256   18 12840714 12840962 249 - 0.085 0.192 1.360
ENSG00000175354 E035 0.1141751 0.0111536193 0.6812106775   18 12843905 12843981 77 - 0.085 0.000 -12.855
ENSG00000175354 E036 10.5812266 0.0047373355 0.1021649560 0.3683367546 18 12859164 12859254 91 - 1.125 0.982 -0.520
ENSG00000175354 E037 0.3943257 0.0159087889 0.0649454156   18 12860472 12860525 54 - 0.000 0.263 14.038
ENSG00000175354 E038 0.2462566 0.0160945461 0.8535429693   18 12862084 12862639 556 - 0.085 0.106 0.359
ENSG00000175354 E039 0.1316618 0.0123377693 0.4227781579   18 12862640 12862716 77 - 0.000 0.106 12.583
ENSG00000175354 E040 0.0000000       18 12862717 12862744 28 -      
ENSG00000175354 E041 0.3586193 0.0168164412 0.7412592934   18 12863197 12864194 998 - 0.156 0.106 -0.641
ENSG00000175354 E042 0.1316618 0.0123377693 0.4227781579   18 12869025 12869122 98 - 0.000 0.106 12.583
ENSG00000175354 E043 0.1316618 0.0123377693 0.4227781579   18 12872228 12872269 42 - 0.000 0.106 12.583
ENSG00000175354 E044 0.1141751 0.0111536193 0.6812106775   18 12880496 12880692 197 - 0.085 0.000 -12.855
ENSG00000175354 E045 0.1145948 0.0111826572 0.6811488855   18 12883618 12884072 455 - 0.085 0.000 -12.855
ENSG00000175354 E046 8.0946990 0.0017676277 0.3823295356 0.6986212903 18 12884073 12884338 266 - 0.994 0.914 -0.298
ENSG00000175354 E047 0.0000000       18 12929499 12929643 145 -      

Help

Please Click HERE to learn more details about the results from DEXseq.