ENSG00000176170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323374 ENSG00000176170 No_inf pgwt_inf SPHK1 protein_coding protein_coding 33.33155 11.68833 50.45527 0.08259504 1.234058 2.108988 5.504254 1.8989552 9.157334 0.6387988 1.784239 2.263719 0.16280833 0.161800 0.181750 0.019950 1.00000000 0.04091468 FALSE TRUE
ENST00000392496 ENSG00000176170 No_inf pgwt_inf SPHK1 protein_coding protein_coding 33.33155 11.68833 50.45527 0.08259504 1.234058 2.108988 9.413634 4.5984839 12.976757 1.5589628 1.490725 1.494677 0.31251667 0.393850 0.258650 -0.135200 0.99284725 0.04091468 FALSE TRUE
ENST00000587167 ENSG00000176170 No_inf pgwt_inf SPHK1 protein_coding retained_intron 33.33155 11.68833 50.45527 0.08259504 1.234058 2.108988 1.919369 0.5050385 3.720325 0.2920476 1.594776 2.856549 0.05158333 0.043500 0.072000 0.028500 0.99284725 0.04091468   FALSE
ENST00000590959 ENSG00000176170 No_inf pgwt_inf SPHK1 protein_coding protein_coding 33.33155 11.68833 50.45527 0.08259504 1.234058 2.108988 1.579341 3.1982291 0.000000 1.6276906 0.000000 -8.325633 0.10434167 0.273225 0.000000 -0.273225 0.14597584 0.04091468 FALSE TRUE
ENST00000591762 ENSG00000176170 No_inf pgwt_inf SPHK1 protein_coding retained_intron 33.33155 11.68833 50.45527 0.08259504 1.234058 2.108988 2.871528 0.9807297 4.491485 0.3989704 0.377620 2.183838 0.08594167 0.084050 0.089075 0.005025 0.99323661 0.04091468 FALSE TRUE
ENST00000592299 ENSG00000176170 No_inf pgwt_inf SPHK1 protein_coding protein_coding 33.33155 11.68833 50.45527 0.08259504 1.234058 2.108988 11.748426 0.2892452 19.878409 0.2892452 1.417910 6.054456 0.27137500 0.025175 0.393975 0.368800 0.04091468 0.04091468 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000176170 E001 0.1141751 0.0111382301 1.0000000000   17 76376584 76376660 77 + 0.050 0.000 -9.559
ENSG00000176170 E002 0.1316618 0.0122640420 0.0982966467   17 76376661 76376812 152 + 0.000 0.174 13.197
ENSG00000176170 E003 0.1311489 0.0122146709 0.0983286940   17 76377304 76377404 101 + 0.000 0.174 13.198
ENSG00000176170 E004 0.4734493 0.0253945651 0.7729940385   17 76379387 76379727 341 + 0.135 0.174 0.425
ENSG00000176170 E005 0.4746548 0.0213240439 0.7719716722   17 76381537 76381658 122 + 0.135 0.174 0.425
ENSG00000176170 E006 0.2631768 0.0161574303 0.0206835045   17 76381771 76381978 208 + 0.000 0.297 14.124
ENSG00000176170 E007 0.7188239 0.0144655305 0.4372360599 0.738901521 17 76382977 76383529 553 + 0.173 0.297 1.010
ENSG00000176170 E008 0.0000000       17 76383919 76383977 59 +      
ENSG00000176170 E009 0.2284008 0.0157699365 1.0000000000   17 76384609 76384620 12 + 0.095 0.000 -12.289
ENSG00000176170 E010 1.7131378 0.0086734806 0.0241696477 0.161962878 17 76384621 76384649 29 + 0.452 0.000 -14.753
ENSG00000176170 E011 13.0495095 0.0015974954 0.0004404587 0.009555453 17 76384650 76384806 157 + 1.136 0.734 -1.520
ENSG00000176170 E012 11.9105540 0.0385627202 0.4039448944 0.714327075 17 76384807 76385169 363 + 1.060 0.948 -0.416
ENSG00000176170 E013 6.6418930 0.0020636954 0.2557712358 0.583007242 17 76385292 76385450 159 + 0.844 0.693 -0.604
ENSG00000176170 E014 22.0779138 0.0006316181 0.8224213465 0.939663381 17 76385451 76385654 204 + 1.291 1.272 -0.068
ENSG00000176170 E015 10.8869005 0.0013903664 0.5226443682 0.794324666 17 76385655 76385942 288 + 1.017 0.948 -0.257
ENSG00000176170 E016 3.1218615 0.0052484698 0.0798328884 0.322762514 17 76385943 76385984 42 + 0.488 0.734 1.093
ENSG00000176170 E017 9.5076022 0.0014747904 0.0947420433 0.353964115 17 76385985 76386022 38 + 0.907 1.072 0.612
ENSG00000176170 E018 17.6389299 0.0008770434 0.1255557211 0.410750663 17 76386023 76386137 115 + 1.166 1.283 0.412
ENSG00000176170 E019 23.8120278 0.0010538045 0.4709843635 0.761810767 17 76386221 76386315 95 + 1.307 1.355 0.166
ENSG00000176170 E020 1.4029141 0.0195195802 0.7868569910 0.926126648 17 76386316 76386392 77 + 0.346 0.297 -0.312
ENSG00000176170 E021 31.7709508 0.0004380968 0.4578113406 0.753036396 17 76386393 76386508 116 + 1.448 1.399 -0.169
ENSG00000176170 E022 0.6846008 0.3008508391 0.4239225958 0.729074899 17 76386509 76386561 53 + 0.239 0.000 -13.153
ENSG00000176170 E023 167.6212188 0.0001219268 0.4412082635 0.741460061 17 76386806 76387860 1055 + 2.144 2.157 0.042

Help

Please Click HERE to learn more details about the results from DEXseq.