ENSG00000177885

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316804 ENSG00000177885 No_inf pgwt_inf GRB2 protein_coding protein_coding 90.22282 77.60868 95.77783 1.117664 0.8941335 0.3034384 72.67608 47.51744 91.41520 3.727063 2.868349 0.943831 0.7945333 0.611525 0.955175 0.343650 0.12904276 0.04601508 FALSE TRUE
ENST00000392564 ENSG00000177885 No_inf pgwt_inf GRB2 protein_coding protein_coding 90.22282 77.60868 95.77783 1.117664 0.8941335 0.3034384 16.16594 28.94262 3.33844 3.289351 3.338440 -3.112133 0.1904333 0.373675 0.034150 -0.339525 0.04601508 0.04601508 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000177885 E001 5.5139431 2.557278e-03 5.647748e-01 8.184282e-01 17 75318076 75318096 21 - 0.781 0.846 0.252
ENSG00000177885 E002 84.5916152 3.249770e-04 1.321224e-02 1.111193e-01 17 75318097 75318297 201 - 1.891 1.973 0.274
ENSG00000177885 E003 317.1802375 6.800747e-05 1.889928e-08 1.555484e-06 17 75318298 75318754 457 - 2.457 2.547 0.298
ENSG00000177885 E004 74.2336245 3.600823e-04 4.278634e-02 2.272037e-01 17 75318755 75318796 42 - 1.840 1.912 0.240
ENSG00000177885 E005 341.9132393 6.269466e-05 4.550130e-01 7.514098e-01 17 75318797 75319478 682 - 2.529 2.541 0.039
ENSG00000177885 E006 135.9763744 1.242161e-03 5.025088e-01 7.824209e-01 17 75319479 75319830 352 - 2.127 2.146 0.065
ENSG00000177885 E007 101.4925178 2.134483e-03 5.423221e-01 8.065023e-01 17 75319831 75320010 180 - 2.000 2.022 0.073
ENSG00000177885 E008 189.3439030 8.119630e-05 2.100341e-02 1.485857e-01 17 75320011 75320340 330 - 2.302 2.253 -0.163
ENSG00000177885 E009 41.5023636 5.299223e-04 1.607370e-02 1.258723e-01 17 75320341 75320344 4 - 1.679 1.566 -0.385
ENSG00000177885 E010 153.5980686 1.215572e-03 1.939399e-01 5.099805e-01 17 75320345 75320553 209 - 2.205 2.170 -0.118
ENSG00000177885 E011 101.4703017 1.479367e-04 1.684736e-01 4.752932e-01 17 75321659 75321794 136 - 2.029 1.989 -0.136
ENSG00000177885 E012 48.3890141 3.132320e-04 6.619101e-01 8.680767e-01 17 75321795 75321827 33 - 1.702 1.684 -0.063
ENSG00000177885 E013 93.0026999 1.627240e-04 8.587011e-01 9.545874e-01 17 75325898 75326020 123 - 1.975 1.970 -0.018
ENSG00000177885 E014 0.1315150 1.228546e-02 4.314853e-01   17 75326239 75326338 100 - 0.000 0.105 11.009
ENSG00000177885 E015 82.2768480 2.114551e-04 1.828997e-01 4.957576e-01 17 75332700 75332797 98 - 1.941 1.897 -0.147
ENSG00000177885 E016 0.1141751 1.119672e-02 6.679999e-01   17 75387490 75387794 305 - 0.086 0.000 -11.306
ENSG00000177885 E017 0.2456120 1.639206e-02 8.652572e-01   17 75393404 75393550 147 - 0.086 0.105 0.316
ENSG00000177885 E018 108.7897603 1.386285e-04 3.059350e-05 1.101076e-03 17 75393551 75393765 215 - 2.094 1.974 -0.402
ENSG00000177885 E019 0.2453209 1.638393e-02 8.652294e-01   17 75393766 75393864 99 - 0.086 0.105 0.316
ENSG00000177885 E020 0.1138060 1.118422e-02 6.679827e-01   17 75393919 75394033 115 - 0.086 0.000 -11.307
ENSG00000177885 E021 0.5243902 1.575225e-02 2.656998e-02   17 75404841 75405486 646 - 0.000 0.321 12.932
ENSG00000177885 E022 57.2934393 2.422372e-04 2.706209e-04 6.556907e-03 17 75405489 75405769 281 - 1.829 1.684 -0.492

Help

Please Click HERE to learn more details about the results from DEXseq.