ENSG00000181458

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323523 ENSG00000181458 No_inf pgwt_inf TMEM45A protein_coding protein_coding 13.07891 10.61756 17.88762 0.8690476 1.503083 0.7519579 4.6975936 1.4859975 7.358844 1.0331231 0.6095804 2.3003305 0.3475250 0.13810 0.414675 0.276575 7.427005e-01 5.273807e-07 FALSE TRUE
ENST00000449609 ENSG00000181458 No_inf pgwt_inf TMEM45A protein_coding protein_coding 13.07891 10.61756 17.88762 0.8690476 1.503083 0.7519579 0.4733759 0.0000000 1.420128 0.0000000 0.8748352 7.1600003 0.0232750 0.00000 0.069825 0.069825 9.928472e-01 5.273807e-07 FALSE FALSE
ENST00000489060 ENSG00000181458 No_inf pgwt_inf TMEM45A protein_coding retained_intron 13.07891 10.61756 17.88762 0.8690476 1.503083 0.7519579 2.2303236 4.8696984 0.000000 0.7316529 0.0000000 -8.9306482 0.2028083 0.45025 0.000000 -0.450250 5.273807e-07 5.273807e-07 FALSE TRUE
MSTRG.20475.1 ENSG00000181458 No_inf pgwt_inf TMEM45A protein_coding   13.07891 10.61756 17.88762 0.8690476 1.503083 0.7519579 3.0617614 3.3878205 3.749016 1.1422488 0.4592610 0.1457452 0.2356000 0.30550 0.215900 -0.089600 9.928472e-01 5.273807e-07 FALSE TRUE
MSTRG.20475.7 ENSG00000181458 No_inf pgwt_inf TMEM45A protein_coding   13.07891 10.61756 17.88762 0.8690476 1.503083 0.7519579 1.7981333 0.6549381 3.333441 0.6549381 0.3535668 2.3300419 0.1390000 0.07955 0.192525 0.112975 5.671625e-01 5.273807e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgwt.inf No.inf log2fold_No.inf_pgwt.inf
ENSG00000181458 E001 0.3769801 0.1080019543 0.199766869   3 100492587 100492618 32 + 0.064 0.245 2.268
ENSG00000181458 E002 0.3769801 0.1080019543 0.199766869   3 100492619 100492650 32 + 0.064 0.245 2.268
ENSG00000181458 E003 0.4911552 0.0209196420 0.385035572   3 100492651 100492659 9 + 0.119 0.245 1.268
ENSG00000181458 E004 7.7455467 0.0019593668 0.995309311 1.00000000 3 100492660 100492928 269 + 0.917 0.915 -0.008
ENSG00000181458 E005 0.1139502 0.0111399326 1.000000000   3 100498151 100498192 42 + 0.064 0.000 -9.767
ENSG00000181458 E006 0.4571201 0.2374233323 0.334088118   3 100519077 100519238 162 + 0.213 0.000 -11.537
ENSG00000181458 E007 0.7186216 0.0351434035 0.829810258 0.94263689 3 100519239 100519286 48 + 0.212 0.245 0.267
ENSG00000181458 E008 1.1757923 0.0273457025 0.512260878 0.78790870 3 100519287 100519316 30 + 0.355 0.245 -0.733
ENSG00000181458 E009 3.8561597 0.0039362611 0.314740396 0.64075428 3 100519462 100519532 71 + 0.619 0.745 0.531
ENSG00000181458 E010 3.7880840 0.0043227409 0.592035889 0.83345666 3 100519533 100519608 76 + 0.680 0.606 -0.317
ENSG00000181458 E011 13.2724526 0.0011710887 0.013122305 0.11067853 3 100555209 100555401 193 + 1.186 0.971 -0.781
ENSG00000181458 E012 21.8550446 0.0008475927 0.046363389 0.23704583 3 100556760 100556972 213 + 1.369 1.239 -0.456
ENSG00000181458 E013 17.6731704 0.0008727856 0.370622239 0.68900612 3 100558405 100558589 185 + 1.264 1.199 -0.228
ENSG00000181458 E014 12.8894765 0.0012981144 0.760111731 0.91465815 3 100568822 100568923 102 + 1.108 1.131 0.083
ENSG00000181458 E015 7.3392567 0.0019698662 0.241574258 0.56758403 3 100568924 100568967 44 + 0.855 0.971 0.442
ENSG00000181458 E016 1.1741845 0.0570505584 0.528998323 0.79811303 3 100570609 100571029 421 + 0.355 0.245 -0.732
ENSG00000181458 E017 0.1141751 0.0112975073 1.000000000   3 100571030 100571319 290 + 0.064 0.000 -9.767
ENSG00000181458 E018 0.0000000       3 100571320 100574659 3340 +      
ENSG00000181458 E019 28.3542366 0.0011713145 0.001501299 0.02444723 3 100576925 100577444 520 + 1.381 1.542 0.554

Help

Please Click HERE to learn more details about the results from DEXseq.