ENSG00000000457

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367770 ENSG00000000457 No_inf pgKDN_inf SCYL3 protein_coding protein_coding 8.875521 12.72588 7.882921 0.3842871 0.292432 -0.6902672 1.292011 3.578088 0.000000 1.1753351 0.0000000 -8.4870713 0.1052500 0.277525 0.000000 -0.277525 0.0003712431 0.0003712431 FALSE TRUE
ENST00000367771 ENSG00000000457 No_inf pgKDN_inf SCYL3 protein_coding protein_coding 8.875521 12.72588 7.882921 0.3842871 0.292432 -0.6902672 2.383483 4.293519 1.481084 0.2515225 0.1095316 -1.5291554 0.2554833 0.339000 0.187600 -0.151400 0.4485261620 0.0003712431 FALSE TRUE
ENST00000367772 ENSG00000000457 No_inf pgKDN_inf SCYL3 protein_coding protein_coding 8.875521 12.72588 7.882921 0.3842871 0.292432 -0.6902672 0.258276 0.000000 0.774828 0.0000000 0.4869437 6.2943047 0.0319500 0.000000 0.095850 0.095850 0.3786301682 0.0003712431 FALSE TRUE
MSTRG.2229.4 ENSG00000000457 No_inf pgKDN_inf SCYL3 protein_coding   8.875521 12.72588 7.882921 0.3842871 0.292432 -0.6902672 2.894031 2.610703 4.455877 0.9864451 1.0220761 0.7689897 0.3353583 0.211225 0.558350 0.347125 0.4016489515 0.0003712431 FALSE TRUE
MSTRG.2229.5 ENSG00000000457 No_inf pgKDN_inf SCYL3 protein_coding   8.875521 12.72588 7.882921 0.3842871 0.292432 -0.6902672 2.047721 2.243568 1.171132 0.8391388 0.9279697 -0.9320406 0.2719667 0.172250 0.158225 -0.014025 0.8179193017 0.0003712431 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000000457 E001 36.4626992 0.0006111363 1.554708e-05 0.000498227 1 169849631 169853073 3443 - 1.381 1.604 0.764
ENSG00000000457 E002 0.0000000       1 169853074 169853294 221 -      
ENSG00000000457 E003 0.0000000       1 169853295 169853313 19 -      
ENSG00000000457 E004 0.0000000       1 169853314 169853772 459 -      
ENSG00000000457 E005 18.8270428 0.0580611581 8.275691e-01 0.937583149 1 169854270 169854510 241 - 1.284 1.261 -0.082
ENSG00000000457 E006 38.1056337 0.0003982817 4.126908e-01 0.693784207 1 169854511 169854964 454 - 1.536 1.575 0.131
ENSG00000000457 E007 1.1045470 0.0121310896 5.043060e-01 0.763482709 1 169855796 169855957 162 - 0.376 0.272 -0.662
ENSG00000000457 E008 9.3106085 0.0570072966 6.488504e-01 0.851902898 1 169859041 169859118 78 - 0.950 1.002 0.193
ENSG00000000457 E009 8.7268550 0.0020424896 1.495024e-01 0.411832130 1 169859119 169859212 94 - 0.857 1.002 0.547
ENSG00000000457 E010 8.1010179 0.0023485506 1.935622e-01 0.473364708 1 169862613 169862797 185 - 0.836 0.971 0.514
ENSG00000000457 E011 7.7808134 0.0022533932 4.513752e-01 0.724489543 1 169864369 169864508 140 - 0.967 0.891 -0.283
ENSG00000000457 E012 6.6683039 0.0021655438 4.121006e-01 0.693551154 1 169866896 169866973 78 - 0.915 0.829 -0.331
ENSG00000000457 E013 9.0023537 0.0016260797 1.764823e-01 0.450638855 1 169868928 169869039 112 - 1.054 0.929 -0.464
ENSG00000000457 E014 1.3597895 0.1737373164 8.584713e-01 0.950656844 1 169869040 169869128 89 - 0.376 0.346 -0.175
ENSG00000000457 E015 9.2687746 0.0098002910 5.286424e-01 0.780204708 1 169870255 169870357 103 - 1.027 0.963 -0.236
ENSG00000000457 E016 6.7757763 0.0154577189 2.405029e-01 0.529721272 1 169873696 169873752 57 - 0.950 0.818 -0.507
ENSG00000000457 E017 9.8461166 0.0016754537 5.583778e-02 0.235443285 1 169875978 169876091 114 - 1.115 0.946 -0.621
ENSG00000000457 E018 9.4353692 0.0015468115 3.894110e-03 0.041658717 1 169878634 169878819 186 - 1.149 0.891 -0.946
ENSG00000000457 E019 0.3816610 0.0247262528 3.216221e-01   1 169888664 169888675 12 - 0.000 0.182 9.257
ENSG00000000457 E020 7.2595243 0.0026596378 1.609508e-01 0.428974157 1 169888676 169888890 215 - 0.982 0.840 -0.540
ENSG00000000457 E021 0.3728195 0.0165529530 1.000000e+00   1 169893476 169893512 37 - 0.128 0.130 0.016
ENSG00000000457 E022 3.0660922 0.0057662980 1.420778e-01 0.401006068 1 169893788 169893959 172 - 0.710 0.514 -0.868
ENSG00000000457 E023 0.0000000       1 169894007 169894267 261 -      

Help

Please Click HERE to learn more details about the results from DEXseq.