ENSG00000005448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348227 ENSG00000005448 No_inf pgKDN_inf WDR54 protein_coding protein_coding 13.98006 15.30077 13.6649 1.992211 0.6567425 -0.1630167 10.4776361 7.800093 12.4529158 0.2555944 0.5390875 0.674230 0.77354167 0.539475 0.9126 0.373125 0.000572535 0.000572535 FALSE TRUE
ENST00000409791 ENSG00000005448 No_inf pgKDN_inf WDR54 protein_coding protein_coding 13.98006 15.30077 13.6649 1.992211 0.6567425 -0.1630167 1.1252353 2.595348 0.2105187 1.0403529 0.2105187 -3.562503 0.07095833 0.157550 0.0149 -0.142650 0.283369693 0.000572535 FALSE TRUE
ENST00000469932 ENSG00000005448 No_inf pgKDN_inf WDR54 protein_coding retained_intron 13.98006 15.30077 13.6649 1.992211 0.6567425 -0.1630167 0.3468751 1.040625 0.0000000 0.4082087 0.0000000 -6.715104 0.02150000 0.064500 0.0000 -0.064500 0.100421495 0.000572535 FALSE FALSE
ENST00000482605 ENSG00000005448 No_inf pgKDN_inf WDR54 protein_coding retained_intron 13.98006 15.30077 13.6649 1.992211 0.6567425 -0.1630167 0.5765778 1.729733 0.0000000 1.0260557 0.0000000 -7.442722 0.03145000 0.094350 0.0000 -0.094350 0.465820422 0.000572535   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000005448 E001 0.0000000       2 74421678 74421728 51 +      
ENSG00000005448 E002 0.0000000       2 74421729 74421729 1 +      
ENSG00000005448 E003 0.5082629 0.255020659 0.103708918 0.33654854 2 74421730 74421741 12 + 0.000 0.287 13.190
ENSG00000005448 E004 0.5082629 0.255020659 0.103708918 0.33654854 2 74421742 74421743 2 + 0.000 0.287 13.369
ENSG00000005448 E005 0.8728665 0.032712600 0.324058664 0.61655145 2 74421744 74421758 15 + 0.180 0.337 1.194
ENSG00000005448 E006 1.4717239 0.040431251 0.856866793 0.94978881 2 74421759 74421763 5 + 0.404 0.381 -0.128
ENSG00000005448 E007 1.7159902 0.015950345 0.836382637 0.94132971 2 74421764 74421765 2 + 0.446 0.421 -0.128
ENSG00000005448 E008 5.0356021 0.003049832 0.913639503 0.97278122 2 74421766 74421816 51 + 0.768 0.789 0.083
ENSG00000005448 E009 2.0979080 0.015543440 0.629213580 0.84097672 2 74421817 74422119 303 + 0.446 0.524 0.386
ENSG00000005448 E010 0.6166738 0.016225140 0.748853797 0.90092975 2 74422120 74422152 33 + 0.179 0.231 0.457
ENSG00000005448 E011 5.3790944 0.002703037 0.494353804 0.75587014 2 74422153 74422174 22 + 0.838 0.772 -0.260
ENSG00000005448 E012 9.9224843 0.001993353 0.681637735 0.86827810 2 74422175 74422375 201 + 1.051 1.025 -0.093
ENSG00000005448 E013 1.7411384 0.017103214 0.164769003 0.43419414 2 74422376 74422869 494 + 0.306 0.524 1.194
ENSG00000005448 E014 6.5091234 0.028198645 0.984577799 0.99885670 2 74422870 74422932 63 + 0.869 0.878 0.035
ENSG00000005448 E015 0.8875663 0.040590518 0.008135979 0.06988468 2 74422933 74423111 179 + 0.000 0.421 14.176
ENSG00000005448 E016 0.3703650 0.016574466 0.656784135   2 74423191 74423318 128 + 0.099 0.167 0.872
ENSG00000005448 E017 6.6748444 0.002619419 0.215345176 0.50111864 2 74423319 74423385 67 + 0.804 0.941 0.524
ENSG00000005448 E018 0.1268540 0.012290090 0.601238071   2 74423386 74423477 92 + 0.000 0.091 11.371
ENSG00000005448 E019 8.2567481 0.001699757 0.367954858 0.65656995 2 74423478 74423531 54 + 0.912 1.006 0.350
ENSG00000005448 E020 0.7436814 0.014584453 0.494586883 0.75596051 2 74423532 74423854 323 + 0.179 0.287 0.872
ENSG00000005448 E021 13.7826259 0.001893318 0.346470165 0.63719224 2 74423855 74423982 128 + 1.123 1.204 0.287
ENSG00000005448 E022 0.0000000       2 74424873 74424874 2 +      
ENSG00000005448 E023 10.5491651 0.001319658 0.920177019 0.97521456 2 74424875 74424975 101 + 1.060 1.062 0.006
ENSG00000005448 E024 0.3809703 0.018334133 0.127513778   2 74424976 74425074 99 + 0.000 0.231 12.955
ENSG00000005448 E025 6.7529298 0.019366917 0.981616225 0.99821803 2 74425075 74425096 22 + 0.884 0.892 0.029
ENSG00000005448 E026 19.0446412 0.001623794 0.052822684 0.22844241 2 74425097 74425237 141 + 1.357 1.246 -0.388
ENSG00000005448 E027 9.9154479 0.053432495 0.619492905 0.83541172 2 74425417 74425491 75 + 1.061 1.015 -0.165
ENSG00000005448 E028 6.5859539 0.058586753 0.347492034 0.63814346 2 74425570 74425639 70 + 0.938 0.821 -0.451
ENSG00000005448 E029 4.7451312 0.010060265 0.145157164 0.40545781 2 74425640 74425755 116 + 0.838 0.676 -0.652

Help

Please Click HERE to learn more details about the results from DEXseq.