ENSG00000006125

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587805 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding protein_coding 27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 2.891068 2.724780 3.446138 0.4694313 0.4730209 0.3377364 0.10440833 0.119500 0.114575 -0.004925 1.000000e+00 1.190984e-08 FALSE FALSE
ENST00000610402 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding protein_coding 27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 5.015928 6.477441 5.914848 1.3975453 3.4542621 -0.1308715 0.19103333 0.285750 0.194275 -0.091475 6.922224e-01 1.190984e-08 FALSE TRUE
ENST00000618940 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding protein_coding 27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 1.811171 0.000000 2.136599 0.0000000 2.1365992 7.7459090 0.06408333 0.000000 0.069375 0.069375 8.658918e-01 1.190984e-08 FALSE TRUE
ENST00000621914 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding protein_coding 27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 8.229154 1.962434 14.549565 1.2348984 1.6919550 2.8839184 0.28660833 0.088825 0.486975 0.398150 4.718670e-02 1.190984e-08 FALSE TRUE
MSTRG.12516.14 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding   27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 2.169925 0.000000 2.257395 0.0000000 0.9750227 7.8248920 0.07171667 0.000000 0.076975 0.076975 8.188251e-02 1.190984e-08 FALSE TRUE
MSTRG.12516.28 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding   27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 2.002509 5.431673 0.000000 1.0155508 0.0000000 -9.0879064 0.08730000 0.242725 0.000000 -0.242725 1.190984e-08 1.190984e-08 FALSE TRUE
MSTRG.12516.3 ENSG00000006125 No_inf pgKDN_inf AP2B1 protein_coding   27.69645 22.62487 29.97992 0.4693476 0.5861968 0.4059307 3.526451 4.085300 0.000000 1.3766066 0.0000000 -8.6778252 0.12289167 0.179600 0.000000 -0.179600 1.266801e-02 1.190984e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000006125 E001 0.0000000       17 35578046 35578086 41 +      
ENSG00000006125 E002 0.0000000       17 35578087 35578121 35 +      
ENSG00000006125 E003 0.0000000       17 35586899 35587273 375 +      
ENSG00000006125 E004 0.0000000       17 35587274 35587300 27 +      
ENSG00000006125 E005 0.4882753 0.4815431314 7.632971e-01   17 35587301 35587313 13 + 0.147 0.202 0.558
ENSG00000006125 E006 0.6069134 0.1980729687 9.739862e-01 9.953877e-01 17 35587314 35587321 8 + 0.206 0.202 -0.028
ENSG00000006125 E007 2.5436006 0.0527022553 5.399761e-01 7.881964e-01 17 35587322 35587366 45 + 0.583 0.488 -0.443
ENSG00000006125 E008 3.7509571 0.0191793718 3.680773e-01 6.566342e-01 17 35587367 35587415 49 + 0.719 0.599 -0.513
ENSG00000006125 E009 1.7054871 0.0092732298 8.646852e-01 9.531832e-01 17 35587416 35587428 13 + 0.417 0.444 0.143
ENSG00000006125 E010 0.0000000       17 35587429 35587451 23 +      
ENSG00000006125 E011 0.4896948 0.0161249323 7.057391e-01   17 35587452 35587514 63 + 0.147 0.202 0.558
ENSG00000006125 E012 0.6168311 0.0147604185 3.864554e-01 6.723554e-01 17 35587515 35587530 16 + 0.147 0.277 1.143
ENSG00000006125 E013 0.9789802 0.0116683256 5.945637e-01 8.217091e-01 17 35587531 35587565 35 + 0.257 0.340 0.558
ENSG00000006125 E014 1.0870428 0.0112661395 6.581455e-01 8.570701e-01 17 35587566 35587597 32 + 0.344 0.277 -0.442
ENSG00000006125 E015 0.1170040 0.0116655282 7.934108e-01   17 35587598 35587663 66 + 0.080 0.000 -11.212
ENSG00000006125 E016 0.0000000       17 35587738 35587893 156 +      
ENSG00000006125 E017 0.0000000       17 35588625 35588733 109 +      
ENSG00000006125 E018 4.6384553 0.0030008324 6.079945e-01 8.292158e-01 17 35594008 35594030 23 + 0.719 0.782 0.253
ENSG00000006125 E019 5.5993384 0.0025082826 9.218126e-01 9.757406e-01 17 35594031 35594067 37 + 0.809 0.822 0.051
ENSG00000006125 E020 17.2261630 0.0008160584 4.282979e-01 7.068573e-01 17 35598230 35598335 106 + 1.278 1.224 -0.190
ENSG00000006125 E021 0.1271363 0.0122996814 3.632906e-01   17 35600937 35600985 49 + 0.000 0.113 10.983
ENSG00000006125 E022 0.2444846 0.0162606471 7.673016e-01   17 35600986 35601071 86 + 0.080 0.113 0.558
ENSG00000006125 E023 18.1012173 0.0008374998 6.799401e-01 8.677737e-01 17 35605705 35605840 136 + 1.287 1.261 -0.092
ENSG00000006125 E024 0.0000000       17 35607837 35608055 219 +      
ENSG00000006125 E025 15.5715759 0.0011007362 9.927569e-01 1.000000e+00 17 35608142 35608255 114 + 1.213 1.216 0.010
ENSG00000006125 E026 18.4716402 0.0007586874 1.165248e-02 8.887918e-02 17 35608256 35608387 132 + 1.350 1.175 -0.616
ENSG00000006125 E027 0.0000000       17 35621275 35621363 89 +      
ENSG00000006125 E028 23.4875945 0.0005903565 1.699622e-04 3.665115e-03 17 35624397 35624581 185 + 1.469 1.231 -0.827
ENSG00000006125 E029 8.2611393 0.0017872002 3.684002e-04 6.863241e-03 17 35624582 35624587 6 + 1.083 0.712 -1.416
ENSG00000006125 E030 24.7883010 0.0005681321 1.933254e-02 1.242175e-01 17 35626621 35626842 222 + 1.460 1.320 -0.485
ENSG00000006125 E031 16.1669975 0.0086733313 3.167197e-02 1.681279e-01 17 35627385 35627505 121 + 1.296 1.120 -0.624
ENSG00000006125 E032 19.7608278 0.0006877197 3.245106e-01 6.168865e-01 17 35627631 35627726 96 + 1.338 1.275 -0.222
ENSG00000006125 E033 21.6470551 0.0006508031 2.381370e-02 1.412167e-01 17 35636341 35636456 116 + 1.405 1.261 -0.503
ENSG00000006125 E034 25.5892959 0.0005561806 1.655840e-03 2.207814e-02 17 35639595 35639760 166 + 1.489 1.301 -0.652
ENSG00000006125 E035 15.0272961 0.0287424230 4.837388e-01 7.481853e-01 17 35641877 35641975 99 + 1.229 1.157 -0.253
ENSG00000006125 E036 13.7299589 0.0014617484 8.704884e-01 9.553921e-01 17 35650530 35650602 73 + 1.168 1.157 -0.038
ENSG00000006125 E037 14.1536067 0.0114566939 2.132090e-01 4.984272e-01 17 35650603 35650649 47 + 1.218 1.110 -0.387
ENSG00000006125 E038 27.4775010 0.0055474170 1.089656e-01 3.465592e-01 17 35650650 35650789 140 + 1.489 1.388 -0.348
ENSG00000006125 E039 0.0000000       17 35650914 35651005 92 +      
ENSG00000006125 E040 21.1113757 0.0006544667 3.840152e-01 6.701224e-01 17 35657599 35657791 193 + 1.362 1.308 -0.188
ENSG00000006125 E041 4.5201964 0.0031351214 5.140454e-01 7.708108e-01 17 35659764 35660120 357 + 0.702 0.782 0.323
ENSG00000006125 E042 5.5746358 0.0027734669 4.235430e-01 7.028080e-01 17 35670857 35670898 42 + 0.848 0.760 -0.349
ENSG00000006125 E043 21.0857528 0.0007634804 2.382011e-01 5.270968e-01 17 35671754 35671900 147 + 1.369 1.295 -0.259
ENSG00000006125 E044 35.0026389 0.0011609066 8.976880e-02 3.112381e-01 17 35674176 35674321 146 + 1.586 1.499 -0.295
ENSG00000006125 E045 25.8135860 0.0031726224 1.281397e-01 3.794382e-01 17 35682695 35682824 130 + 1.460 1.367 -0.322
ENSG00000006125 E046 0.1268540 0.0123015487 3.633223e-01   17 35707901 35707913 13 + 0.000 0.113 10.982
ENSG00000006125 E047 2.0203719 0.0069740936 7.221706e-06 2.577733e-04 17 35707914 35708000 87 + 0.080 0.737 4.465
ENSG00000006125 E048 1.3956697 0.0094914999 2.204148e-05 6.693611e-04 17 35708001 35708009 9 + 0.000 0.630 14.250
ENSG00000006125 E049 22.4400627 0.0007117865 2.733829e-01 5.671232e-01 17 35709224 35709308 85 + 1.334 1.404 0.243
ENSG00000006125 E050 21.2040427 0.0006154642 1.612650e-01 4.293770e-01 17 35710234 35710320 87 + 1.377 1.288 -0.308
ENSG00000006125 E051 33.2690864 0.0071848521 4.402890e-01 7.160554e-01 17 35717195 35717349 155 + 1.548 1.504 -0.151
ENSG00000006125 E052 308.5938862 0.0001761392 7.049393e-22 2.304254e-19 17 35723625 35726413 2789 + 2.422 2.559 0.456

Help

Please Click HERE to learn more details about the results from DEXseq.