ENSG00000021355

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380739 ENSG00000021355 No_inf pgKDN_inf SERPINB1 protein_coding protein_coding 12.80506 14.68653 13.42643 0.758804 1.146084 -0.1293261 10.1444978 13.313226 8.628786 0.4509665 0.5434496 -0.6250431 0.8036333 0.91745 0.648125 -0.269325 0.04505717 0.04505717 FALSE TRUE
ENST00000468511 ENSG00000021355 No_inf pgKDN_inf SERPINB1 protein_coding protein_coding_CDS_not_defined 12.80506 14.68653 13.42643 0.758804 1.146084 -0.1293261 0.3823859 0.000000 1.147158 0.0000000 1.1471577 6.8544416 0.0328500 0.00000 0.098550 0.098550 0.84241900 0.04505717 FALSE FALSE
ENST00000490094 ENSG00000021355 No_inf pgKDN_inf SERPINB1 protein_coding protein_coding_CDS_not_defined 12.80506 14.68653 13.42643 0.758804 1.146084 -0.1293261 2.1114057 1.245208 3.498643 1.2452078 1.3623945 1.4829868 0.1518250 0.07345 0.244275 0.170825 0.34261938 0.04505717 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000021355 E001 33.6165207 0.0011850571 0.01090126 0.08509896 6 2832332 2833511 1180 - 1.440 1.569 0.442
ENSG00000021355 E002 18.5699159 0.0007591111 0.32013884 0.61296453 6 2833512 2833699 188 - 1.235 1.302 0.234
ENSG00000021355 E003 39.6900768 0.0005458264 0.40423053 0.68703777 6 2833700 2834012 313 - 1.572 1.609 0.125
ENSG00000021355 E004 27.1158288 0.0005570755 0.38623519 0.67211481 6 2835856 2836023 168 - 1.464 1.417 -0.162
ENSG00000021355 E005 19.5742962 0.0069492849 0.23854780 0.52750776 6 2836108 2836250 143 - 1.350 1.266 -0.292
ENSG00000021355 E006 16.3481489 0.0008879811 0.10354941 0.33631420 6 2837882 2837999 118 - 1.293 1.180 -0.399
ENSG00000021355 E007 16.2546869 0.0008844224 0.32737875 0.61990820 6 2838549 2838686 138 - 1.265 1.196 -0.242
ENSG00000021355 E008 9.5081287 0.0014141642 0.97639334 0.99600724 6 2840419 2840485 67 - 1.007 1.010 0.010
ENSG00000021355 E009 8.7382494 0.0016370142 0.43233446 0.70977379 6 2840486 2840594 109 - 1.020 0.947 -0.270
ENSG00000021355 E010 0.1272623 0.0124096449 0.87070066   6 2841216 2841475 260 - 0.000 0.078 7.712
ENSG00000021355 E011 0.3638483 0.0164539757 0.34568646   6 2841597 2841811 215 - 0.207 0.078 -1.638
ENSG00000021355 E012 2.5913104 0.0066823588 0.92598485 0.97773821 6 2841812 2841959 148 - 0.537 0.550 0.062

Help

Please Click HERE to learn more details about the results from DEXseq.