ENSG00000037474

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264670 ENSG00000037474 No_inf pgKDN_inf NSUN2 protein_coding protein_coding 73.5926 57.26077 85.34326 2.120204 1.550212 0.5756473 53.291201 31.321824 68.486442 0.6765621 1.7454123 1.128400 0.70766667 0.55025 0.803425 0.253175 0.000126944 0.000126944 FALSE TRUE
ENST00000507888 ENSG00000037474 No_inf pgKDN_inf NSUN2 protein_coding retained_intron 73.5926 57.26077 85.34326 2.120204 1.550212 0.5756473 3.048696 4.437674 1.738485 0.5858286 0.9101576 -1.346945 0.04512500 0.07740 0.020000 -0.057400 0.204037151 0.000126944   FALSE
ENST00000513888 ENSG00000037474 No_inf pgKDN_inf NSUN2 protein_coding retained_intron 73.5926 57.26077 85.34326 2.120204 1.550212 0.5756473 9.539319 10.665057 7.884139 1.4793974 1.8962348 -0.435390 0.13629167 0.18925 0.091625 -0.097625 0.372661699 0.000126944 FALSE TRUE
ENST00000514127 ENSG00000037474 No_inf pgKDN_inf NSUN2 protein_coding nonsense_mediated_decay 73.5926 57.26077 85.34326 2.120204 1.550212 0.5756473 1.440347 4.321040 0.000000 2.5809273 0.0000000 -8.758570 0.02388333 0.07165 0.000000 -0.071650 0.411141620 0.000126944 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000037474 E001 0.4729834 1.607071e-02 1.282825e-01   5 6599239 6599239 1 - 0.247 0.000 -10.865
ENSG00000037474 E002 0.4729834 1.607071e-02 1.282825e-01   5 6599240 6599240 1 - 0.247 0.000 -13.421
ENSG00000037474 E003 41.7138176 9.458386e-03 5.060285e-01 7.647580e-01 5 6599241 6599399 159 - 1.604 1.646 0.142
ENSG00000037474 E004 94.7826650 1.833311e-04 4.057591e-01 6.884423e-01 5 6599400 6599568 169 - 1.961 1.988 0.089
ENSG00000037474 E005 214.0878181 9.059248e-05 7.459323e-02 2.784738e-01 5 6599569 6600029 461 - 2.308 2.344 0.120
ENSG00000037474 E006 32.3280954 6.546576e-04 4.041707e-02 1.950129e-01 5 6600030 6600232 203 - 1.467 1.576 0.374
ENSG00000037474 E007 19.9956735 7.209279e-04 2.599507e-04 5.183335e-03 5 6602461 6602500 40 - 1.202 1.441 0.837
ENSG00000037474 E008 2.4927220 1.029664e-01 7.733543e-03 6.756821e-02 5 6603869 6604137 269 - 0.291 0.756 2.298
ENSG00000037474 E009 81.7066212 1.948806e-04 2.227607e-02 1.357250e-01 5 6604138 6604276 139 - 1.876 1.953 0.258
ENSG00000037474 E010 66.3338635 2.608407e-04 5.436358e-01 7.905217e-01 5 6604605 6604685 81 - 1.809 1.833 0.079
ENSG00000037474 E011 6.0198070 5.299145e-02 6.469933e-02 2.564107e-01 5 6604686 6604800 115 - 0.716 0.976 1.010
ENSG00000037474 E012 16.5854227 5.178554e-03 3.963092e-09 3.027556e-07 5 6604801 6605272 472 - 0.999 1.451 1.601
ENSG00000037474 E013 75.3581820 5.370233e-04 8.298153e-01 9.383325e-01 5 6605273 6605408 136 - 1.876 1.869 -0.023
ENSG00000037474 E014 55.8499985 2.684140e-04 2.466677e-01 5.373059e-01 5 6606820 6606912 93 - 1.763 1.717 -0.157
ENSG00000037474 E015 1.3493452 1.031008e-02 2.712053e-01 5.649583e-01 5 6606913 6606926 14 - 0.291 0.459 0.976
ENSG00000037474 E016 83.6174837 2.505997e-04 2.950980e-02 1.613943e-01 5 6607200 6607384 185 - 1.945 1.873 -0.243
ENSG00000037474 E017 55.3534149 6.866951e-03 7.309910e-01 8.931581e-01 5 6609826 6609922 97 - 1.735 1.752 0.057
ENSG00000037474 E018 55.9776310 2.737104e-04 2.729436e-01 5.667350e-01 5 6610955 6611085 131 - 1.763 1.719 -0.149
ENSG00000037474 E019 33.1441868 1.591845e-03 8.992731e-02 3.114854e-01 5 6611725 6611798 74 - 1.558 1.465 -0.319
ENSG00000037474 E020 44.8245553 1.470848e-03 3.318593e-01 6.240027e-01 5 6616727 6616857 131 - 1.669 1.624 -0.154
ENSG00000037474 E021 32.4672107 4.949986e-04 3.983192e-01 6.823221e-01 5 6617950 6618024 75 - 1.532 1.488 -0.152
ENSG00000037474 E022 18.0469911 7.910791e-04 4.437291e-01 7.184357e-01 5 6620106 6620115 10 - 1.291 1.238 -0.186
ENSG00000037474 E023 52.3131143 3.809290e-04 1.640288e-01 4.331933e-01 5 6620116 6620298 183 - 1.740 1.681 -0.198
ENSG00000037474 E024 9.3873562 3.556179e-03 1.577040e-05 5.038867e-04 5 6620299 6621489 1191 - 0.803 1.205 1.491
ENSG00000037474 E025 1.3233792 9.814731e-03 4.600959e-01 7.315472e-01 5 6621603 6621744 142 - 0.403 0.288 -0.702
ENSG00000037474 E026 35.7307291 5.278556e-04 2.830445e-01 5.767025e-01 5 6622016 6622100 85 - 1.576 1.522 -0.185
ENSG00000037474 E027 35.8136478 3.162281e-03 1.826308e-03 2.378655e-02 5 6623214 6623285 72 - 1.618 1.442 -0.606
ENSG00000037474 E028 43.8632066 1.181403e-03 1.133375e-02 8.734989e-02 5 6625564 6625669 106 - 1.687 1.565 -0.414
ENSG00000037474 E029 32.2569385 4.177937e-04 2.701450e-02 1.527094e-01 5 6631873 6631977 105 - 1.556 1.437 -0.410
ENSG00000037474 E030 38.8306846 3.651577e-04 8.542464e-02 3.024348e-01 5 6632599 6632756 158 - 1.622 1.538 -0.287
ENSG00000037474 E031 24.3499560 6.206711e-04 3.615731e-01 6.510235e-01 5 6632884 6633291 408 - 1.416 1.361 -0.191

Help

Please Click HERE to learn more details about the results from DEXseq.