ENSG00000049860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261416 ENSG00000049860 No_inf pgKDN_inf HEXB protein_coding protein_coding 289.5178 386.0522 217.2051 16.3856 6.208217 -0.8297089 151.28681 175.74095 129.43545 4.841600 6.863286 -0.4411882 0.5378083 0.456425 0.595500 0.139075 0.004924816 0.004924816 FALSE TRUE
ENST00000513336 ENSG00000049860 No_inf pgKDN_inf HEXB protein_coding protein_coding 289.5178 386.0522 217.2051 16.3856 6.208217 -0.8297089 72.18500 121.09719 31.00866 10.289717 10.734167 -1.9650760 0.2330667 0.312025 0.144600 -0.167425 0.753732127 0.004924816 FALSE FALSE
MSTRG.23068.2 ENSG00000049860 No_inf pgKDN_inf HEXB protein_coding   289.5178 386.0522 217.2051 16.3856 6.208217 -0.8297089 21.15917 20.35302 18.88603 1.662396 2.358988 -0.1078685 0.0774000 0.053250 0.087625 0.034375 0.407080114 0.004924816 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000049860 E001 0.2541163 1.597895e-02 0.4860805714   5 74640023 74640558 536 + 0.000 0.138 11.682
ENSG00000049860 E002 2.3341456 6.149741e-03 0.3644965281 0.65318198 5 74685189 74685195 7 + 0.588 0.459 -0.612
ENSG00000049860 E003 5.5462512 3.413463e-03 0.4819263398 0.74692420 5 74685196 74685205 10 + 0.849 0.770 -0.312
ENSG00000049860 E004 17.4043791 7.946520e-04 0.5153669670 0.77146362 5 74685206 74685232 27 + 1.276 1.230 -0.162
ENSG00000049860 E005 245.6339332 1.042108e-04 0.0008396124 0.01310248 5 74685233 74685559 327 + 2.413 2.349 -0.216
ENSG00000049860 E006 189.7871140 1.487575e-04 0.0008102215 0.01274008 5 74689328 74689473 146 + 2.308 2.233 -0.249
ENSG00000049860 E007 0.5988574 1.891919e-01 0.0890128006 0.30959181 5 74689474 74689849 376 + 0.357 0.075 -2.764
ENSG00000049860 E008 0.3533378 1.571318e-02 0.0349315552   5 74693475 74693638 164 + 0.292 0.000 -13.904
ENSG00000049860 E009 106.2424073 1.673735e-04 0.0149320569 0.10474641 5 74693639 74693704 66 + 2.057 1.984 -0.243
ENSG00000049860 E010 104.5728098 1.528384e-04 0.0479224969 0.21537740 5 74696693 74696739 47 + 2.042 1.982 -0.199
ENSG00000049860 E011 167.7783092 1.067160e-04 0.0305505884 0.16445907 5 74696996 74697106 111 + 2.240 2.189 -0.171
ENSG00000049860 E012 0.6179948 1.985047e-02 0.8926803091 0.96441904 5 74702500 74702536 37 + 0.214 0.194 -0.179
ENSG00000049860 E013 152.6634501 3.812609e-04 0.4453204136 0.71976213 5 74705219 74705320 102 + 2.180 2.160 -0.065
ENSG00000049860 E014 5.2628763 9.633802e-03 0.1329433425 0.38715800 5 74705321 74706168 848 + 0.886 0.710 -0.697
ENSG00000049860 E015 102.1365980 1.715505e-03 0.1544620815 0.41987591 5 74713506 74713537 32 + 2.025 1.976 -0.163
ENSG00000049860 E016 155.8034964 1.453485e-04 0.1865133807 0.46449408 5 74713538 74713635 98 + 2.197 2.164 -0.109
ENSG00000049860 E017 124.7983135 1.458913e-04 0.7602245565 0.90617545 5 74715510 74715585 76 + 2.075 2.083 0.030
ENSG00000049860 E018 127.4223297 1.309962e-04 0.7873387497 0.91840578 5 74715586 74715645 60 + 2.094 2.087 -0.024
ENSG00000049860 E019 133.4842723 1.031214e-03 0.5757770883 0.81017465 5 74715646 74715690 45 + 2.098 2.115 0.057
ENSG00000049860 E020 127.9012007 3.031166e-04 0.5681423162 0.80571607 5 74716587 74716628 42 + 2.080 2.097 0.055
ENSG00000049860 E021 143.7346586 2.122035e-04 0.7961764318 0.92272771 5 74716629 74716673 45 + 2.145 2.139 -0.021
ENSG00000049860 E022 0.3731628 2.105133e-01 1.0000000000   5 74716674 74716829 156 + 0.120 0.139 0.236
ENSG00000049860 E023 180.7238048 3.958377e-04 0.4252994049 0.70437888 5 74718291 74718363 73 + 2.252 2.233 -0.063
ENSG00000049860 E024 261.1718193 8.293489e-04 0.0543744742 0.23219580 5 74718797 74718908 112 + 2.371 2.414 0.144
ENSG00000049860 E025 184.3813509 2.859333e-04 0.0124022842 0.09228819 5 74718909 74718971 63 + 2.209 2.269 0.201
ENSG00000049860 E026 6.3222612 2.206035e-03 0.5861299831 0.81641317 5 74719989 74720427 439 + 0.808 0.868 0.236
ENSG00000049860 E027 249.9713015 7.797612e-05 0.0010783568 0.01586473 5 74720428 74720487 60 + 2.337 2.402 0.217
ENSG00000049860 E028 205.4118842 9.816560e-05 0.0128043881 0.09433026 5 74720488 74720518 31 + 2.259 2.314 0.184
ENSG00000049860 E029 294.3035053 7.670175e-05 0.0044499218 0.04565039 5 74720643 74720747 105 + 2.417 2.469 0.173
ENSG00000049860 E030 1.8516878 7.435399e-03 0.8147904787 0.93235614 5 74720748 74720836 89 + 0.465 0.430 -0.179
ENSG00000049860 E031 0.8883830 1.208979e-02 0.0264604960 0.15074685 5 74721057 74721117 61 + 0.000 0.364 13.492
ENSG00000049860 E032 128.3221315 1.280176e-04 0.0539145872 0.23101751 5 74721118 74721317 200 + 2.057 2.111 0.182
ENSG00000049860 E033 0.0000000       5 74721318 74721436 119 +      
ENSG00000049860 E034 0.3723461 1.694771e-01 1.0000000000   5 74722299 74722468 170 + 0.120 0.138 0.235
ENSG00000049860 E035 0.1268540 1.228533e-02 1.0000000000   5 74722469 74722647 179 + 0.000 0.075 10.685

Help

Please Click HERE to learn more details about the results from DEXseq.