ENSG00000060237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000535572 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding protein_coding 55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 3.489952 1.295669 5.195964 0.7523126 2.151762 1.995376029 0.06628333 0.025850 0.103425 0.077575 6.711393e-01 9.036502e-13 FALSE TRUE
ENST00000540360 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding protein_coding_CDS_not_defined 55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 3.207618 0.240526 3.110490 0.2405260 2.351417 3.638740443 0.05225833 0.004675 0.051400 0.046725 7.776430e-01 9.036502e-13 FALSE TRUE
ENST00000540885 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding retained_intron 55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 3.531248 9.844375 0.000000 1.5026703 0.000000 -9.944620630 0.07153333 0.202275 0.000000 -0.202275 9.036502e-13 9.036502e-13 FALSE FALSE
ENST00000676347 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding protein_coding 55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 6.024078 4.018979 5.737484 1.3734521 3.447650 0.512516232 0.10815833 0.081100 0.103550 0.022450 8.671637e-01 9.036502e-13 FALSE TRUE
MSTRG.5827.13 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding   55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 3.998011 2.306044 5.246798 1.3344599 1.877232 1.182521530 0.07524167 0.046700 0.101425 0.054725 7.887390e-01 9.036502e-13 FALSE TRUE
MSTRG.5827.16 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding   55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 3.086163 4.228689 3.855176 2.1930310 2.322813 -0.133083807 0.06000833 0.088150 0.072225 -0.015925 8.478780e-01 9.036502e-13 FALSE TRUE
MSTRG.5827.27 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding   55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 18.108842 17.054842 17.040857 1.5131769 1.527966 -0.001182799 0.33125000 0.344525 0.317475 -0.027050 8.883994e-01 9.036502e-13 FALSE TRUE
MSTRG.5827.7 ENSG00000060237 No_inf pgKDN_inf WNK1 protein_coding   55.10464 49.2444 54.6635 1.588713 3.803557 0.150589 1.272220 0.000000 2.894236 0.0000000 1.060029 8.182014713 0.02288333 0.000000 0.051825 0.051825 3.125894e-02 9.036502e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000060237 E001 0.0000000       12 752579 752583 5 +      
ENSG00000060237 E002 0.1170040 0.0117310037 6.358602e-01   12 752584 752592 9 + 0.088 0.000 -11.071
ENSG00000060237 E003 0.2340080 0.2674981641 3.698840e-01   12 752593 752600 8 + 0.161 0.000 -13.523
ENSG00000060237 E004 0.2340080 0.2674981641 3.698840e-01   12 752601 752607 7 + 0.161 0.000 -13.523
ENSG00000060237 E005 0.7232908 0.0388600702 5.453889e-01 7.913429e-01 12 752608 752620 13 + 0.278 0.186 -0.745
ENSG00000060237 E006 6.2317407 0.0327750847 4.376633e-03 4.518556e-02 12 752621 752922 302 + 0.998 0.624 -1.481
ENSG00000060237 E007 4.2974419 0.0034258786 2.609591e-04 5.199323e-03 12 752923 753055 133 + 0.888 0.416 -2.067
ENSG00000060237 E008 10.0552298 0.0021693484 1.502824e-06 6.616595e-05 12 753056 753346 291 + 1.204 0.744 -1.724
ENSG00000060237 E009 57.7681946 0.0002556893 1.793615e-06 7.732838e-05 12 753347 754324 978 + 1.848 1.659 -0.637
ENSG00000060237 E010 20.1835192 0.0030340979 2.485119e-04 5.000324e-03 12 813642 813814 173 + 1.428 1.173 -0.890
ENSG00000060237 E011 23.5602428 0.0005978634 1.434857e-04 3.189926e-03 12 827042 827262 221 + 1.485 1.252 -0.812
ENSG00000060237 E012 0.1186381 0.0118554769 6.358480e-01   12 827263 827501 239 + 0.088 0.000 -13.392
ENSG00000060237 E013 0.3621491 0.0166872196 6.934248e-01   12 829925 830002 78 + 0.161 0.103 -0.745
ENSG00000060237 E014 17.3319001 0.0008624550 1.521718e-02 1.062150e-01 12 830003 830160 158 + 1.335 1.165 -0.596
ENSG00000060237 E015 0.0000000       12 851424 851782 359 +      
ENSG00000060237 E016 4.9416273 0.0031243886 1.380598e-02 9.905992e-02 12 857161 857162 2 + 0.888 0.596 -1.193
ENSG00000060237 E017 13.2610741 0.0010014952 1.763221e-04 3.775211e-03 12 857163 857249 87 + 1.272 0.968 -1.095
ENSG00000060237 E018 29.8844388 0.0004741021 1.104809e-04 2.583989e-03 12 859245 859464 220 + 1.577 1.365 -0.728
ENSG00000060237 E019 21.2152868 0.0009772616 9.804252e-03 7.927774e-02 12 861013 861123 111 + 1.417 1.252 -0.575
ENSG00000060237 E020 37.2840918 0.0004587536 6.992077e-03 6.299878e-02 12 861124 861343 220 + 1.639 1.509 -0.445
ENSG00000060237 E021 17.4580560 0.0007836550 3.076479e-02 1.650440e-01 12 862083 862173 91 + 1.330 1.181 -0.525
ENSG00000060237 E022 11.3161703 0.0017543742 4.628303e-01 7.329899e-01 12 862174 862234 61 + 1.117 1.058 -0.214
ENSG00000060237 E023 7.6385541 0.0098606623 1.653475e-01 4.350172e-01 12 862235 862270 36 + 0.998 0.854 -0.543
ENSG00000060237 E024 0.3707734 0.0166750517 4.844164e-01   12 865110 865364 255 + 0.088 0.186 1.255
ENSG00000060237 E025 2.1219824 0.0146159888 1.212208e-02 9.109631e-02 12 867866 868525 660 + 0.278 0.651 1.955
ENSG00000060237 E026 0.5081066 0.0159705428 3.001999e-02 1.630420e-01 12 868526 868567 42 + 0.000 0.316 14.686
ENSG00000060237 E027 3.3523032 0.0274913807 4.554280e-02 2.088162e-01 12 868568 869104 537 + 0.480 0.764 1.255
ENSG00000060237 E028 2.8398518 0.0204702304 1.698994e-01 4.420121e-01 12 869105 871264 2160 + 0.480 0.676 0.893
ENSG00000060237 E029 9.3481817 0.0368113763 2.411013e-01 5.304977e-01 12 871265 871348 84 + 1.070 0.942 -0.472
ENSG00000060237 E030 1.7120564 0.1147707106 8.635540e-01 9.527896e-01 12 877094 878014 921 + 0.410 0.458 0.255
ENSG00000060237 E031 1.1144584 0.0106706625 2.123983e-01 4.976031e-01 12 878015 878211 197 + 0.223 0.416 1.255
ENSG00000060237 E032 4.2618851 0.0243964279 5.388523e-01 7.873871e-01 12 878212 878214 3 + 0.756 0.676 -0.331
ENSG00000060237 E033 23.2243548 0.0006096332 7.722551e-01 9.122927e-01 12 878215 878361 147 + 1.373 1.394 0.072
ENSG00000060237 E034 0.7442524 0.5097167023 7.098210e-01 8.826571e-01 12 879573 880031 459 + 0.161 0.316 1.256
ENSG00000060237 E035 7.1520693 0.0019172983 1.168253e-01 3.606672e-01 12 880721 880999 279 + 0.978 0.821 -0.601
ENSG00000060237 E036 0.7345878 0.0147409055 8.378520e-01 9.419273e-01 12 881471 881691 221 + 0.223 0.256 0.255
ENSG00000060237 E037 14.2209826 0.0009867919 2.782157e-01 5.715332e-01 12 881692 881763 72 + 1.139 1.225 0.305
ENSG00000060237 E038 9.1718346 0.0018984160 7.044235e-01 8.798644e-01 12 881764 881789 26 + 0.988 1.026 0.139
ENSG00000060237 E039 26.4879365 0.0011225046 9.637174e-01 9.923479e-01 12 881911 882073 163 + 1.438 1.439 0.002
ENSG00000060237 E040 23.8800744 0.0020317430 7.845123e-03 6.822297e-02 12 882943 883059 117 + 1.466 1.301 -0.573
ENSG00000060237 E041 34.3675665 0.0030770966 4.159742e-02 1.982281e-01 12 883395 883568 174 + 1.597 1.487 -0.377
ENSG00000060237 E042 20.9169698 0.0024820681 1.982807e-01 4.797053e-01 12 883774 883831 58 + 1.378 1.295 -0.288
ENSG00000060237 E043 31.1687184 0.0004271935 2.490875e-01 5.399790e-01 12 884121 884243 123 + 1.534 1.475 -0.200
ENSG00000060237 E044 197.4281783 0.0007469894 7.572637e-06 2.685224e-04 12 884649 886084 1436 + 2.342 2.241 -0.336
ENSG00000060237 E045 20.0367201 0.0050112989 9.933032e-01 1.000000e+00 12 887221 887304 84 + 1.321 1.323 0.008
ENSG00000060237 E046 0.2545247 0.2673045178 2.458958e-01   12 887732 887793 62 + 0.000 0.186 12.969
ENSG00000060237 E047 22.2927046 0.0138912697 4.940870e-01 7.557344e-01 12 889140 889223 84 + 1.339 1.394 0.191
ENSG00000060237 E048 21.2110960 0.0011176353 5.822498e-01 8.139126e-01 12 890453 890510 58 + 1.361 1.329 -0.112
ENSG00000060237 E049 10.0058072 0.0051208593 9.081356e-01 9.707346e-01 12 890511 890513 3 + 1.045 1.037 -0.028
ENSG00000060237 E050 23.8183854 0.0008288462 9.528626e-02 3.213587e-01 12 894562 894635 74 + 1.438 1.340 -0.342
ENSG00000060237 E051 23.5369089 0.0033649581 7.474546e-01 9.002888e-01 12 896071 896124 54 + 1.397 1.380 -0.060
ENSG00000060237 E052 42.5043536 0.0068620656 3.435444e-01 6.347626e-01 12 896125 896283 159 + 1.661 1.611 -0.170
ENSG00000060237 E053 75.7177533 0.0002182350 3.180594e-01 6.108181e-01 12 896284 896622 339 + 1.899 1.868 -0.105
ENSG00000060237 E054 39.3699948 0.0003616180 5.120737e-01 7.691995e-01 12 896623 896732 110 + 1.619 1.591 -0.095
ENSG00000060237 E055 69.2784354 0.0002216445 1.109763e-01 3.496754e-01 12 897479 897681 203 + 1.816 1.877 0.204
ENSG00000060237 E056 0.0000000       12 900473 900475 3 +      
ENSG00000060237 E057 43.0471411 0.0003716003 1.769110e-02 1.169877e-01 12 900476 900596 121 + 1.587 1.698 0.378
ENSG00000060237 E058 30.7632712 0.0155502044 8.057071e-01 9.281010e-01 12 900597 900670 74 + 1.507 1.494 -0.044
ENSG00000060237 E059 2.1982246 0.0243165494 9.097674e-01 9.713623e-01 12 900671 901074 404 + 0.511 0.497 -0.067
ENSG00000060237 E060 1.0970838 0.0107202876 9.363751e-01 9.818623e-01 12 901561 901632 72 + 0.326 0.316 -0.067
ENSG00000060237 E061 0.1265070 0.0123261731 4.541294e-01   12 904453 904494 42 + 0.000 0.103 12.774
ENSG00000060237 E062 1.0062048 0.0147611892 1.483919e-02 1.043056e-01 12 907720 907846 127 + 0.088 0.458 3.062
ENSG00000060237 E063 60.4897864 0.0066465733 6.740592e-01 8.649499e-01 12 907847 908034 188 + 1.776 1.801 0.086
ENSG00000060237 E064 2.7019887 0.0053063268 4.173200e-01 6.970318e-01 12 908035 908201 167 + 0.511 0.624 0.518
ENSG00000060237 E065 769.5058617 0.0001920250 1.845894e-34 1.327419e-31 12 908475 911719 3245 + 2.827 2.944 0.389

Help

Please Click HERE to learn more details about the results from DEXseq.