ENSG00000065491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373491 ENSG00000065491 No_inf pgKDN_inf TBC1D22B protein_coding protein_coding 8.680001 8.551327 9.418485 0.6197863 0.07533452 0.1391915 6.9140104 3.786360 9.418485 1.470724 0.07533452 1.312409 0.78923333 0.43565 1 0.56435 8.213637e-06 8.213637e-06 FALSE TRUE
MSTRG.24625.2 ENSG00000065491 No_inf pgKDN_inf TBC1D22B protein_coding   8.680001 8.551327 9.418485 0.6197863 0.07533452 0.1391915 0.8817351 2.385009 0.000000 1.379233 0.00000000 -7.903887 0.11420833 0.30615 0 -0.30615 5.351066e-01 8.213637e-06 TRUE TRUE
MSTRG.24625.3 ENSG00000065491 No_inf pgKDN_inf TBC1D22B protein_coding   8.680001 8.551327 9.418485 0.6197863 0.07533452 0.1391915 0.8842550 2.379958 0.000000 0.898967 0.00000000 -7.900842 0.09655833 0.25820 0 -0.25820 2.737684e-02 8.213637e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000065491 E001 0.000000       6 37257772 37257789 18 +      
ENSG00000065491 E002 0.000000       6 37257790 37257825 36 +      
ENSG00000065491 E003 0.000000       6 37257826 37257973 148 +      
ENSG00000065491 E004 2.697585 0.007719304 0.824020282 0.9361565 6 37269594 37269650 57 + 0.540 0.595 0.248
ENSG00000065491 E005 14.264365 0.002939152 0.492373429 0.7545883 6 37279304 37279611 308 + 1.193 1.172 -0.074
ENSG00000065491 E006 6.911263 0.002184619 0.100273383 0.3307834 6 37282185 37282364 180 + 0.958 0.820 -0.530
ENSG00000065491 E007 4.969382 0.003127148 0.155815394 0.4218537 6 37282882 37282952 71 + 0.835 0.699 -0.545
ENSG00000065491 E008 8.270481 0.001878263 0.283433847 0.5771405 6 37284336 37284464 129 + 0.999 0.928 -0.266
ENSG00000065491 E009 5.685776 0.003700702 0.029729235 0.1621127 6 37287007 37287072 66 + 0.913 0.699 -0.845
ENSG00000065491 E010 5.840280 0.081628318 0.380926315 0.6673804 6 37291243 37291357 115 + 0.876 0.783 -0.363
ENSG00000065491 E011 8.037753 0.025448941 0.466512971 0.7351782 6 37312918 37313024 107 + 0.979 0.928 -0.193
ENSG00000065491 E012 6.605453 0.002704302 0.935875677 0.9816511 6 37313816 37313891 76 + 0.863 0.900 0.141
ENSG00000065491 E013 10.585405 0.002577277 0.242484996 0.5321457 6 37316703 37316830 128 + 1.095 1.025 -0.254
ENSG00000065491 E014 8.901867 0.001645838 0.514849034 0.7712011 6 37317111 37317206 96 + 1.009 0.979 -0.110
ENSG00000065491 E015 89.385332 0.012172278 0.002390392 0.0291389 6 37331044 37332970 1927 + 1.890 2.018 0.431

Help

Please Click HERE to learn more details about the results from DEXseq.