ENSG00000070950

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264926 ENSG00000070950 No_inf pgKDN_inf RAD18 protein_coding protein_coding 8.796105 15.16583 6.108456 12.36378 0.5363661 -1.310536 2.8112004 2.3681813 3.0686297 0.2807881 0.3876235 0.3724297 0.61020000 0.712725 0.498425 -0.214300 0.6485705895 0.0001096338 FALSE TRUE
ENST00000415439 ENSG00000070950 No_inf pgKDN_inf RAD18 protein_coding nonsense_mediated_decay 8.796105 15.16583 6.108456 12.36378 0.5363661 -1.310536 1.2747996 0.3447263 2.6848738 0.3447263 0.2333501 2.9254395 0.19638333 0.006600 0.455475 0.448875 0.0001096338 0.0001096338 TRUE TRUE
ENST00000473069 ENSG00000070950 No_inf pgKDN_inf RAD18 protein_coding retained_intron 8.796105 15.16583 6.108456 12.36378 0.5363661 -1.310536 0.5156797 0.0000000 0.3549527 0.0000000 0.3549527 5.1896375 0.08735833 0.000000 0.046100 0.046100 0.8374886827 0.0001096338 FALSE FALSE
MSTRG.19669.11 ENSG00000070950 No_inf pgKDN_inf RAD18 protein_coding   8.796105 15.16583 6.108456 12.36378 0.5363661 -1.310536 4.0932378 12.2797135 0.0000000 12.2797135 0.0000000 -10.2632356 0.07835000 0.235050 0.000000 -0.235050 0.8533887974 0.0001096338   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000070950 E001 0.0000000       3 8775402 8775664 263 -      
ENSG00000070950 E002 51.0750788 0.0003887154 0.006163496 0.05760174 3 8877075 8881263 4189 - 1.673 1.760 0.294
ENSG00000070950 E003 7.6997386 0.0021774518 0.451784337 0.72491189 3 8881264 8881419 156 - 0.905 0.973 0.258
ENSG00000070950 E004 5.1407694 0.0047995779 0.418517104 0.69814121 3 8881420 8881459 40 - 0.744 0.832 0.350
ENSG00000070950 E005 0.1265070 0.0122615740 0.378847639   3 8890109 8890388 280 - 0.000 0.111 10.762
ENSG00000070950 E006 5.7370530 0.0028680382 0.648204454 0.85144323 3 8890389 8890451 63 - 0.804 0.850 0.179
ENSG00000070950 E007 6.8042784 0.0024992224 0.737090806 0.89580999 3 8898894 8899047 154 - 0.905 0.868 -0.141
ENSG00000070950 E008 5.0423928 0.0029831096 0.015628230 0.10811328 3 8902380 8902520 141 - 0.882 0.591 -1.191
ENSG00000070950 E009 2.7656876 0.0057524359 0.125723715 0.37591656 3 8912312 8912372 61 - 0.655 0.438 -1.015
ENSG00000070950 E010 0.1187032 0.0117359580 0.758843821   3 8912373 8912469 97 - 0.082 0.000 -10.762
ENSG00000070950 E011 3.8511275 0.0114308235 0.123044068 0.37123846 3 8913644 8913720 77 - 0.760 0.557 -0.866
ENSG00000070950 E012 8.2070016 0.0415500173 0.109638376 0.34753078 3 8935871 8936055 185 - 1.030 0.850 -0.675
ENSG00000070950 E013 4.0018278 0.0038577084 0.544037617 0.79063712 3 8939554 8939653 100 - 0.728 0.651 -0.320
ENSG00000070950 E014 1.4788710 0.0088834399 0.244498108 0.53478631 3 8941467 8941512 46 - 0.308 0.481 0.973
ENSG00000070950 E015 0.9885161 0.0139950991 0.235938458 0.52528862 3 8941513 8941530 18 - 0.210 0.389 1.224
ENSG00000070950 E016 1.4948911 0.0091989936 0.019422868 0.12457521 3 8941531 8941550 20 - 0.210 0.557 2.072
ENSG00000070950 E017 7.8202006 0.0145507281 0.410472591 0.69230185 3 8941551 8941795 245 - 0.905 0.987 0.307
ENSG00000070950 E018 1.9245380 0.1119662239 0.218616062 0.50522061 3 8941796 8941804 9 - 0.542 0.334 -1.097
ENSG00000070950 E019 0.1176306 0.0118815904 0.758370283   3 8946952 8947219 268 - 0.082 0.000 -10.762
ENSG00000070950 E020 2.0591958 0.0084060192 0.605190304 0.82795155 3 8947220 8947242 23 - 0.515 0.438 -0.387
ENSG00000070950 E021 2.6406290 0.0059116250 0.065379086 0.25749819 3 8947243 8947290 48 - 0.655 0.389 -1.278
ENSG00000070950 E022 2.7860160 0.0091247859 0.517072056 0.77262680 3 8948509 8948554 46 - 0.613 0.521 -0.420
ENSG00000070950 E023 1.4596079 0.0301471689 0.988948077 1.00000000 3 8948555 8948570 16 - 0.389 0.389 0.002
ENSG00000070950 E024 0.1271363 0.0124665271 0.378417393   3 8958916 8958919 4 - 0.000 0.111 10.761
ENSG00000070950 E025 2.4051938 0.0067661034 0.124699411 0.37436825 3 8958920 8959001 82 - 0.613 0.389 -1.098
ENSG00000070950 E026 1.8070303 0.0078357385 0.235727594 0.52504893 3 8963335 8963593 259 - 0.515 0.334 -0.972
ENSG00000070950 E027 0.0000000       3 8963676 8963773 98 -      

Help

Please Click HERE to learn more details about the results from DEXseq.