ENSG00000072518

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377810 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding protein_coding 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 1.7702356 1.435529 0.3259205 0.6909646 0.1913346 -2.1054056 0.08248333 0.067900 0.015425 -0.052475 0.63714643 0.02462455 FALSE  
ENST00000402010 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding protein_coding 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 1.5337967 1.766596 2.2150527 1.0302680 1.3376725 0.3247239 0.07110833 0.081975 0.104975 0.023000 1.00000000 0.02462455 FALSE  
ENST00000408948 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding protein_coding 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 7.7348036 8.950655 7.1473295 0.6193928 2.4786128 -0.3241828 0.35887500 0.416525 0.335075 -0.081450 0.84954017 0.02462455 FALSE  
ENST00000502399 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding protein_coding 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 0.4460188 1.338056 0.0000000 0.7891604 0.0000000 -7.0747370 0.02130833 0.063925 0.000000 -0.063925 0.50584665 0.02462455 FALSE  
ENST00000508192 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding protein_coding 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 3.7474594 3.724470 4.9501302 1.5703354 2.0603735 0.4094744 0.17890833 0.171625 0.242125 0.070500 0.92729897 0.02462455 FALSE  
ENST00000513765 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding protein_coding 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 1.9431908 0.000000 3.4736672 0.0000000 2.1584097 8.4444630 0.09435833 0.000000 0.170150 0.170150 0.48433542 0.02462455 FALSE  
ENST00000677303 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding nonsense_mediated_decay 21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 1.2089477 2.470636 0.3226972 0.3931161 0.0931043 -2.8984288 0.05634167 0.114250 0.015675 -0.098575 0.02462455 0.02462455 TRUE  
MSTRG.4891.6 ENSG00000072518 No_inf pgKDN_inf MARK2 protein_coding   21.2909 21.51123 20.93587 0.8755331 0.4003832 -0.03909478 1.2180600 0.000000 1.8472691 0.0000000 1.8472691 7.5370390 0.05755000 0.000000 0.085125 0.085125 0.84231814 0.02462455 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000072518 E001 1.1340964 0.0107128753 1.933223e-02 1.242175e-01 11 63838928 63839004 77 + 0.098 0.460 2.894
ENSG00000072518 E002 1.3774788 0.0241441769 4.561031e-02 2.090014e-01 11 63839005 63839092 88 + 0.178 0.495 2.063
ENSG00000072518 E003 1.1332145 0.0139757694 1.969449e-02 1.257197e-01 11 63839093 63839109 17 + 0.098 0.460 2.894
ENSG00000072518 E004 1.7402603 0.0105796263 1.473452e-01 4.086658e-01 11 63839110 63839137 28 + 0.304 0.526 1.215
ENSG00000072518 E005 8.5373640 0.0048208326 2.035899e-01 4.861891e-01 11 63839138 63839294 157 + 1.038 0.920 -0.438
ENSG00000072518 E006 9.2075979 0.0015291765 8.340724e-01 9.402797e-01 11 63839295 63839429 135 + 0.995 1.019 0.086
ENSG00000072518 E007 4.2091841 0.2122967803 3.112840e-01 6.044786e-01 11 63839430 63839463 34 + 0.634 0.775 0.582
ENSG00000072518 E008 8.5890030 0.0039079319 9.105254e-01 9.716700e-01 11 63839464 63839560 97 + 0.984 0.977 -0.024
ENSG00000072518 E009 0.1271363 0.0122910438 5.848955e-01   11 63849963 63850029 67 + 0.000 0.092 11.168
ENSG00000072518 E010 0.1271363 0.0122910438 5.848955e-01   11 63868470 63868909 440 + 0.000 0.092 11.168
ENSG00000072518 E011 0.0000000       11 63869276 63869372 97 +      
ENSG00000072518 E012 0.0000000       11 63880148 63880228 81 +      
ENSG00000072518 E013 0.3611417 0.0165004706 5.326468e-01   11 63888547 63888695 149 + 0.178 0.092 -1.106
ENSG00000072518 E014 1.0978745 0.0133410676 6.506791e-01 8.529297e-01 11 63888696 63888964 269 + 0.356 0.289 -0.428
ENSG00000072518 E015 0.1187032 0.0118400025 4.948163e-01   11 63890222 63890295 74 + 0.098 0.000 -12.046
ENSG00000072518 E016 5.6243981 0.0025127509 5.638926e-01 8.031314e-01 11 63895159 63895185 27 + 0.851 0.792 -0.232
ENSG00000072518 E017 9.0495584 0.0187662280 6.005459e-01 8.250928e-01 11 63895186 63895281 96 + 1.027 0.977 -0.184
ENSG00000072518 E018 8.9501419 0.0035166651 9.934136e-01 1.000000e+00 11 63895282 63895338 57 + 0.995 0.998 0.012
ENSG00000072518 E019 12.6202486 0.0012116613 8.931396e-01 9.645186e-01 11 63895580 63895633 54 + 1.137 1.130 -0.022
ENSG00000072518 E020 0.0000000       11 63895880 63895949 70 +      
ENSG00000072518 E021 0.6344876 0.0147687985 2.590380e-02 1.488013e-01 11 63895950 63898086 2137 + 0.000 0.338 13.340
ENSG00000072518 E022 0.1271363 0.0122910438 5.848955e-01   11 63898087 63898231 145 + 0.000 0.092 11.168
ENSG00000072518 E023 12.7378730 0.0030335673 8.160859e-01 9.327931e-01 11 63898232 63898280 49 + 1.145 1.130 -0.051
ENSG00000072518 E024 1.3550709 0.1485966188 9.063964e-01 9.701607e-01 11 63898281 63898607 327 + 0.356 0.383 0.156
ENSG00000072518 E025 12.4440963 0.0021247698 1.624302e-01 4.308306e-01 11 63898608 63898659 52 + 1.182 1.074 -0.390
ENSG00000072518 E026 8.0226248 0.0019272808 4.001751e-02 1.939547e-01 11 63898660 63898673 14 + 1.048 0.853 -0.728
ENSG00000072518 E027 0.3611417 0.0165004706 5.326468e-01   11 63898674 63898762 89 + 0.178 0.092 -1.106
ENSG00000072518 E028 14.9525504 0.0021181957 4.288072e-03 4.459191e-02 11 63898763 63898833 71 + 1.302 1.091 -0.750
ENSG00000072518 E029 0.0000000       11 63898834 63899051 218 +      
ENSG00000072518 E030 11.0386534 0.0013749103 2.514564e-03 3.024543e-02 11 63899052 63899108 57 + 1.197 0.944 -0.920
ENSG00000072518 E031 0.3727544 0.0167277576 6.369879e-01   11 63899109 63899873 765 + 0.098 0.168 0.894
ENSG00000072518 E032 27.8030797 0.0014767081 2.788136e-02 1.558972e-01 11 63899874 63900110 237 + 1.518 1.399 -0.411
ENSG00000072518 E033 0.5086713 0.1734069966 8.354731e-02 2.979792e-01 11 63900111 63900558 448 + 0.000 0.289 12.651
ENSG00000072518 E034 20.8038011 0.0009072430 3.914088e-01 6.765670e-01 11 63900559 63900678 120 + 1.364 1.313 -0.174
ENSG00000072518 E035 18.9273440 0.0210503649 6.250975e-01 8.386201e-01 11 63900780 63900879 100 + 1.274 1.318 0.156
ENSG00000072518 E036 21.4832294 0.0034027100 1.232867e-01 3.717127e-01 11 63900957 63901069 113 + 1.400 1.303 -0.336
ENSG00000072518 E037 23.9317556 0.0006514788 7.334265e-01 8.940403e-01 11 63902198 63902330 133 + 1.382 1.407 0.086
ENSG00000072518 E038 1.2080170 0.0108632462 1.623785e-01 4.308263e-01 11 63902601 63902603 3 + 0.444 0.232 -1.329
ENSG00000072518 E039 16.6482996 0.0008412381 5.060766e-01 7.647940e-01 11 63902604 63902686 83 + 1.268 1.225 -0.149
ENSG00000072518 E040 18.8883508 0.0007497282 9.663053e-01 9.931250e-01 11 63902687 63902782 96 + 1.297 1.298 0.006
ENSG00000072518 E041 14.8007711 0.0009810556 4.605042e-01 7.319245e-01 11 63903061 63903132 72 + 1.224 1.174 -0.178
ENSG00000072518 E042 10.3345729 0.0038954838 4.984571e-02 2.202709e-01 11 63903133 63903158 26 + 1.137 0.966 -0.621
ENSG00000072518 E043 0.1268540 0.0123395052 5.848056e-01   11 63903159 63903403 245 + 0.000 0.092 11.168
ENSG00000072518 E044 6.4518218 0.0233373483 2.725172e-01 5.662202e-01 11 63903986 63904097 112 + 0.935 0.808 -0.489
ENSG00000072518 E045 3.3242983 0.0151229475 4.752297e-01 7.418262e-01 11 63904098 63904147 50 + 0.579 0.679 0.434
ENSG00000072518 E046 0.2533610 0.0160632024 2.724787e-01   11 63904148 63904354 207 + 0.000 0.168 12.110
ENSG00000072518 E047 33.0572411 0.0195064390 5.703762e-01 8.069872e-01 11 63904786 63905043 258 + 1.551 1.513 -0.128
ENSG00000072518 E048 2.5982051 0.2371670887 5.285562e-01 7.802047e-01 11 63906088 63906114 27 + 0.482 0.609 0.591
ENSG00000072518 E049 13.5812608 0.0085100787 1.022720e-12 1.338820e-10 11 63906115 63907567 1453 + 0.659 1.365 2.641
ENSG00000072518 E050 17.0893615 0.0018573296 5.497140e-01 7.944126e-01 11 63908260 63908304 45 + 1.230 1.277 0.164
ENSG00000072518 E051 226.1834105 0.0002083235 5.153358e-03 5.071919e-02 11 63908877 63911020 2144 + 2.327 2.378 0.170

Help

Please Click HERE to learn more details about the results from DEXseq.