ENSG00000076928

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354532 ENSG00000076928 No_inf pgKDN_inf ARHGEF1 protein_coding protein_coding 146.543 261.2974 89.59692 15.67364 10.94584 -1.544066 39.267678 44.549244 40.214650 1.9637086 1.7096423 -0.1476449 0.33538333 0.171650 0.461225 0.289575 5.668672e-09 5.668672e-09 FALSE TRUE
ENST00000595723 ENSG00000076928 No_inf pgKDN_inf ARHGEF1 protein_coding protein_coding 146.543 261.2974 89.59692 15.67364 10.94584 -1.544066 12.329541 21.433546 6.443786 8.2310403 6.4437860 -1.7323259 0.07752500 0.077475 0.053175 -0.024300 5.032629e-01 5.668672e-09 FALSE TRUE
ENST00000595897 ENSG00000076928 No_inf pgKDN_inf ARHGEF1 protein_coding retained_intron 146.543 261.2974 89.59692 15.67364 10.94584 -1.544066 8.074003 18.670210 2.015844 2.0155467 0.1999059 -3.2049154 0.04591667 0.073625 0.023575 -0.050050 3.547053e-02 5.668672e-09 TRUE TRUE
ENST00000617585 ENSG00000076928 No_inf pgKDN_inf ARHGEF1 protein_coding retained_intron 146.543 261.2974 89.59692 15.67364 10.94584 -1.544066 19.448046 40.571154 7.277859 3.3145669 0.4944214 -2.4772429 0.11995833 0.156475 0.085125 -0.071350 1.292502e-01 5.668672e-09 FALSE FALSE
MSTRG.15225.1 ENSG00000076928 No_inf pgKDN_inf ARHGEF1 protein_coding   146.543 261.2974 89.59692 15.67364 10.94584 -1.544066 12.277899 26.238821 3.466114 0.7703186 0.3758973 -2.9167054 0.07421667 0.101200 0.040850 -0.060350 2.520710e-02 5.668672e-09 FALSE TRUE
MSTRG.15225.9 ENSG00000076928 No_inf pgKDN_inf ARHGEF1 protein_coding   146.543 261.2974 89.59692 15.67364 10.94584 -1.544066 3.641329 2.547322 6.239867 2.5473215 2.2147930 1.2891920 0.03833333 0.011600 0.079000 0.067400 1.377526e-01 5.668672e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000076928 E001 0.1272623 0.0123623891 1.000000e+00   19 41883173 41883182 10 + 0.000 0.063 9.627
ENSG00000076928 E002 0.1272623 0.0123623891 1.000000e+00   19 41883183 41883183 1 + 0.000 0.063 12.162
ENSG00000076928 E003 0.3646036 0.0165821716 1.814716e-01   19 41883184 41883199 16 + 0.246 0.063 -2.279
ENSG00000076928 E004 0.9728741 0.0166870113 5.462300e-02 2.327963e-01 19 41883200 41883203 4 + 0.463 0.168 -2.016
ENSG00000076928 E005 1.3527421 0.0102000044 2.592015e-01 5.517752e-01 19 41883204 41883204 1 + 0.463 0.288 -1.016
ENSG00000076928 E006 10.6050879 0.0016369758 2.431334e-02 1.429406e-01 19 41883205 41883223 19 + 1.157 0.955 -0.736
ENSG00000076928 E007 11.2301312 0.0013042553 3.582434e-02 1.815931e-01 19 41883224 41883224 1 + 1.168 0.984 -0.668
ENSG00000076928 E008 21.8554801 0.0006611884 5.551913e-03 5.342317e-02 19 41883225 41883289 65 + 1.436 1.255 -0.633
ENSG00000076928 E009 0.4784926 0.0388776221 6.402782e-02   19 41884370 41884373 4 + 0.331 0.063 -2.864
ENSG00000076928 E010 0.5971307 0.0155021799 1.998052e-02 1.269403e-01 19 41884374 41884396 23 + 0.402 0.063 -3.279
ENSG00000076928 E011 0.8602797 0.0192616113 4.475216e-01 7.216513e-01 19 41884397 41884424 28 + 0.331 0.212 -0.864
ENSG00000076928 E012 0.8697828 0.0131702964 9.737695e-01 9.953432e-01 19 41884425 41884447 23 + 0.246 0.252 0.043
ENSG00000076928 E013 1.2336612 0.0106200502 4.689963e-01 7.370187e-01 19 41884448 41884493 46 + 0.402 0.288 -0.694
ENSG00000076928 E014 24.4555810 0.0022849762 7.809696e-03 6.802457e-02 19 41888064 41888106 43 + 1.477 1.305 -0.596
ENSG00000076928 E015 38.5779573 0.0004634689 2.536883e-03 3.045276e-02 19 41888192 41888278 87 + 1.655 1.502 -0.522
ENSG00000076928 E016 53.6437206 0.0002635771 1.782880e-04 3.806623e-03 19 41888752 41888865 114 + 1.800 1.639 -0.546
ENSG00000076928 E017 15.7854803 0.0008957994 5.176055e-03 5.087759e-02 19 41888866 41890776 1911 + 0.990 1.235 0.884
ENSG00000076928 E018 41.5195814 0.0019839401 6.443724e-04 1.062151e-02 19 41892025 41892123 99 + 1.701 1.525 -0.597
ENSG00000076928 E019 3.9164333 0.0065467064 1.756529e-03 2.309523e-02 19 41892124 41892330 207 + 0.246 0.745 2.579
ENSG00000076928 E020 28.8601074 0.0011692121 7.018825e-02 2.680997e-01 19 41892331 41892373 43 + 1.504 1.396 -0.371
ENSG00000076928 E021 0.2545247 0.2927053358 8.607650e-01   19 41892374 41892528 155 + 0.000 0.119 12.277
ENSG00000076928 E022 26.3077230 0.0052117294 4.001003e-01 6.836253e-01 19 41892603 41892633 31 + 1.430 1.373 -0.197
ENSG00000076928 E023 75.3367176 0.0042041361 4.605056e-03 4.671226e-02 19 41892634 41892849 216 + 1.923 1.796 -0.426
ENSG00000076928 E024 0.2543986 0.0160550512 7.649822e-01   19 41893190 41893273 84 + 0.000 0.119 13.122
ENSG00000076928 E025 28.8765365 0.0062667033 5.314342e-03 5.179852e-02 19 41893274 41893303 30 + 1.553 1.370 -0.627
ENSG00000076928 E026 53.7201276 0.0012709033 6.584554e-03 6.036569e-02 19 41894207 41894291 85 + 1.776 1.653 -0.417
ENSG00000076928 E027 36.2577100 0.0040262996 2.701023e-02 1.527027e-01 19 41894292 41894306 15 + 1.613 1.485 -0.439
ENSG00000076928 E028 45.2885989 0.0034576233 1.108359e-02 8.596168e-02 19 41894451 41894486 36 + 1.710 1.577 -0.453
ENSG00000076928 E029 54.9023347 0.0014447935 4.209149e-02 1.996449e-01 19 41894487 41894547 61 + 1.765 1.672 -0.313
ENSG00000076928 E030 36.4295516 0.0075808007 9.641046e-01 9.924265e-01 19 41894626 41894661 36 + 1.529 1.525 -0.012
ENSG00000076928 E031 37.3714274 0.0031566012 4.051355e-01 6.878848e-01 19 41895349 41895378 30 + 1.571 1.523 -0.163
ENSG00000076928 E032 71.9091356 0.0002610253 3.168101e-02 1.681279e-01 19 41895379 41895486 108 + 1.873 1.791 -0.275
ENSG00000076928 E033 63.6690692 0.0008009964 1.526671e-02 1.064092e-01 19 41896377 41896482 106 + 1.833 1.733 -0.338
ENSG00000076928 E034 51.5968336 0.0012501233 2.292182e-15 4.000858e-13 19 41896483 41896878 396 + 1.302 1.760 1.569
ENSG00000076928 E035 14.4144724 0.0009898300 3.791655e-03 4.093196e-02 19 41897315 41897326 12 + 0.936 1.202 0.969
ENSG00000076928 E036 40.6070293 0.0003293973 4.181713e-18 9.679678e-16 19 41897327 41897674 348 + 1.095 1.671 2.004
ENSG00000076928 E037 31.9711581 0.0004533648 9.528702e-20 2.519221e-17 19 41897675 41897810 136 + 0.851 1.582 2.610
ENSG00000076928 E038 36.9419893 0.0006316691 1.389296e-16 2.775195e-14 19 41897811 41897945 135 + 1.053 1.631 2.021
ENSG00000076928 E039 21.2164054 0.0006378963 3.145877e-05 8.977558e-04 19 41897946 41897982 37 + 1.038 1.370 1.180
ENSG00000076928 E040 50.9193943 0.0002814722 1.458302e-08 1.005781e-06 19 41897983 41898113 131 + 1.436 1.732 1.009
ENSG00000076928 E041 71.5581892 0.0002178532 8.695552e-27 4.078138e-24 19 41898114 41898423 310 + 1.378 1.907 1.803
ENSG00000076928 E042 19.2632763 0.0053505270 1.293296e-06 5.827288e-05 19 41898424 41898441 18 + 0.896 1.347 1.628
ENSG00000076928 E043 115.8795035 0.0001683052 2.003280e-03 2.559093e-02 19 41898442 41898587 146 + 2.085 1.992 -0.309
ENSG00000076928 E044 0.3812526 0.0158716491 4.252462e-01   19 41900836 41900933 98 + 0.000 0.168 13.690
ENSG00000076928 E045 109.5056901 0.0001494351 2.125573e-01 4.977234e-01 19 41901887 41902026 140 + 2.023 1.985 -0.129
ENSG00000076928 E046 32.6966977 0.0004417174 9.660258e-01 9.930363e-01 19 41902027 41902033 7 + 1.482 1.480 -0.007
ENSG00000076928 E047 87.9397962 0.0001723448 6.693124e-01 8.624700e-01 19 41902274 41902356 83 + 1.890 1.906 0.053
ENSG00000076928 E048 128.6022342 0.0001449444 6.674373e-01 8.615299e-01 19 41902533 41902658 126 + 2.074 2.062 -0.040
ENSG00000076928 E049 49.9102449 0.0002854989 4.464256e-01 7.208190e-01 19 41902784 41902797 14 + 1.633 1.670 0.124
ENSG00000076928 E050 103.5815238 0.0009551697 8.416394e-01 9.431903e-01 19 41902798 41902898 101 + 1.966 1.974 0.026
ENSG00000076928 E051 109.3070886 0.0001713507 3.971201e-01 6.814558e-01 19 41903307 41903407 101 + 2.014 1.987 -0.088
ENSG00000076928 E052 3.5209199 0.0573840662 1.100384e-01 3.481018e-01 19 41903656 41903706 51 + 0.402 0.679 1.306
ENSG00000076928 E053 98.4511867 0.0001807795 2.195870e-01 5.062430e-01 19 41903707 41903784 78 + 1.979 1.938 -0.135
ENSG00000076928 E054 95.7984006 0.0056418519 2.448166e-01 5.352224e-01 19 41904035 41904110 76 + 1.977 1.922 -0.183
ENSG00000076928 E055 142.3310114 0.0001564169 3.487728e-02 1.786223e-01 19 41904216 41904383 168 + 2.149 2.092 -0.191
ENSG00000076928 E056 100.3251453 0.0002284102 3.118610e-01 6.051852e-01 19 41904949 41905036 88 + 1.933 1.967 0.116
ENSG00000076928 E057 107.7309538 0.0001541615 1.255642e-01 3.755667e-01 19 41905175 41905261 87 + 1.952 2.002 0.169
ENSG00000076928 E058 4.1195056 0.0036320431 5.317298e-01 7.822781e-01 19 41905513 41905589 77 + 0.608 0.693 0.365
ENSG00000076928 E059 5.3852385 0.0096960292 1.263714e-01 3.768691e-01 19 41905590 41905759 170 + 0.608 0.813 0.850
ENSG00000076928 E060 72.3544885 0.0002376743 8.347910e-01 9.405196e-01 19 41905760 41905799 40 + 1.823 1.816 -0.026
ENSG00000076928 E061 61.0995663 0.0002700581 6.079719e-01 8.292158e-01 19 41905800 41905827 28 + 1.729 1.752 0.076
ENSG00000076928 E062 92.0394876 0.0013124893 3.746556e-01 6.622751e-01 19 41905939 41906025 87 + 1.944 1.912 -0.109
ENSG00000076928 E063 25.6277587 0.0005294595 5.694567e-07 2.802288e-05 19 41906026 41906335 310 + 1.081 1.455 1.314
ENSG00000076928 E064 75.7844973 0.0001909068 5.259767e-01 7.785287e-01 19 41906457 41906575 119 + 1.855 1.831 -0.079
ENSG00000076928 E065 46.9834469 0.0014492523 8.439834e-01 9.441949e-01 19 41906576 41906620 45 + 1.641 1.631 -0.031
ENSG00000076928 E066 2.3866126 0.0062670042 1.780082e-01 4.528118e-01 19 41906621 41906702 82 + 0.331 0.546 1.136
ENSG00000076928 E067 88.8167826 0.0001787538 6.945690e-02 2.663721e-01 19 41906703 41906803 101 + 1.950 1.888 -0.209
ENSG00000076928 E068 15.7615993 0.0095789617 3.140885e-02 1.672265e-01 19 41906804 41907104 301 + 1.023 1.227 0.735
ENSG00000076928 E069 151.5287203 0.0001402327 2.225456e-01 5.099319e-01 19 41907105 41907454 350 + 2.158 2.126 -0.107
ENSG00000076928 E070 0.0000000       19 41923092 41923093 2 +      
ENSG00000076928 E071 0.1272623 0.0123623891 1.000000e+00   19 41923094 41923211 118 + 0.000 0.063 12.162
ENSG00000076928 E072 0.2541163 0.0160502057 7.650514e-01   19 41923212 41923233 22 + 0.000 0.119 13.122
ENSG00000076928 E073 0.2536433 0.0160287154 7.650535e-01   19 41928590 41928722 133 + 0.000 0.119 13.122
ENSG00000076928 E074 0.0000000       19 41928820 41928830 11 +      
ENSG00000076928 E075 0.0000000       19 41928831 41928853 23 +      
ENSG00000076928 E076 0.3802150 0.0289364204 4.286235e-01   19 41928854 41928986 133 + 0.000 0.168 13.619
ENSG00000076928 E077 0.8879132 0.2296283840 1.376763e-01 3.949990e-01 19 41929655 41930150 496 + 0.000 0.322 14.146

Help

Please Click HERE to learn more details about the results from DEXseq.