ENSG00000077463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337491 ENSG00000077463 No_inf pgKDN_inf SIRT6 protein_coding protein_coding 47.70257 46.43465 44.60246 1.694122 1.85103 -0.05806568 21.829880 16.404235 24.706352 0.4238980 0.8402736 0.5905183 0.4600250 0.35530 0.554475 0.199175 0.01036051 0.01036051 FALSE TRUE
ENST00000594341 ENSG00000077463 No_inf pgKDN_inf SIRT6 protein_coding retained_intron 47.70257 46.43465 44.60246 1.694122 1.85103 -0.05806568 10.268678 15.026787 5.847525 2.1251736 2.2141892 -1.3601331 0.2130333 0.32115 0.129550 -0.191600 0.42482006 0.01036051 FALSE FALSE
ENST00000599394 ENSG00000077463 No_inf pgKDN_inf SIRT6 protein_coding retained_intron 47.70257 46.43465 44.60246 1.694122 1.85103 -0.05806568 6.887565 7.819893 4.015881 0.7021259 0.9943622 -0.9596879 0.1421667 0.16850 0.088125 -0.080375 0.40067863 0.01036051 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000077463 E001 0.0000000       19 4174109 4174109 1 -      
ENSG00000077463 E002 1.9601886 0.0081086568 7.559163e-01 0.9038399940 19 4174110 4174140 31 - 0.448 0.495 0.238
ENSG00000077463 E003 53.8704010 0.0002899651 7.787889e-01 0.9149983786 19 4174141 4174619 479 - 1.732 1.746 0.047
ENSG00000077463 E004 7.4551490 0.0057707354 8.272729e-01 0.9374821804 19 4174620 4174635 16 - 0.915 0.940 0.096
ENSG00000077463 E005 12.9802794 0.0036812835 5.511647e-01 0.7950605086 19 4174636 4174703 68 - 1.120 1.171 0.183
ENSG00000077463 E006 24.8161646 0.0128791162 8.413100e-01 0.9430542838 19 4174704 4174860 157 - 1.404 1.419 0.052
ENSG00000077463 E007 11.4942452 0.0014162614 1.401820e-02 0.1001666119 19 4174861 4174877 17 - 1.182 0.978 -0.740
ENSG00000077463 E008 20.6844632 0.0014444954 1.469909e-01 0.4080608798 19 4174878 4174946 69 - 1.376 1.286 -0.312
ENSG00000077463 E009 1.3708408 0.0101188629 7.702762e-02 0.2839228551 19 4174947 4175027 81 - 0.224 0.495 1.653
ENSG00000077463 E010 21.2392960 0.0168661920 7.602539e-01 0.9061754529 19 4175028 4175111 84 - 1.355 1.337 -0.062
ENSG00000077463 E011 15.4522405 0.0059797722 3.494033e-01 0.6398233444 19 4175112 4175151 40 - 1.247 1.179 -0.244
ENSG00000077463 E012 8.9561891 0.0524963325 1.784315e-03 0.0233915356 19 4175152 4175571 420 - 0.759 1.163 1.517
ENSG00000077463 E013 3.5989332 0.0043169205 1.380170e-02 0.0990526587 19 4175572 4175679 108 - 0.481 0.800 1.390
ENSG00000077463 E014 23.5174588 0.0094875585 6.252554e-01 0.8386830770 19 4175680 4175760 81 - 1.404 1.373 -0.108
ENSG00000077463 E015 1.9859404 0.0072076863 7.049074e-02 0.2687957688 19 4175761 4175790 30 - 0.328 0.594 1.375
ENSG00000077463 E016 2.1217009 0.0066557292 1.143250e-02 0.0878839926 19 4175791 4175841 51 - 0.279 0.649 1.938
ENSG00000077463 E017 20.6956019 0.0007592925 3.202163e-01 0.6130394124 19 4175842 4175937 96 - 1.363 1.304 -0.207
ENSG00000077463 E018 16.3770983 0.0168103672 1.493664e-01 0.4116048013 19 4177079 4177138 60 - 1.295 1.171 -0.437
ENSG00000077463 E019 32.8146239 0.0008108694 2.763532e-02 0.1550487181 19 4179104 4179286 183 - 1.577 1.469 -0.370
ENSG00000077463 E020 7.6113108 0.0018317294 3.266587e-06 0.0001299263 19 4179287 4179503 217 - 0.642 1.121 1.854
ENSG00000077463 E021 3.6345606 0.0046292040 5.248362e-05 0.0013875744 19 4180612 4180781 170 - 0.328 0.868 2.501
ENSG00000077463 E022 26.7247138 0.0006198303 6.811059e-01 0.8682494449 19 4180782 4180909 128 - 1.451 1.432 -0.067
ENSG00000077463 E023 0.3724725 0.0168443052 4.913208e-01   19 4182211 4182473 263 - 0.088 0.185 1.237
ENSG00000077463 E024 16.2071081 0.0008759569 4.485024e-01 0.7224902195 19 4182474 4182566 93 - 1.258 1.208 -0.178

Help

Please Click HERE to learn more details about the results from DEXseq.