ENSG00000080815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324501 ENSG00000080815 No_inf pgKDN_inf PSEN1 protein_coding protein_coding 35.26316 24.35302 43.55325 1.386046 2.049449 0.8384187 1.598054 2.577234 2.216928 1.5583427 1.633346 -0.2163557 0.05489167 0.111950 0.052725 -0.059225 0.9260688 0.0116899 FALSE TRUE
ENST00000357710 ENSG00000080815 No_inf pgKDN_inf PSEN1 protein_coding protein_coding 35.26316 24.35302 43.55325 1.386046 2.049449 0.8384187 13.970889 11.627171 16.055559 0.9596251 1.716537 0.4652308 0.40974167 0.481175 0.367950 -0.113225 0.5937522 0.0116899 FALSE TRUE
ENST00000553855 ENSG00000080815 No_inf pgKDN_inf PSEN1 protein_coding nonsense_mediated_decay 35.26316 24.35302 43.55325 1.386046 2.049449 0.8384187 8.207300 1.031933 14.195317 1.0319327 2.624223 3.7690970 0.20226667 0.041825 0.321125 0.279300 0.0116899 0.0116899 TRUE TRUE
ENST00000700435 ENSG00000080815 No_inf pgKDN_inf PSEN1 protein_coding protein_coding_CDS_not_defined 35.26316 24.35302 43.55325 1.386046 2.049449 0.8384187 2.428252 2.866582 1.572108 1.7734798 1.572108 -0.8625075 0.07580833 0.108775 0.040075 -0.068700 0.7358980 0.0116899 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000080815 E001 0.0000000       14 73136418 73136423 6 +      
ENSG00000080815 E002 0.0000000       14 73136424 73136426 3 +      
ENSG00000080815 E003 0.0000000       14 73136427 73136434 8 +      
ENSG00000080815 E004 0.0000000       14 73136435 73136435 1 +      
ENSG00000080815 E005 0.0000000       14 73136436 73136436 1 +      
ENSG00000080815 E006 0.0000000       14 73136437 73136438 2 +      
ENSG00000080815 E007 0.1186381 0.0118442186 6.517723e-01   14 73136439 73136444 6 + 0.086 0.000 -10.815
ENSG00000080815 E008 0.1186381 0.0118442186 6.517723e-01   14 73136445 73136446 2 + 0.086 0.000 -13.083
ENSG00000080815 E009 0.2459004 0.0164744343 8.803164e-01   14 73136447 73136448 2 + 0.086 0.105 0.318
ENSG00000080815 E010 0.1272623 0.0123641623 4.425987e-01   14 73136449 73136450 2 + 0.000 0.105 12.695
ENSG00000080815 E011 0.1272623 0.0123641623 4.425987e-01   14 73136451 73136452 2 + 0.000 0.105 12.695
ENSG00000080815 E012 0.1272623 0.0123641623 4.425987e-01   14 73136453 73136455 3 + 0.000 0.105 12.695
ENSG00000080815 E013 0.3629044 0.0166223144 7.107694e-01   14 73136456 73136460 5 + 0.158 0.105 -0.682
ENSG00000080815 E014 0.7240487 0.1003713053 6.013872e-01 8.256597e-01 14 73136461 73136464 4 + 0.273 0.189 -0.681
ENSG00000080815 E015 0.7240487 0.1003713053 6.013872e-01 8.256597e-01 14 73136465 73136471 7 + 0.273 0.189 -0.681
ENSG00000080815 E016 0.8410527 0.2282649489 5.312424e-01 7.819127e-01 14 73136472 73136476 5 + 0.321 0.189 -1.001
ENSG00000080815 E017 0.9586834 0.0145364023 2.452413e-01 5.356950e-01 14 73136477 73136486 10 + 0.365 0.189 -1.266
ENSG00000080815 E018 1.2126737 0.0663265569 7.789411e-01 9.149984e-01 14 73136487 73136495 9 + 0.364 0.321 -0.266
ENSG00000080815 E019 1.5836679 0.1787699679 8.743631e-01 9.570728e-01 14 73136496 73136506 11 + 0.404 0.422 0.098
ENSG00000080815 E020 1.5836679 0.1787699679 8.743631e-01 9.570728e-01 14 73136507 73136508 2 + 0.404 0.422 0.098
ENSG00000080815 E021 1.9365598 0.1402842876 6.700951e-01 8.629935e-01 14 73136509 73136517 9 + 0.504 0.422 -0.416
ENSG00000080815 E022 3.3805659 0.0125407024 1.779515e-01 4.527401e-01 14 73136518 73136529 12 + 0.713 0.539 -0.759
ENSG00000080815 E023 4.8277158 0.0238761558 1.451583e-01 4.054578e-01 14 73136530 73136540 11 + 0.840 0.658 -0.736
ENSG00000080815 E024 4.2309294 0.0039699224 1.973784e-01 4.786388e-01 14 73136541 73136542 2 + 0.781 0.631 -0.620
ENSG00000080815 E025 8.6989714 0.0066517852 5.264427e-02 2.280317e-01 14 73136543 73136579 37 + 1.061 0.879 -0.681
ENSG00000080815 E026 7.4944476 0.0173705665 1.091377e-01 3.468202e-01 14 73136580 73136583 4 + 0.999 0.829 -0.647
ENSG00000080815 E027 0.0000000       14 73136584 73136585 2 +      
ENSG00000080815 E028 0.2442663 0.0164020340 8.801516e-01   14 73136763 73136816 54 + 0.086 0.105 0.318
ENSG00000080815 E029 1.3501005 0.0092041588 5.383617e-01 7.871254e-01 14 73136817 73137124 308 + 0.321 0.422 0.581
ENSG00000080815 E030 0.8636129 0.0689097022 5.564912e-01 7.987358e-01 14 73137125 73137223 99 + 0.219 0.321 0.733
ENSG00000080815 E031 0.4894115 0.0158355857 8.475153e-01   14 73138107 73138111 5 + 0.158 0.189 0.318
ENSG00000080815 E032 0.4972804 0.0245062330 2.375167e-01   14 73138112 73138152 41 + 0.086 0.260 1.903
ENSG00000080815 E033 0.2543986 0.0160846837 1.828467e-01   14 73139297 73139398 102 + 0.000 0.189 13.635
ENSG00000080815 E034 0.6346750 0.0150286255 1.162335e-02 8.875142e-02 14 73143221 73143483 263 + 0.000 0.374 14.859
ENSG00000080815 E035 0.2541163 0.0160611282 1.829353e-01   14 73145962 73146077 116 + 0.000 0.189 13.635
ENSG00000080815 E036 0.2438580 0.0163963375 8.803119e-01   14 73146078 73146126 49 + 0.086 0.105 0.318
ENSG00000080815 E037 2.4940443 0.0058443588 7.435362e-03 6.579472e-02 14 73146219 73147046 828 + 0.321 0.708 1.903
ENSG00000080815 E038 1.4975651 0.0128910850 3.880740e-02 1.905534e-01 14 73147047 73147491 445 + 0.219 0.539 1.903
ENSG00000080815 E039 0.9763996 0.0166595890 7.876662e-01 9.186284e-01 14 73147492 73147752 261 + 0.273 0.321 0.319
ENSG00000080815 E040 0.3611417 0.0165739779 7.104144e-01   14 73147753 73147794 42 + 0.158 0.105 -0.682
ENSG00000080815 E041 11.0360721 0.0461284360 3.361043e-01 6.279861e-01 14 73147795 73147812 18 + 1.123 1.024 -0.359
ENSG00000080815 E042 20.8036958 0.0217567721 5.222812e-01 7.758907e-01 14 73147813 73147876 64 + 1.356 1.315 -0.141
ENSG00000080815 E043 0.0000000       14 73147943 73147966 24 +      
ENSG00000080815 E044 12.2055786 0.0050237391 8.815349e-01 9.601693e-01 14 73147967 73147977 11 + 1.108 1.133 0.087
ENSG00000080815 E045 13.8866067 0.0009945760 6.403887e-01 8.472849e-01 14 73147978 73147998 21 + 1.183 1.158 -0.089
ENSG00000080815 E046 14.1521139 0.0009511340 9.415806e-01 9.835583e-01 14 73147999 73148010 12 + 1.177 1.182 0.019
ENSG00000080815 E047 14.3845479 0.0009199806 8.105551e-01 9.302003e-01 14 73148011 73148019 9 + 1.189 1.182 -0.026
ENSG00000080815 E048 22.7107638 0.0005923828 6.580630e-02 2.584241e-01 14 73148020 73148094 75 + 1.418 1.316 -0.357
ENSG00000080815 E049 5.2241304 0.0026532181 4.608346e-01 7.319790e-01 14 73148095 73148098 4 + 0.826 0.752 -0.295
ENSG00000080815 E050 4.9707694 0.0028449287 2.711978e-01 5.649583e-01 14 73148099 73148106 8 + 0.826 0.708 -0.475
ENSG00000080815 E051 0.2356421 0.0156609377 3.161515e-01   14 73149348 73149550 203 + 0.158 0.000 -14.014
ENSG00000080815 E052 0.3812526 0.0159178868 7.082769e-02   14 73160009 73160138 130 + 0.000 0.260 14.183
ENSG00000080815 E053 0.8800099 0.0297193459 2.956360e-02 1.616247e-01 14 73160139 73160997 859 + 0.086 0.422 2.903
ENSG00000080815 E054 0.1268540 0.0123173107 4.426503e-01   14 73160998 73161159 162 + 0.000 0.105 12.695
ENSG00000080815 E055 1.2538982 0.0109721725 2.548506e-02 1.471325e-01 14 73161160 73163022 1863 + 0.158 0.503 2.318
ENSG00000080815 E056 0.2537079 0.2360474241 2.292097e-01   14 73165310 73165413 104 + 0.000 0.189 13.204
ENSG00000080815 E057 0.1187032 0.0118709818 6.517131e-01   14 73166839 73167828 990 + 0.086 0.000 -13.083
ENSG00000080815 E058 1.1068719 0.0104722977 5.368977e-01 7.861261e-01 14 73167829 73169363 1535 + 0.273 0.374 0.640
ENSG00000080815 E059 0.1176306 0.0117654419 6.517426e-01   14 73169364 73169461 98 + 0.086 0.000 -13.084
ENSG00000080815 E060 50.1926421 0.0002950982 4.223390e-04 7.654043e-03 14 73170797 73171047 251 + 1.767 1.629 -0.467
ENSG00000080815 E061 0.0000000       14 73171048 73171923 876 +      
ENSG00000080815 E062 0.0000000       14 73173541 73173565 25 +      
ENSG00000080815 E063 32.1514857 0.0053677045 2.240126e-02 1.360880e-01 14 73173566 73173707 142 + 1.573 1.448 -0.427
ENSG00000080815 E064 0.3617709 0.0165789905 7.107626e-01   14 73173708 73174204 497 + 0.158 0.105 -0.682
ENSG00000080815 E065 0.0000000       14 73174254 73174376 123 +      
ENSG00000080815 E066 0.0000000       14 73183139 73183260 122 +      
ENSG00000080815 E067 19.1905411 0.0152751195 1.705581e-01 4.427861e-01 14 73186853 73186920 68 + 1.348 1.247 -0.351
ENSG00000080815 E068 0.0000000       14 73187956 73188071 116 +      
ENSG00000080815 E069 29.3609390 0.0004993147 5.273289e-01 7.793965e-01 14 73192644 73192744 101 + 1.492 1.469 -0.079
ENSG00000080815 E070 39.7785808 0.0005369420 7.977138e-02 2.898989e-01 14 73192745 73192864 120 + 1.641 1.569 -0.245
ENSG00000080815 E071 2.2224987 0.0073981352 1.820052e-01 4.579766e-01 14 73192865 73193579 715 + 0.404 0.603 0.970
ENSG00000080815 E072 3.4708513 0.0041176374 1.689338e-02 1.133807e-01 14 73196512 73198003 1492 + 0.473 0.792 1.396
ENSG00000080815 E073 0.2362687 0.0157113189 3.160497e-01   14 73198004 73198030 27 + 0.158 0.000 -14.013
ENSG00000080815 E074 36.9880883 0.0003999022 9.879539e-01 9.998901e-01 14 73198031 73198129 99 + 1.573 1.585 0.041
ENSG00000080815 E075 0.0000000       14 73206087 73206152 66 +      
ENSG00000080815 E076 0.0000000       14 73206153 73206165 13 +      
ENSG00000080815 E077 0.1268540 0.0123173107 4.426503e-01   14 73206166 73206385 220 + 0.000 0.105 12.695
ENSG00000080815 E078 37.0206372 0.0003973328 6.328879e-01 8.427775e-01 14 73206386 73206472 87 + 1.562 1.597 0.118
ENSG00000080815 E079 7.6759211 0.0023668147 2.545287e-03 3.051290e-02 14 73206473 73208823 2351 + 0.765 1.077 1.181
ENSG00000080815 E080 0.7533168 0.0133154025 5.655645e-02 2.373048e-01 14 73208824 73208915 92 + 0.086 0.374 2.640
ENSG00000080815 E081 10.5837208 0.0013883909 2.711006e-07 1.429281e-05 14 73208916 73211768 2853 + 0.781 1.254 1.749
ENSG00000080815 E082 59.7955923 0.0002534512 2.026962e-01 4.851963e-01 14 73211769 73211942 174 + 1.800 1.762 -0.126
ENSG00000080815 E083 0.1170040 0.0117020944 6.518086e-01   14 73211943 73211985 43 + 0.086 0.000 -13.084
ENSG00000080815 E084 0.3716522 0.1862557129 5.182175e-01   14 73213271 73213610 340 + 0.086 0.189 1.318
ENSG00000080815 E085 0.1272623 0.0123641623 4.425987e-01   14 73216640 73217125 486 + 0.000 0.105 12.695
ENSG00000080815 E086 41.1905082 0.0003381343 2.609757e-02 1.493993e-01 14 73217126 73217244 119 + 1.664 1.572 -0.313
ENSG00000080815 E087 464.3411174 0.0015272097 2.720742e-04 5.369169e-03 14 73219134 73223691 4558 + 2.637 2.699 0.205

Help

Please Click HERE to learn more details about the results from DEXseq.