ENSG00000099875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250896 ENSG00000099875 No_inf pgKDN_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 62.84098 1.234886 2.043406 0.5013482 39.535052 32.817430 42.738519 0.5454319 0.7448038 0.3809726 0.67349167 0.740900 0.682825 -0.058075 7.222423e-01 7.092702e-12 FALSE TRUE
ENST00000309340 ENSG00000099875 No_inf pgKDN_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 62.84098 1.234886 2.043406 0.5013482 6.805399 0.000000 9.132450 0.0000000 0.9152368 9.8364370 0.10146667 0.000000 0.145075 0.145075 7.092702e-12 7.092702e-12 FALSE TRUE
ENST00000589509 ENSG00000099875 No_inf pgKDN_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 62.84098 1.234886 2.043406 0.5013482 4.152676 1.523212 3.916684 0.9973013 2.3170821 1.3567543 0.06338333 0.033075 0.060125 0.027050 9.964134e-01 7.092702e-12 FALSE FALSE
ENST00000591142 ENSG00000099875 No_inf pgKDN_inf MKNK2 protein_coding protein_coding 59.83046 44.39084 62.84098 1.234886 2.043406 0.5013482 3.866601 6.532214 1.343456 1.4877237 1.3434559 -2.2731311 0.07139167 0.145400 0.019600 -0.125800 2.885880e-02 7.092702e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000099875 E001 0.0000000       19 2037465 2037470 6 -      
ENSG00000099875 E002 0.9977019 8.447716e-02 0.1116568403 0.3509995934 19 2037471 2037472 2 - 0.160 0.418 1.861
ENSG00000099875 E003 88.3763618 1.720734e-04 0.0005873300 0.0098959870 19 2037473 2037829 357 - 1.898 2.003 0.352
ENSG00000099875 E004 138.4773313 1.314254e-04 0.0000176590 0.0005550236 19 2037830 2038247 418 - 2.093 2.195 0.342
ENSG00000099875 E005 233.8085730 9.241155e-05 0.0246616253 0.1443094392 19 2038248 2039411 1164 - 2.352 2.390 0.126
ENSG00000099875 E006 48.3402559 3.014263e-04 0.1076809261 0.3440558689 19 2039412 2039630 219 - 1.660 1.726 0.225
ENSG00000099875 E007 59.0165104 2.696393e-04 0.6193579922 0.8353655607 19 2039631 2039856 226 - 1.787 1.766 -0.072
ENSG00000099875 E008 1.8589254 9.854664e-03 0.0983389788 0.3271536196 19 2039857 2039954 98 - 0.325 0.567 1.276
ENSG00000099875 E009 3.4670022 7.194473e-02 0.0884634530 0.3086149983 19 2039955 2040131 177 - 0.508 0.767 1.124
ENSG00000099875 E010 1.4786463 1.143722e-01 0.3960100552 0.6808658837 19 2040132 2040133 2 - 0.325 0.460 0.762
ENSG00000099875 E011 32.2888635 5.296156e-04 0.4178810213 0.6976627458 19 2040134 2040177 44 - 1.542 1.497 -0.152
ENSG00000099875 E012 1.1427816 1.042184e-02 0.0003815331 0.0070350795 19 2040178 2040308 131 - 0.000 0.535 12.226
ENSG00000099875 E013 4.6491271 2.462969e-02 0.5756593060 0.8101151811 19 2040309 2041039 731 - 0.718 0.787 0.276
ENSG00000099875 E014 57.6191728 1.016521e-03 0.9272117646 0.9783495099 19 2041040 2041204 165 - 1.766 1.768 0.006
ENSG00000099875 E015 61.0960060 2.799349e-04 0.0756830418 0.2810831273 19 2041840 2042034 195 - 1.824 1.754 -0.235
ENSG00000099875 E016 0.4902318 1.105067e-01 0.8579374586   19 2042035 2042140 106 - 0.160 0.187 0.276
ENSG00000099875 E017 37.3265032 6.222662e-03 0.0092513382 0.0764457901 19 2042427 2042522 96 - 1.649 1.494 -0.531
ENSG00000099875 E018 38.0270962 1.541892e-03 0.0752901940 0.2801144675 19 2042607 2042662 56 - 1.632 1.540 -0.313
ENSG00000099875 E019 1.6041528 7.335103e-02 0.3003681739 0.5932151671 19 2042663 2042765 103 - 0.325 0.499 0.954
ENSG00000099875 E020 48.3007302 5.566907e-03 0.1978524509 0.4792712368 19 2042766 2042870 105 - 1.723 1.655 -0.231
ENSG00000099875 E021 41.8414814 3.516994e-04 0.0024413304 0.0295822764 19 2043124 2043197 74 - 1.693 1.550 -0.486
ENSG00000099875 E022 34.3880072 4.884497e-04 0.0600147549 0.2458136504 19 2043503 2043582 80 - 1.592 1.494 -0.335
ENSG00000099875 E023 30.8833888 4.312405e-03 0.1186376978 0.3639086386 19 2046186 2046283 98 - 1.545 1.450 -0.324
ENSG00000099875 E024 24.3596798 1.404217e-02 0.0271349744 0.1530855342 19 2046367 2046460 94 - 1.476 1.304 -0.597
ENSG00000099875 E025 9.8496700 5.369633e-03 0.3282201064 0.6207237355 19 2046461 2046468 8 - 1.076 0.983 -0.339
ENSG00000099875 E026 3.1771776 4.564278e-03 0.9170376214 0.9739400209 19 2046522 2046603 82 - 0.614 0.627 0.053
ENSG00000099875 E027 19.5423655 1.825354e-03 0.0697624651 0.2671262786 19 2046604 2046691 88 - 1.366 1.241 -0.437
ENSG00000099875 E028 19.6689082 1.321364e-02 0.2313865194 0.5199616906 19 2050801 2050947 147 - 1.358 1.261 -0.339
ENSG00000099875 E029 18.0105699 7.188936e-03 0.5812639184 0.8133954693 19 2051096 2051217 122 - 1.299 1.254 -0.156
ENSG00000099875 E030 4.9954185 2.827915e-03 0.8780315892 0.9585215207 19 2051218 2051244 27 - 0.786 0.767 -0.078

Help

Please Click HERE to learn more details about the results from DEXseq.