ENSG00000105221

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311278 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding protein_coding 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 3.707266 3.072687 7.6447936 3.0726866 2.6800427 1.3121752 0.07079167 0.048800 0.154425 0.105625 0.279054826 0.005151493 FALSE TRUE
ENST00000358335 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding protein_coding 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 2.572527 0.000000 3.4960315 0.0000000 2.0187570 8.4536951 0.04784167 0.000000 0.062350 0.062350 0.452937401 0.005151493 FALSE FALSE
ENST00000391844 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding nonsense_mediated_decay 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 10.123485 3.991537 11.0080107 3.1339287 3.3956379 1.4612375 0.20325833 0.091375 0.206950 0.115575 0.380940252 0.005151493 FALSE TRUE
ENST00000392038 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding protein_coding 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 5.414271 5.980972 5.9122891 2.0259750 1.1240734 -0.0166352 0.10757500 0.120375 0.116150 -0.004225 0.960554807 0.005151493 FALSE TRUE
ENST00000476247 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding protein_coding 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 3.384548 0.000000 10.1536435 0.0000000 3.7101566 9.9892020 0.06243333 0.000000 0.187300 0.187300 0.005151493 0.005151493 FALSE FALSE
ENST00000476266 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding retained_intron 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 4.435880 1.865932 6.6807772 0.5141091 1.6788154 1.8345659 0.08639167 0.036550 0.125375 0.088825 0.137138992 0.005151493 FALSE TRUE
ENST00000483166 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding retained_intron 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 3.601225 4.299290 2.5251305 0.2391930 0.5064158 -0.7653902 0.07359167 0.088200 0.050850 -0.037350 0.618609570 0.005151493 FALSE TRUE
ENST00000489375 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding nonsense_mediated_decay 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 1.570248 4.364986 0.0000000 2.1692325 0.0000000 -8.7731347 0.02923333 0.080550 0.000000 -0.080550 0.024347919 0.005151493   FALSE
ENST00000496089 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding retained_intron 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 1.358346 2.893206 0.4452365 2.3055182 0.2648219 -2.6729587 0.02843333 0.060700 0.009350 -0.051350 0.774407473 0.005151493 FALSE TRUE
ENST00000584288 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding nonsense_mediated_decay 50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 3.302420 4.630934 1.7890361 2.6760074 1.7890361 -1.3671911 0.07147500 0.097525 0.041000 -0.056525 0.806704598 0.005151493 FALSE TRUE
MSTRG.15168.3 ENSG00000105221 No_inf pgKDN_inf AKT2 protein_coding   50.46355 50.25378 51.98087 4.371385 3.003372 0.04873893 1.375620 2.908445 0.0000000 2.0943971 0.0000000 -8.1890562 0.02948333 0.060900 0.000000 -0.060900 0.128771535 0.005151493 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000105221 E001 0.0000000       19 40230317 40230317 1 -      
ENSG00000105221 E002 1.1069072 0.2400073817 8.664662e-01 9.539942e-01 19 40230318 40230575 258 - 0.303 0.340 0.229
ENSG00000105221 E003 29.7300185 0.0120817113 1.260616e-06 5.701443e-05 19 40230576 40232334 1759 - 1.260 1.619 1.239
ENSG00000105221 E004 0.9988698 0.1502603695 2.392354e-01 5.281805e-01 19 40232335 40232336 2 - 0.178 0.384 1.493
ENSG00000105221 E005 194.4238995 0.0001279705 1.332192e-01 3.876891e-01 19 40232337 40233667 1331 - 2.302 2.279 -0.075
ENSG00000105221 E006 11.4489649 0.0014667747 6.894286e-02 2.652854e-01 19 40233668 40233669 2 - 1.166 1.021 -0.524
ENSG00000105221 E007 17.9778819 0.0007712844 3.684930e-01 6.570017e-01 19 40233670 40233747 78 - 1.305 1.251 -0.189
ENSG00000105221 E008 6.2548184 0.0022627754 8.973888e-01 9.661308e-01 19 40233748 40233754 7 - 0.849 0.869 0.079
ENSG00000105221 E009 9.9845464 0.0013415322 1.943496e-01 4.742128e-01 19 40233755 40233780 26 - 0.970 1.093 0.449
ENSG00000105221 E010 13.6569145 0.0046427413 4.453743e-01 7.197621e-01 19 40233781 40233820 40 - 1.126 1.196 0.248
ENSG00000105221 E011 12.5928100 0.0011017546 7.740622e-02 2.846214e-01 19 40233821 40233840 20 - 1.046 1.196 0.541
ENSG00000105221 E012 14.7763688 0.0009805539 2.326342e-01 5.213046e-01 19 40233841 40233875 35 - 1.143 1.240 0.345
ENSG00000105221 E013 11.2894051 0.0015729465 8.163129e-01 9.329933e-01 19 40233876 40233878 3 - 1.074 1.101 0.097
ENSG00000105221 E014 27.3441794 0.0090501133 9.722471e-01 9.947660e-01 19 40233879 40233951 73 - 1.448 1.455 0.025
ENSG00000105221 E015 0.1272623 0.0124185232 5.827073e-01   19 40234449 40234497 49 - 0.000 0.092 12.608
ENSG00000105221 E016 0.4980357 0.0338195841 3.640516e-01   19 40234498 40234571 74 - 0.098 0.233 1.494
ENSG00000105221 E017 2.3925584 0.0058501409 5.036387e-04 8.793541e-03 19 40234572 40235044 473 - 0.178 0.702 2.996
ENSG00000105221 E018 29.4981652 0.0041443660 4.088707e-01 6.910897e-01 19 40235045 40235100 56 - 1.452 1.509 0.198
ENSG00000105221 E019 16.4896255 0.0015207561 2.851896e-01 5.788796e-01 19 40235101 40235101 1 - 1.195 1.279 0.299
ENSG00000105221 E020 25.3258037 0.0049683275 4.702903e-01 7.381211e-01 19 40235102 40235147 46 - 1.389 1.444 0.190
ENSG00000105221 E021 35.6354672 0.0032002609 5.085054e-01 7.667567e-01 19 40235263 40235350 88 - 1.539 1.582 0.148
ENSG00000105221 E022 0.8872193 0.0377839254 7.045669e-03 6.334408e-02 19 40235351 40235467 117 - 0.000 0.425 15.142
ENSG00000105221 E023 17.6372394 0.0215746121 6.608027e-01 8.584578e-01 19 40235890 40235893 4 - 1.289 1.251 -0.132
ENSG00000105221 E024 49.5206075 0.0023807297 4.314714e-03 4.473533e-02 19 40235894 40236023 130 - 1.764 1.640 -0.420
ENSG00000105221 E025 22.4031396 0.0098918980 4.089364e-02 1.962589e-01 19 40236024 40236031 8 - 1.440 1.295 -0.502
ENSG00000105221 E026 28.4748020 0.0160758226 3.610237e-02 1.824300e-01 19 40236032 40236104 73 - 1.545 1.389 -0.538
ENSG00000105221 E027 0.1272623 0.0124185232 5.827073e-01   19 40236105 40236142 38 - 0.000 0.092 12.608
ENSG00000105221 E028 0.3618970 0.0166045939 5.351808e-01   19 40236143 40236237 95 - 0.178 0.092 -1.091
ENSG00000105221 E029 0.4902590 0.0158830694 9.357423e-01   19 40236238 40236256 19 - 0.178 0.169 -0.091
ENSG00000105221 E030 17.2051670 0.0017836833 4.893070e-01 7.522672e-01 19 40236257 40236301 45 - 1.228 1.285 0.198
ENSG00000105221 E031 24.3369662 0.0005529182 3.940536e-01 6.788397e-01 19 40236302 40236385 84 - 1.371 1.429 0.201
ENSG00000105221 E032 4.4549981 0.0178938487 1.811938e-01 4.570381e-01 19 40236386 40237060 675 - 0.632 0.810 0.732
ENSG00000105221 E033 8.1081855 0.0017149995 1.251674e-04 2.849631e-03 19 40237061 40237968 908 - 0.703 1.101 1.523
ENSG00000105221 E034 17.0890814 0.0038890252 4.473725e-01 7.215080e-01 19 40237969 40237989 21 - 1.222 1.285 0.221
ENSG00000105221 E035 31.6490127 0.0005548247 9.213252e-01 9.754609e-01 19 40237990 40238091 102 - 1.506 1.519 0.043
ENSG00000105221 E036 16.9031747 0.0013985605 7.628250e-01 9.074516e-01 19 40238905 40238941 37 - 1.260 1.246 -0.049
ENSG00000105221 E037 17.1482615 0.0056083543 7.688335e-01 9.106268e-01 19 40238942 40238973 32 - 1.266 1.251 -0.050
ENSG00000105221 E038 4.5840520 0.0098465831 6.542133e-02 2.576043e-01 19 40238974 40239500 527 - 0.605 0.841 0.968
ENSG00000105221 E039 4.2922370 0.0439371438 1.606361e-05 5.120417e-04 19 40239590 40240044 455 - 0.245 0.922 3.278
ENSG00000105221 E040 14.8287440 0.0009608258 8.632390e-01 9.527896e-01 19 40240045 40240069 25 - 1.202 1.196 -0.020
ENSG00000105221 E041 19.3075819 0.0007249240 1.939829e-01 4.737705e-01 19 40240070 40240110 41 - 1.347 1.268 -0.274
ENSG00000105221 E042 0.0000000       19 40240111 40240121 11 -      
ENSG00000105221 E043 0.0000000       19 40240262 40240299 38 -      
ENSG00000105221 E044 0.2536433 0.0159382814 2.714582e-01   19 40240791 40240946 156 - 0.000 0.169 13.555
ENSG00000105221 E045 0.9780364 0.0116475428 9.098986e-01 9.714619e-01 19 40240947 40241937 991 - 0.303 0.290 -0.091
ENSG00000105221 E046 13.7930721 0.0032674037 1.572992e-01 4.238542e-01 19 40241938 40241958 21 - 1.222 1.117 -0.373
ENSG00000105221 E047 23.0699906 0.0008714042 7.557419e-02 2.807949e-01 19 40241959 40242034 76 - 1.432 1.330 -0.352
ENSG00000105221 E048 11.5893154 0.0012358177 1.917292e-01 4.714496e-01 19 40242035 40242039 5 - 1.150 1.049 -0.365
ENSG00000105221 E049 12.5704944 0.0011279639 1.980160e-01 4.793885e-01 19 40242040 40242055 16 - 1.180 1.084 -0.344
ENSG00000105221 E050 11.9677003 0.0011432447 3.174438e-01 6.102443e-01 19 40242056 40242069 14 - 1.150 1.076 -0.268
ENSG00000105221 E051 0.1187032 0.0118191557 4.967147e-01   19 40242070 40242533 464 - 0.098 0.000 -13.403
ENSG00000105221 E052 15.1642659 0.0009219508 4.206315e-01 6.998756e-01 19 40242534 40242572 39 - 1.235 1.183 -0.184
ENSG00000105221 E053 9.6678918 0.0016514913 6.394840e-01 8.466496e-01 19 40242573 40242573 1 - 1.046 1.011 -0.128
ENSG00000105221 E054 9.9136663 0.0021698812 6.382086e-01 8.458083e-01 19 40242574 40242576 3 - 1.055 1.021 -0.127
ENSG00000105221 E055 10.1578039 0.0016779621 6.348933e-01 8.440054e-01 19 40242577 40242583 7 - 1.065 1.030 -0.126
ENSG00000105221 E056 9.1973354 0.0017982249 9.959905e-01 1.000000e+00 19 40242584 40242589 6 - 1.004 1.011 0.024
ENSG00000105221 E057 12.0969151 0.0011494329 3.690710e-01 6.574439e-01 19 40242590 40242615 26 - 1.150 1.084 -0.237
ENSG00000105221 E058 10.7678181 0.0015992246 5.593015e-01 8.005013e-01 19 40242616 40242627 12 - 1.092 1.049 -0.157
ENSG00000105221 E059 11.8191771 0.0012875430 8.876710e-02 3.090930e-01 19 40242628 40242652 25 - 1.173 1.040 -0.480
ENSG00000105221 E060 11.7052163 0.0011711780 1.077501e-01 3.441544e-01 19 40242653 40242676 24 - 1.166 1.040 -0.454
ENSG00000105221 E061 10.7444338 0.0043227410 2.369398e-01 5.259342e-01 19 40242677 40242687 11 - 1.118 1.021 -0.354
ENSG00000105221 E062 0.4985712 0.0274877221 3.629040e-01   19 40242688 40244127 1440 - 0.098 0.233 1.494
ENSG00000105221 E063 0.0000000       19 40244319 40244414 96 -      
ENSG00000105221 E064 24.3713358 0.0006015458 6.194283e-01 8.353942e-01 19 40255158 40255243 86 - 1.415 1.393 -0.077
ENSG00000105221 E065 14.4645161 0.0023584550 9.486043e-01 9.867315e-01 19 40255244 40255269 26 - 1.188 1.189 0.007
ENSG00000105221 E066 0.1268540 0.0124165773 5.826871e-01   19 40255270 40255299 30 - 0.000 0.092 12.608
ENSG00000105221 E067 22.4274029 0.0029793684 7.592993e-01 9.055179e-01 19 40256926 40257054 129 - 1.375 1.363 -0.044
ENSG00000105221 E068 10.9120328 0.0020391406 9.472056e-01 9.860182e-01 19 40265222 40265258 37 - 1.074 1.076 0.006
ENSG00000105221 E069 15.1932245 0.0009132470 7.887053e-01 9.189047e-01 19 40265259 40265351 93 - 1.215 1.202 -0.045
ENSG00000105221 E070 0.8626692 0.0146759697 7.890543e-01 9.190156e-01 19 40265352 40265547 196 - 0.245 0.290 0.324
ENSG00000105221 E071 0.2537079 0.3149440838 3.438652e-01   19 40266011 40266205 195 - 0.000 0.169 12.914
ENSG00000105221 E072 0.8869984 0.0882895041 9.692345e-03 7.876253e-02 19 40266206 40266359 154 - 0.000 0.425 14.989
ENSG00000105221 E073 0.6353043 0.0149563194 2.565172e-02 1.478888e-01 19 40267387 40267574 188 - 0.000 0.340 14.792
ENSG00000105221 E074 0.7609946 0.0136824156 1.235147e-02 9.204978e-02 19 40268584 40268641 58 - 0.000 0.384 15.035
ENSG00000105221 E075 0.5070043 0.0156826177 5.443816e-02 2.323390e-01 19 40268642 40268685 44 - 0.000 0.290 14.494
ENSG00000105221 E076 0.6342667 0.0142110569 2.556447e-02 1.475322e-01 19 40268686 40269085 400 - 0.000 0.340 14.795
ENSG00000105221 E077 0.4989181 0.0359334360 3.641806e-01   19 40269423 40269540 118 - 0.098 0.233 1.494
ENSG00000105221 E078 0.3802150 0.0372048941 1.226431e-01   19 40269541 40269589 49 - 0.000 0.233 14.022
ENSG00000105221 E079 0.7615936 0.0351546870 1.347550e-02 9.756849e-02 19 40270498 40270769 272 - 0.000 0.384 14.952
ENSG00000105221 E080 2.2594384 0.0062156320 5.794001e-03 5.503587e-02 19 40279107 40279639 533 - 0.245 0.659 2.231
ENSG00000105221 E081 3.1317446 0.0957239742 2.248898e-02 1.363538e-01 19 40279738 40280087 350 - 0.355 0.759 1.908
ENSG00000105221 E082 2.2565139 0.0097506008 6.169861e-03 5.760174e-02 19 40280088 40280416 329 - 0.245 0.659 2.231
ENSG00000105221 E083 0.2533610 0.0160396163 2.712161e-01   19 40280782 40280832 51 - 0.000 0.169 13.554
ENSG00000105221 E084 0.6244813 0.0152963555 2.021706e-01 4.846130e-01 19 40282217 40282247 31 - 0.098 0.290 1.909
ENSG00000105221 E085 1.0060163 0.0114056206 3.458848e-02 1.777001e-01 19 40282248 40282304 57 - 0.098 0.425 2.716
ENSG00000105221 E086 0.7620969 0.0282185328 1.313544e-02 9.602151e-02 19 40282305 40282444 140 - 0.000 0.384 14.977
ENSG00000105221 E087 0.7529073 0.3521872339 2.616281e-01 5.543252e-01 19 40282708 40282776 69 - 0.098 0.340 2.232
ENSG00000105221 E088 2.6571565 0.0284246120 2.845715e-05 8.291778e-04 19 40282777 40283165 389 - 0.098 0.759 4.231
ENSG00000105221 E089 0.0000000       19 40284765 40284863 99 -      
ENSG00000105221 E090 0.0000000       19 40284864 40285048 185 -      
ENSG00000105221 E091 0.0000000       19 40285049 40285180 132 -      
ENSG00000105221 E092 12.6635540 0.0085418778 7.299359e-02 2.745423e-01 19 40285181 40285395 215 - 1.208 1.058 -0.539
ENSG00000105221 E093 0.0000000       19 40285448 40285536 89 -      

Help

Please Click HERE to learn more details about the results from DEXseq.