ENSG00000105329

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221930 ENSG00000105329 No_inf pgKDN_inf TGFB1 protein_coding protein_coding 408.8648 203.3519 481.6563 7.656648 9.563115 1.243985 204.24050 102.20531 241.89207 1.940349 3.546903 1.2428118 0.5014583 0.505125 0.502900 -0.002225 1.000000000 0.007090645 FALSE  
ENST00000597453 ENSG00000105329 No_inf pgKDN_inf TGFB1 protein_coding retained_intron 408.8648 203.3519 481.6563 7.656648 9.563115 1.243985 51.74998 34.80151 48.62347 5.083001 6.014117 0.4823851 0.1339917 0.169050 0.100425 -0.068625 0.156856112 0.007090645 FALSE  
ENST00000677934 ENSG00000105329 No_inf pgKDN_inf TGFB1 protein_coding protein_coding 408.8648 203.3519 481.6563 7.656648 9.563115 1.243985 135.20485 52.47200 167.93351 2.674392 2.778754 1.6780814 0.3162000 0.257800 0.348950 0.091150 0.007090645 0.007090645 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000105329 E001 0.4913966 8.093514e-02 0.448288377   19 41301587 41301746 160 - 0.124 0.237 1.134
ENSG00000105329 E002 0.0000000       19 41302624 41302720 97 -      
ENSG00000105329 E003 15.5321449 1.794073e-02 0.001889717 0.02451178 19 41330323 41330914 592 - 1.076 1.364 1.021
ENSG00000105329 E004 366.7731915 8.291055e-05 0.121661556 0.36925171 19 41330915 41331210 296 - 2.547 2.521 -0.087
ENSG00000105329 E005 3.0484890 5.957390e-02 0.233266957 0.52209902 19 41332040 41332127 88 - 0.520 0.698 0.787
ENSG00000105329 E006 489.5497272 6.138169e-04 0.647791760 0.85124413 19 41332128 41332281 154 - 2.661 2.669 0.025
ENSG00000105329 E007 515.7429117 4.928985e-05 0.096148476 0.32299420 19 41341883 41342020 138 - 2.679 2.701 0.075
ENSG00000105329 E008 198.1330379 9.056046e-05 0.081729315 0.29408158 19 41342021 41342030 10 - 2.259 2.298 0.131
ENSG00000105329 E009 11.9418264 6.856205e-03 0.014900627 0.10464198 19 41342031 41342169 139 - 1.004 1.220 0.780
ENSG00000105329 E010 360.8211115 2.822387e-04 0.017125503 0.11445438 19 41342170 41342247 78 - 2.517 2.559 0.138
ENSG00000105329 E011 386.3566561 5.639983e-05 0.857903212 0.95043756 19 41344747 41344864 118 - 2.560 2.563 0.009
ENSG00000105329 E012 490.5740419 5.582792e-04 0.252623796 0.54411734 19 41348295 41348455 161 - 2.671 2.651 -0.064
ENSG00000105329 E013 1644.4134551 6.330552e-05 0.006095657 0.05715298 19 41352690 41353922 1233 - 3.195 3.177 -0.062

Help

Please Click HERE to learn more details about the results from DEXseq.