ENSG00000105397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000525621 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding protein_coding 114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 11.346309 0.000000 22.816945 0.0000000 1.5817929 11.15652209 0.09229167 0.000000 0.198500 0.198500 6.256891e-26 6.256891e-26 FALSE TRUE
ENST00000529739 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding retained_intron 114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 5.740366 6.087186 5.939966 0.5837409 0.7247592 -0.03526205 0.05456667 0.075400 0.052275 -0.023125 7.839164e-01 6.256891e-26 TRUE TRUE
ENST00000530220 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding retained_intron 114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 7.322514 6.267416 5.116993 0.6117176 1.8461123 -0.29205791 0.06495000 0.075925 0.046050 -0.029875 7.695191e-01 6.256891e-26 FALSE FALSE
ENST00000699356 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding retained_intron 114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 17.919409 14.726396 8.260202 1.1724365 2.6789479 -0.83338930 0.15522500 0.181300 0.071350 -0.109950 1.123765e-01 6.256891e-26 TRUE TRUE
ENST00000699361 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding retained_intron 114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 20.477257 19.124520 20.708623 1.5716619 0.6845033 0.11475046 0.18705833 0.231750 0.180350 -0.051400 5.580577e-01 6.256891e-26 FALSE FALSE
MSTRG.14503.1 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding   114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 9.666121 4.625857 6.345635 1.6124000 2.6353368 0.45520004 0.07850833 0.054875 0.055450 0.000575 1.000000e+00 6.256891e-26 FALSE TRUE
MSTRG.14503.3 ENSG00000105397 No_inf pgKDN_inf TYK2 protein_coding   114.3943 82.37596 115.3906 5.434632 4.095756 0.4861808 6.806374 6.373137 5.948325 0.3984766 1.6215773 -0.09935876 0.06165833 0.078975 0.050500 -0.028475 6.540657e-01 6.256891e-26 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000105397 E001 0.1187032 0.0118621715 6.920230e-01   19 10350448 10350457 10 - 0.085 0.000 -9.963
ENSG00000105397 E002 1.0975599 0.0115952042 9.648729e-01 9.925984e-01 19 10350458 10350532 75 - 0.317 0.325 0.050
ENSG00000105397 E003 1.4620375 0.0091416015 8.876641e-01 9.624138e-01 19 10350533 10350534 2 - 0.399 0.379 -0.114
ENSG00000105397 E004 3.5324703 0.0097529000 8.081035e-01 9.291769e-01 19 10350535 10350544 10 - 0.668 0.638 -0.131
ENSG00000105397 E005 4.7406056 0.0031509000 5.126733e-01 7.696521e-01 19 10350545 10350548 4 - 0.790 0.714 -0.306
ENSG00000105397 E006 4.8582363 0.0030995903 4.320678e-01 7.095532e-01 19 10350549 10350550 2 - 0.805 0.714 -0.365
ENSG00000105397 E007 4.9850902 0.0031109452 5.496286e-01 7.943531e-01 19 10350551 10350554 4 - 0.805 0.737 -0.272
ENSG00000105397 E008 5.1020942 0.0028475503 4.668841e-01 7.355101e-01 19 10350555 10350556 2 - 0.819 0.737 -0.329
ENSG00000105397 E009 8.2779523 0.0019097367 6.771736e-01 8.661643e-01 19 10350557 10350568 12 - 0.983 0.944 -0.143
ENSG00000105397 E010 10.2272562 0.0013633198 7.083559e-01 8.817704e-01 19 10350569 10350576 8 - 1.062 1.031 -0.114
ENSG00000105397 E011 69.2618668 0.0002040668 8.829305e-01 9.605624e-01 19 10350577 10350747 171 - 1.842 1.849 0.025
ENSG00000105397 E012 68.0856620 0.0002251870 4.765285e-01 7.430207e-01 19 10350748 10350852 105 - 1.848 1.824 -0.081
ENSG00000105397 E013 98.7348225 0.0020497102 6.025229e-01 8.265496e-01 19 10350853 10350946 94 - 1.988 2.008 0.067
ENSG00000105397 E014 56.9571850 0.0025868275 2.326895e-01 5.213046e-01 19 10350947 10350968 22 - 1.735 1.790 0.186
ENSG00000105397 E015 78.2537230 0.0002071724 3.876917e-01 6.733790e-01 19 10351052 10351143 92 - 1.883 1.914 0.105
ENSG00000105397 E016 33.9912899 0.0067428220 6.816211e-01 8.682781e-01 19 10351144 10351162 19 - 1.552 1.530 -0.077
ENSG00000105397 E017 13.8409209 0.0009400854 7.650210e-05 1.899661e-03 19 10351163 10351484 322 - 1.002 1.312 1.109
ENSG00000105397 E018 67.0170913 0.0027293173 1.776423e-01 4.522660e-01 19 10352434 10352551 118 - 1.855 1.800 -0.185
ENSG00000105397 E019 13.1152042 0.0010392366 1.138501e-01 3.552644e-01 19 10352552 10352785 234 - 1.086 1.213 0.453
ENSG00000105397 E020 29.8919487 0.0021133076 8.149266e-01 9.323955e-01 19 10352926 10352957 32 - 1.481 1.496 0.052
ENSG00000105397 E021 22.3932890 0.0176463960 6.053078e-01 8.279863e-01 19 10352958 10352967 10 - 1.385 1.346 -0.136
ENSG00000105397 E022 63.9925729 0.0002571504 2.553091e-01 5.472455e-01 19 10352968 10353098 131 - 1.829 1.788 -0.138
ENSG00000105397 E023 38.3829413 0.0007535588 1.674599e-05 5.302441e-04 19 10353099 10353527 429 - 1.484 1.697 0.725
ENSG00000105397 E024 60.5334817 0.0002457964 9.083321e-02 3.130350e-01 19 10353528 10353646 119 - 1.815 1.751 -0.216
ENSG00000105397 E025 47.4685308 0.0027968658 1.268257e-08 8.860383e-07 19 10353647 10353813 167 - 1.536 1.813 0.941
ENSG00000105397 E026 38.9608328 0.0027354289 4.173507e-07 2.099757e-05 19 10353814 10353929 116 - 1.459 1.725 0.907
ENSG00000105397 E027 29.8654260 0.0100298059 3.666906e-05 1.024189e-03 19 10353930 10354041 112 - 1.336 1.620 0.976
ENSG00000105397 E028 87.1612089 0.0042207960 3.647222e-01 6.532805e-01 19 10354042 10354234 193 - 1.959 1.924 -0.117
ENSG00000105397 E029 49.4138299 0.0002973012 3.439593e-01 6.353335e-01 19 10354512 10354609 98 - 1.718 1.679 -0.131
ENSG00000105397 E030 60.4385068 0.0002680316 3.835585e-01 6.696288e-01 19 10356568 10356718 151 - 1.770 1.806 0.120
ENSG00000105397 E031 17.8082826 0.0007959359 3.295894e-06 1.308989e-04 19 10356719 10357763 1045 - 1.094 1.421 1.152
ENSG00000105397 E032 61.2502459 0.0008886807 6.108072e-01 8.306843e-01 19 10357764 10357918 155 - 1.801 1.782 -0.062
ENSG00000105397 E033 44.5077839 0.0003223126 1.718396e-01 4.444870e-01 19 10358003 10358138 136 - 1.682 1.622 -0.203
ENSG00000105397 E034 2.9335466 0.1643900542 6.789045e-01 8.672060e-01 19 10358334 10358610 277 - 0.554 0.638 0.374
ENSG00000105397 E035 47.8279499 0.0003195297 4.296823e-01 7.078556e-01 19 10359175 10359302 128 - 1.701 1.669 -0.110
ENSG00000105397 E036 2.0930595 0.0067512222 2.181593e-01 5.046460e-01 19 10360962 10361073 112 - 0.399 0.578 0.886
ENSG00000105397 E037 0.2537694 0.0160558047 1.673067e-01   19 10361305 10361510 206 - 0.000 0.192 11.599
ENSG00000105397 E038 43.4000708 0.0037954499 2.137459e-02 1.324468e-01 19 10361511 10361598 88 - 1.696 1.577 -0.404
ENSG00000105397 E039 41.6319640 0.0003360055 2.580338e-04 5.150554e-03 19 10361770 10361836 67 - 1.698 1.526 -0.585
ENSG00000105397 E040 43.9604048 0.0003832092 5.358096e-02 2.304861e-01 19 10361837 10361920 84 - 1.688 1.602 -0.293
ENSG00000105397 E041 28.4329251 0.0008304237 5.903710e-01 8.186857e-01 19 10361921 10361955 35 - 1.452 1.484 0.111
ENSG00000105397 E042 53.5014162 0.0003462561 8.577045e-01 9.503541e-01 19 10362078 10362181 104 - 1.737 1.732 -0.019
ENSG00000105397 E043 0.3809057 0.0158039445 6.300025e-02   19 10362182 10362214 33 - 0.000 0.264 12.184
ENSG00000105397 E044 57.8963442 0.0002722829 1.378013e-01 3.950394e-01 19 10362264 10362456 193 - 1.793 1.736 -0.193
ENSG00000105397 E045 23.6279576 0.0049290196 6.274618e-01 8.399455e-01 19 10362549 10362579 31 - 1.403 1.372 -0.109
ENSG00000105397 E046 35.2053702 0.0004378800 6.955878e-01 8.757606e-01 19 10362580 10362657 78 - 1.565 1.547 -0.061
ENSG00000105397 E047 3.3164931 0.0048407385 2.241040e-01 5.117150e-01 19 10364146 10364517 372 - 0.554 0.714 0.694
ENSG00000105397 E048 0.7611206 0.0132944519 3.926493e-03 4.191834e-02 19 10364518 10364613 96 - 0.000 0.427 13.184
ENSG00000105397 E049 52.5198136 0.0022757064 9.736229e-01 9.952875e-01 19 10364614 10364771 158 - 1.727 1.727 0.002
ENSG00000105397 E050 0.7436814 0.0137442149 2.625901e-01 5.554352e-01 19 10364772 10364850 79 - 0.155 0.325 1.372
ENSG00000105397 E051 52.4907783 0.0002955445 6.708782e-01 8.633122e-01 19 10364851 10365048 198 - 1.734 1.718 -0.053
ENSG00000105397 E052 5.9598617 0.0037495069 6.043081e-04 1.012197e-02 19 10365049 10365516 468 - 0.626 1.008 1.509
ENSG00000105397 E053 89.1175633 0.0001870632 3.322727e-01 6.244566e-01 19 10365517 10365898 382 - 1.966 1.937 -0.098
ENSG00000105397 E054 66.0714707 0.0002214306 2.127831e-01 4.979858e-01 19 10366417 10366580 164 - 1.844 1.800 -0.149
ENSG00000105397 E055 22.5262104 0.0009106238 7.851629e-01 9.171742e-01 19 10368055 10368062 8 - 1.377 1.362 -0.052
ENSG00000105397 E056 39.5910062 0.0054957986 7.881537e-01 9.187606e-01 19 10368063 10368121 59 - 1.613 1.599 -0.049
ENSG00000105397 E057 33.4096299 0.0068912629 9.659761e-01 9.930363e-01 19 10368122 10368179 58 - 1.536 1.533 -0.010
ENSG00000105397 E058 18.0590257 0.0045489420 9.573402e-01 9.898200e-01 19 10368180 10368202 23 - 1.276 1.281 0.019
ENSG00000105397 E059 23.6814491 0.0006038906 1.408814e-01 3.993009e-01 19 10368295 10368371 77 - 1.428 1.340 -0.306
ENSG00000105397 E060 24.1205997 0.0006441276 2.244514e-02 1.362186e-01 19 10368372 10368418 47 - 1.456 1.317 -0.479
ENSG00000105397 E061 0.2441377 0.0164582287 8.444506e-01   19 10368419 10368531 113 - 0.085 0.107 0.372
ENSG00000105397 E062 1.7152048 0.0075882758 6.406242e-01 8.474688e-01 19 10368532 10368741 210 - 0.399 0.470 0.372
ENSG00000105397 E063 2.5014650 0.0058573499 4.147015e-03 4.359094e-02 19 10369757 10369877 121 - 0.688 0.264 -2.213
ENSG00000105397 E064 55.0654299 0.0002651392 8.732883e-02 3.063609e-01 19 10378214 10378426 213 - 1.776 1.709 -0.229
ENSG00000105397 E065 27.2541597 0.0018210144 4.435006e-01 7.183327e-01 19 10379615 10379689 75 - 1.468 1.425 -0.149
ENSG00000105397 E066 30.3637418 0.0005163191 9.826974e-01 9.986903e-01 19 10379690 10379779 90 - 1.493 1.496 0.011
ENSG00000105397 E067 30.9693814 0.0005184855 9.977506e-01 1.000000e+00 19 10380380 10380509 130 - 1.502 1.504 0.006
ENSG00000105397 E068 5.9702935 0.0023507276 9.055264e-01 9.697621e-01 19 10380510 10380608 99 - 0.847 0.835 -0.043

Help

Please Click HERE to learn more details about the results from DEXseq.