ENSG00000105401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222005 ENSG00000105401 No_inf pgKDN_inf CDC37 protein_coding protein_coding 256.3737 288.5168 228.1626 3.174093 4.452191 -0.3385796 194.16595 201.05603 196.45149 1.336656 1.941725 -0.0334228 0.7642667 0.697 0.86180 0.16480 2.017455e-09 4.786229e-10 FALSE TRUE
ENST00000591248 ENSG00000105401 No_inf pgKDN_inf CDC37 protein_coding retained_intron 256.3737 288.5168 228.1626 3.174093 4.452191 -0.3385796 41.46631 65.67751 16.37407 2.375392 1.707883 -2.0033253 0.1560333 0.228 0.07165 -0.15635 4.786229e-10 4.786229e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000105401 E001 254.2878506 1.085612e-03 1.955569e-01 4.758850e-01 19 10391133 10391452 320 - 2.416 2.387 -0.099
ENSG00000105401 E002 163.6987321 1.220619e-04 1.270095e-01 3.777715e-01 19 10391453 10391517 65 - 2.230 2.193 -0.122
ENSG00000105401 E003 316.4073477 8.270220e-05 9.029930e-01 9.688647e-01 19 10391518 10391706 189 - 2.495 2.492 -0.008
ENSG00000105401 E004 0.5075387 4.938403e-02 9.649380e-02 3.235170e-01 19 10392776 10393084 309 - 0.000 0.264 12.553
ENSG00000105401 E005 0.1170040 1.168694e-02 3.887295e-01   19 10393085 10393085 1 - 0.110 0.000 -11.579
ENSG00000105401 E006 106.7938245 2.277557e-04 9.911760e-01 1.000000e+00 19 10393086 10393094 9 - 2.024 2.024 0.000
ENSG00000105401 E007 179.0037125 1.176564e-04 5.716498e-01 8.078015e-01 19 10393095 10393157 63 - 2.255 2.242 -0.044
ENSG00000105401 E008 89.5691884 1.848792e-04 3.959336e-01 6.808315e-01 19 10393259 10393259 1 - 1.965 1.937 -0.093
ENSG00000105401 E009 113.1186781 1.465498e-04 5.516964e-01 7.955052e-01 19 10393260 10393279 20 - 2.059 2.042 -0.059
ENSG00000105401 E010 113.4138022 1.550812e-04 7.356363e-01 8.951583e-01 19 10393280 10393290 11 - 2.056 2.046 -0.034
ENSG00000105401 E011 282.6731552 7.463569e-04 2.584393e-01 5.507933e-01 19 10393291 10393407 117 - 2.459 2.435 -0.080
ENSG00000105401 E012 139.5429961 3.432838e-04 4.330615e-01 7.105596e-01 19 10393408 10393441 34 - 2.152 2.131 -0.071
ENSG00000105401 E013 2.3761023 9.811248e-02 1.309052e-01 3.837713e-01 19 10393442 10393786 345 - 0.332 0.616 1.447
ENSG00000105401 E014 101.4400067 2.128551e-03 7.709032e-01 9.116359e-01 19 10395021 10395022 2 - 2.009 1.998 -0.037
ENSG00000105401 E015 116.1524540 1.432408e-03 9.440797e-01 9.845505e-01 19 10395023 10395038 16 - 2.059 2.061 0.006
ENSG00000105401 E016 271.6809422 7.579671e-05 5.751982e-01 8.097747e-01 19 10395039 10395143 105 - 2.422 2.431 0.033
ENSG00000105401 E017 318.6518983 8.490690e-04 6.531698e-01 8.541792e-01 19 10395228 10395343 116 - 2.491 2.500 0.029
ENSG00000105401 E018 67.7851680 2.164351e-04 1.864021e-25 7.793343e-23 19 10395344 10395434 91 - 1.524 1.957 1.465
ENSG00000105401 E019 221.6855422 5.320547e-04 6.999622e-01 8.776428e-01 19 10395435 10395495 61 - 2.334 2.343 0.027
ENSG00000105401 E020 161.3269791 8.881613e-04 7.070194e-01 8.811693e-01 19 10395496 10395543 48 - 2.196 2.206 0.032
ENSG00000105401 E021 10.4448388 1.287689e-03 4.891609e-01 7.521300e-01 19 10395544 10395696 153 - 1.086 1.025 -0.222
ENSG00000105401 E022 0.2543986 1.598754e-02 3.717360e-01   19 10395697 10395837 141 - 0.000 0.151 11.554
ENSG00000105401 E023 369.1094199 6.662683e-05 7.630807e-01 9.075792e-01 19 10395928 10396203 276 - 2.557 2.562 0.014
ENSG00000105401 E024 2.0855651 1.758550e-02 6.915302e-01 8.736091e-01 19 10400575 10400693 119 - 0.518 0.459 -0.290
ENSG00000105401 E025 105.0108855 4.965116e-03 6.953119e-01 8.756176e-01 19 10403378 10403457 80 - 2.027 2.010 -0.055
ENSG00000105401 E026 61.8501603 2.267615e-03 3.691704e-01 6.574454e-01 19 10403458 10403595 138 - 1.813 1.774 -0.131
ENSG00000105401 E027 0.0000000       19 10419461 10419597 137 -      
ENSG00000105401 E028 0.0000000       19 10420047 10420121 75 -      

Help

Please Click HERE to learn more details about the results from DEXseq.