ENSG00000106049

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265395 ENSG00000106049 No_inf pgKDN_inf HIBADH protein_coding protein_coding 6.243471 8.018207 5.43515 0.301499 0.3304059 -0.5601059 4.6880564 3.351963 5.43515 0.8479547 0.3304059 0.695668 0.80728333 0.42185 1 0.57815 1.380365e-06 1.380365e-06 FALSE TRUE
ENST00000428288 ENSG00000106049 No_inf pgKDN_inf HIBADH protein_coding nonsense_mediated_decay 6.243471 8.018207 5.43515 0.301499 0.3304059 -0.5601059 0.9576749 2.873025 0.00000 1.0606968 0.0000000 -8.171439 0.12288333 0.36865 0 -0.36865 6.103549e-02 1.380365e-06 FALSE TRUE
MSTRG.25962.3 ENSG00000106049 No_inf pgKDN_inf HIBADH protein_coding   6.243471 8.018207 5.43515 0.301499 0.3304059 -0.5601059 0.5977397 1.793219 0.00000 1.7932192 0.0000000 -7.494431 0.06983333 0.20950 0 -0.20950 9.208113e-01 1.380365e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000106049 E001 0.6066364 0.0163405896 0.368009601 0.65661737 7 27525442 27525474 33 - 0.280 0.145 -1.183
ENSG00000106049 E002 0.7337727 0.0160023181 0.619006942 0.83528536 7 27525475 27525478 4 - 0.280 0.203 -0.598
ENSG00000106049 E003 35.3050297 0.0006363939 0.011568135 0.08852357 7 27525479 27526372 894 - 1.485 1.582 0.334
ENSG00000106049 E004 7.1708109 0.0023857984 0.554762372 0.79751989 7 27531192 27531253 62 - 0.865 0.922 0.219
ENSG00000106049 E005 5.1673369 0.0030008717 0.687641236 0.87124700 7 27531254 27531348 95 - 0.808 0.761 -0.183
ENSG00000106049 E006 3.5834103 0.1208191773 0.930625956 0.97977210 7 27538341 27538417 77 - 0.635 0.661 0.113
ENSG00000106049 E007 7.5805616 0.0149221492 0.105984603 0.34089775 7 27542967 27543100 134 - 0.808 0.980 0.658
ENSG00000106049 E008 6.9959212 0.0024997233 0.363860696 0.65265529 7 27629371 27629492 122 - 0.946 0.855 -0.345
ENSG00000106049 E009 4.5122962 0.0038334758 0.077167863 0.28415227 7 27632336 27632426 91 - 0.847 0.642 -0.833
ENSG00000106049 E010 0.8467467 0.1306592937 0.128266768 0.37962684 7 27632427 27632441 15 - 0.399 0.145 -1.922
ENSG00000106049 E011 0.8467467 0.1306592937 0.128266768 0.37962684 7 27632442 27632445 4 - 0.399 0.145 -1.922
ENSG00000106049 E012 0.0000000       7 27647673 27647756 84 -      
ENSG00000106049 E013 0.0000000       7 27649224 27649472 249 -      
ENSG00000106049 E014 3.0571831 0.0248828280 0.234812038 0.52399158 7 27649473 27649633 161 - 0.692 0.530 -0.714
ENSG00000106049 E015 2.1646538 0.0121221343 0.006107047 0.05721339 7 27662698 27662883 186 - 0.692 0.300 -1.977

Help

Please Click HERE to learn more details about the results from DEXseq.