ENSG00000108854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262435 ENSG00000108854 No_inf pgKDN_inf SMURF2 protein_coding protein_coding 13.563 11.40619 14.69652 0.8257389 0.5744187 0.3653747 4.3207868 4.7391132 4.8762384 0.9036611 0.3476240 0.04106611 0.33109167 0.425100 0.334525 -0.090575 0.84158044 0.04716851 FALSE TRUE
ENST00000578386 ENSG00000108854 No_inf pgKDN_inf SMURF2 protein_coding nonsense_mediated_decay 13.563 11.40619 14.69652 0.8257389 0.5744187 0.3653747 0.8373514 0.5538409 0.8717613 0.5538409 0.5147319 0.64510001 0.06248333 0.052975 0.063525 0.010550 0.84141974 0.04716851 FALSE TRUE
ENST00000580072 ENSG00000108854 No_inf pgKDN_inf SMURF2 protein_coding retained_intron 13.563 11.40619 14.69652 0.8257389 0.5744187 0.3653747 1.0263445 1.5065779 0.0000000 0.6654014 0.0000000 -7.24467583 0.07295000 0.122225 0.000000 -0.122225 0.04716851 0.04716851 FALSE FALSE
ENST00000582081 ENSG00000108854 No_inf pgKDN_inf SMURF2 protein_coding nonsense_mediated_decay 13.563 11.40619 14.69652 0.8257389 0.5744187 0.3653747 0.3316237 0.9948711 0.0000000 0.3957355 0.0000000 -6.65086670 0.03013333 0.090400 0.000000 -0.090400 0.07510673 0.04716851 FALSE TRUE
ENST00000585301 ENSG00000108854 No_inf pgKDN_inf SMURF2 protein_coding protein_coding 13.563 11.40619 14.69652 0.8257389 0.5744187 0.3653747 0.3840020 0.0000000 1.1520061 0.0000000 0.7305814 6.86047386 0.02491667 0.000000 0.074750 0.074750 0.51588009 0.04716851 FALSE TRUE
MSTRG.13171.3 ENSG00000108854 No_inf pgKDN_inf SMURF2 protein_coding   13.563 11.40619 14.69652 0.8257389 0.5744187 0.3653747 5.9729253 2.9946592 7.4689574 1.0488708 0.6886077 1.31563579 0.43107500 0.258850 0.506600 0.247750 0.50193426 0.04716851 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000108854 E001 0.0000000       17 64542282 64542294 13 -      
ENSG00000108854 E002 59.2847931 0.0007481093 9.592109e-07 4.494707e-05 17 64542295 64544803 2509 - 1.685 1.866 0.611
ENSG00000108854 E003 6.2130996 0.0022797430 4.246847e-04 7.683644e-03 17 64544804 64545067 264 - 0.637 1.018 1.496
ENSG00000108854 E004 45.8455041 0.0003946651 9.106782e-03 7.559876e-02 17 64545068 64545947 880 - 1.616 1.724 0.367
ENSG00000108854 E005 19.5818988 0.0008113418 2.166970e-01 5.028271e-01 17 64546263 64546338 76 - 1.274 1.353 0.274
ENSG00000108854 E006 27.9253890 0.0005047588 8.401213e-01 9.425882e-01 17 64547600 64547801 202 - 1.466 1.454 -0.042
ENSG00000108854 E007 17.2553965 0.0009712149 2.216847e-01 5.089321e-01 17 64551584 64551704 121 - 1.299 1.213 -0.302
ENSG00000108854 E008 7.0159880 0.0357507571 1.655236e-01 4.352682e-01 17 64554856 64554880 25 - 0.976 0.805 -0.651
ENSG00000108854 E009 16.5132534 0.0008968550 1.397890e-01 3.976541e-01 17 64554881 64554993 113 - 1.289 1.184 -0.373
ENSG00000108854 E010 23.0388041 0.0006482287 1.773682e-02 1.172038e-01 17 64555820 64555998 179 - 1.443 1.298 -0.504
ENSG00000108854 E011 9.5592996 0.0471331978 1.029563e-01 3.353917e-01 17 64557608 64557640 33 - 1.107 0.903 -0.753
ENSG00000108854 E012 15.5161731 0.0057624958 6.751266e-02 2.621544e-01 17 64557641 64557722 82 - 1.279 1.135 -0.511
ENSG00000108854 E013 0.0000000       17 64560840 64560958 119 -      
ENSG00000108854 E014 16.1575129 0.0009696220 2.115454e-01 4.965398e-01 17 64561500 64561603 104 - 1.274 1.184 -0.320
ENSG00000108854 E015 18.0325754 0.0009669574 6.337025e-01 8.433625e-01 17 64562771 64562966 196 - 1.294 1.261 -0.118
ENSG00000108854 E016 0.8807964 0.0124522322 2.737186e-02 1.540352e-01 17 64562967 64563165 199 - 0.087 0.417 2.859
ENSG00000108854 E017 12.9531365 0.0230698206 6.973617e-01 8.765059e-01 17 64571798 64571956 159 - 1.129 1.160 0.111
ENSG00000108854 E018 7.5509700 0.0096330413 6.349122e-01 8.440054e-01 17 64578492 64578576 85 - 0.955 0.903 -0.195
ENSG00000108854 E019 16.9610851 0.0008619348 8.887573e-01 9.628828e-01 17 64580789 64580991 203 - 1.259 1.248 -0.038
ENSG00000108854 E020 10.7249358 0.0034480460 5.591943e-01 8.005013e-01 17 64583461 64583544 84 - 1.092 1.040 -0.189
ENSG00000108854 E021 12.0895714 0.0163704053 9.039026e-01 9.690691e-01 17 64586086 64586170 85 - 1.122 1.109 -0.048
ENSG00000108854 E022 9.6414439 0.0015905846 8.733563e-01 9.568457e-01 17 64591084 64591149 66 - 1.033 1.018 -0.056
ENSG00000108854 E023 0.1265070 0.0123708424 4.427293e-01   17 64593015 64593439 425 - 0.000 0.104 10.097
ENSG00000108854 E024 8.8265152 0.0022737934 3.379642e-02 1.749787e-01 17 64593440 64593573 134 - 1.076 0.873 -0.756
ENSG00000108854 E025 0.8627992 0.0147240905 5.318770e-01 7.823639e-01 17 64593991 64594104 114 - 0.222 0.317 0.689
ENSG00000108854 E026 5.5624335 0.0068673857 8.974739e-02 3.112381e-01 17 64598382 64598490 109 - 0.898 0.702 -0.773
ENSG00000108854 E027 2.1886647 0.0405656913 5.950499e-01 8.219598e-01 17 64606602 64606640 39 - 0.538 0.460 -0.378
ENSG00000108854 E028 0.1176306 0.0117719377 6.513212e-01   17 64626646 64626685 40 - 0.087 0.000 -9.813
ENSG00000108854 E029 0.1272623 0.0123664921 4.428093e-01   17 64660747 64660862 116 - 0.000 0.104 10.097
ENSG00000108854 E030 9.9325194 0.0058141763 5.100655e-02 2.235484e-01 17 64661829 64662312 484 - 1.115 0.931 -0.674

Help

Please Click HERE to learn more details about the results from DEXseq.