ENSG00000108984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359094 ENSG00000108984 No_inf pgKDN_inf MAP2K6 protein_coding nonsense_mediated_decay 2.978564 0.3379366 4.045647 0.1805795 0.6437952 3.543036 0.15309067 0.04659398 0.3058264 0.04659398 0.1076027 2.480411 0.1259833 0.2500 0.088575 -0.161425 0.88759141 0.03103291 FALSE TRUE
ENST00000590474 ENSG00000108984 No_inf pgKDN_inf MAP2K6 protein_coding protein_coding 2.978564 0.3379366 4.045647 0.1805795 0.6437952 3.543036 0.03499695 0.10499084 0.0000000 0.03539542 0.0000000 -3.523447 0.1793000 0.5379 0.000000 -0.537900 0.03103291 0.03103291 FALSE TRUE
MSTRG.13223.9 ENSG00000108984 No_inf pgKDN_inf MAP2K6 protein_coding   2.978564 0.3379366 4.045647 0.1805795 0.6437952 3.543036 2.61766848 0.18635174 3.5850509 0.18635174 0.5838737 4.194500 0.6607000 0.2121 0.885175 0.673075 0.33332984 0.03103291 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000108984 E001 0.0000000       17 69414697 69414710 14 +      
ENSG00000108984 E002 0.1271363 0.012665395 0.0960745221   17 69414711 69414833 123 + 0.000 0.172 11.691
ENSG00000108984 E003 0.5070043 0.018620339 0.0006361917 0.01050915 17 69414834 69415000 167 + 0.000 0.469 15.398
ENSG00000108984 E004 0.0000000       17 69502154 69502265 112 +      
ENSG00000108984 E005 0.0000000       17 69502266 69502417 152 +      
ENSG00000108984 E006 0.0000000       17 69502429 69502684 256 +      
ENSG00000108984 E007 0.0000000       17 69502685 69502685 1 +      
ENSG00000108984 E008 0.0000000       17 69504459 69504579 121 +      
ENSG00000108984 E009 0.1187032 0.012141701 1.0000000000   17 69505448 69505779 332 + 0.050 0.000 -11.672
ENSG00000108984 E010 0.2533610 0.017726831 0.0197632169   17 69505780 69505846 67 + 0.000 0.295 14.635
ENSG00000108984 E011 0.2374063 0.089403179 1.0000000000   17 69516855 69516903 49 + 0.096 0.000 -12.417
ENSG00000108984 E012 0.4729183 0.022030758 0.5585798622   17 69517252 69517297 46 + 0.174 0.000 -13.129
ENSG00000108984 E013 0.4731135 0.019971115 0.5635659014   17 69517500 69517551 52 + 0.174 0.000 -13.129
ENSG00000108984 E014 0.5917516 0.016796183 0.3919995177 0.67704557 17 69517552 69517613 62 + 0.208 0.000 -13.337
ENSG00000108984 E015 1.8888460 0.008824278 0.0167840772 0.11298458 17 69519313 69519432 120 + 0.473 0.000 -14.313
ENSG00000108984 E016 0.0000000       17 69519433 69520269 837 +      
ENSG00000108984 E017 1.5518780 0.029156356 0.6770379449 0.86610234 17 69520270 69520295 26 + 0.372 0.295 -0.479
ENSG00000108984 E018 1.7926826 0.009774383 0.5114889410 0.76866573 17 69520296 69520386 91 + 0.415 0.295 -0.721
ENSG00000108984 E019 0.0000000       17 69520387 69521048 662 +      
ENSG00000108984 E020 0.9545585 0.218253261 0.7373645030 0.89587765 17 69521049 69521100 52 + 0.270 0.172 -0.828
ENSG00000108984 E021 0.0000000       17 69521101 69521833 733 +      
ENSG00000108984 E022 2.1554205 0.007923261 0.7373026340 0.89586003 17 69523514 69523641 128 + 0.455 0.391 -0.342
ENSG00000108984 E023 1.9187397 0.009414089 0.9247733678 0.97715075 17 69524901 69524978 78 + 0.415 0.391 -0.136
ENSG00000108984 E024 2.0250539 0.007649018 0.3728687470 0.66058874 17 69526570 69526709 140 + 0.455 0.295 -0.927
ENSG00000108984 E025 0.0000000       17 69536066 69536114 49 +      
ENSG00000108984 E026 0.4714143 0.050908837 0.5675931898   17 69536115 69536160 46 + 0.174 0.000 -13.123
ENSG00000108984 E027 13.7047843 0.004848948 0.0806545244 0.29184979 17 69541676 69553865 12190 + 1.064 1.165 0.361

Help

Please Click HERE to learn more details about the results from DEXseq.