ENSG00000110108

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000227525 ENSG00000110108 No_inf pgKDN_inf TMEM109 protein_coding protein_coding 60.14807 48.30756 67.45395 2.481664 5.262911 0.4815692 41.856374 26.341145 51.27102 3.714933 1.298309 0.9605594 0.6988083 0.56150 0.7786 0.21710 0.79463307 0.00474125 FALSE TRUE
ENST00000540280 ENSG00000110108 No_inf pgKDN_inf TMEM109 protein_coding protein_coding_CDS_not_defined 60.14807 48.30756 67.45395 2.481664 5.262911 0.4815692 14.070834 13.957380 16.18293 3.452674 6.135991 0.2133027 0.2262167 0.27945 0.2214 -0.05805 0.85622004 0.00474125   FALSE
MSTRG.4799.1 ENSG00000110108 No_inf pgKDN_inf TMEM109 protein_coding   60.14807 48.30756 67.45395 2.481664 5.262911 0.4815692 4.220859 8.009038 0.00000 2.980891 0.000000 -9.6472854 0.0749750 0.15905 0.0000 -0.15905 0.00474125 0.00474125 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000110108 E001 20.6682649 7.323902e-04 0.603590533 0.82704582 11 60914158 60914268 111 + 1.346 1.316 -0.107
ENSG00000110108 E002 0.1186381 1.174481e-02 0.725695266   11 60919678 60919685 8 + 0.083 0.000 -8.812
ENSG00000110108 E003 60.8625675 2.642891e-04 0.796862643 0.92322542 11 60919686 60919930 245 + 1.792 1.785 -0.023
ENSG00000110108 E004 30.7921382 4.639357e-04 0.732641249 0.89372522 11 60920886 60920988 103 + 1.506 1.491 -0.052
ENSG00000110108 E005 222.9818772 9.506291e-05 0.447834118 0.72199095 11 60921774 60922617 844 + 2.341 2.356 0.049
ENSG00000110108 E006 19.1031884 7.706633e-04 0.012717194 0.09386741 11 60922618 60922641 24 + 1.366 1.200 -0.585
ENSG00000110108 E007 22.6054544 1.018883e-03 0.008550638 0.07228829 11 60922642 60922743 102 + 1.435 1.272 -0.569
ENSG00000110108 E008 161.0312998 2.093662e-03 0.105555129 0.33988121 11 60922744 60923443 700 + 2.188 2.230 0.140

Help

Please Click HERE to learn more details about the results from DEXseq.