ENSG00000115446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357765 ENSG00000115446 No_inf pgKDN_inf UNC50 protein_coding protein_coding 58.82303 48.38795 65.72059 1.084523 2.275764 0.4416191 48.042819 33.573169 54.156039 3.568999 4.050880 0.6896502 0.80885833 0.69430 0.828725 0.134425 5.232949e-01 6.919165e-08 FALSE TRUE
ENST00000466492 ENSG00000115446 No_inf pgKDN_inf UNC50 protein_coding retained_intron 58.82303 48.38795 65.72059 1.084523 2.275764 0.4416191 1.881671 5.178639 0.000000 1.249141 0.000000 -9.0192124 0.03763333 0.10585 0.000000 -0.105850 6.919165e-08 6.919165e-08   FALSE
MSTRG.16722.2 ENSG00000115446 No_inf pgKDN_inf UNC50 protein_coding   58.82303 48.38795 65.72059 1.084523 2.275764 0.4416191 4.733663 3.902884 9.025849 3.902884 5.224917 1.2074277 0.07769167 0.08020 0.132175 0.051975 8.495402e-01 6.919165e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000115446 E001 0.1170040 0.0116660339 0.689551061   2 98608491 98608536 46 + 0.085 0.000 -8.291
ENSG00000115446 E002 0.4812643 0.0186077569 0.456460706   2 98608575 98608578 4 + 0.216 0.107 -1.214
ENSG00000115446 E003 0.9809991 0.0134809464 0.723431673 0.88893282 2 98608579 98608580 2 + 0.270 0.325 0.371
ENSG00000115446 E004 1.8349803 0.0088674576 0.821241246 0.93507208 2 98608581 98608588 8 + 0.435 0.470 0.178
ENSG00000115446 E005 18.0404629 0.0007963560 0.901403516 0.96820248 2 98608589 98608726 138 + 1.281 1.274 -0.021
ENSG00000115446 E006 1.2607941 0.0105724276 0.002293814 0.02829054 2 98608727 98608843 117 + 0.085 0.545 3.541
ENSG00000115446 E007 1.5074498 0.0100662293 0.005136957 0.05058904 2 98608844 98609011 168 + 0.155 0.578 2.693
ENSG00000115446 E008 4.9278841 0.0038363668 0.084263922 0.29974214 2 98609012 98609642 631 + 0.668 0.869 0.807
ENSG00000115446 E009 2.4494754 0.0118471716 0.584579553 0.81539074 2 98609643 98609755 113 + 0.499 0.578 0.371
ENSG00000115446 E010 10.0062112 0.0204843231 0.953819953 0.98861305 2 98609756 98609759 4 + 1.038 1.042 0.017
ENSG00000115446 E011 79.7284087 0.0002267030 0.148701980 0.41073189 2 98609760 98610039 280 + 1.924 1.882 -0.141
ENSG00000115446 E012 57.7279831 0.0003259078 0.039173463 0.19165290 2 98610775 98610895 121 + 1.799 1.725 -0.252
ENSG00000115446 E013 0.7455093 0.0140696454 0.262399973 0.55523089 2 98616206 98616206 1 + 0.155 0.325 1.371
ENSG00000115446 E014 69.5144793 0.0002322575 0.277567076 0.57076993 2 98616207 98616346 140 + 1.861 1.828 -0.114
ENSG00000115446 E015 2.2467634 0.0066187114 0.003563793 0.03922645 2 98616397 98616431 35 + 0.270 0.690 2.178
ENSG00000115446 E016 55.5220110 0.0009197357 0.559616088 0.80061365 2 98616432 98616533 102 + 1.739 1.764 0.085
ENSG00000115446 E017 1.3419497 0.0092712638 0.909568248 0.97128913 2 98618146 98618167 22 + 0.360 0.379 0.108
ENSG00000115446 E018 68.4308203 0.0017655670 0.086321287 0.30441905 2 98618168 98618515 348 + 1.810 1.874 0.216

Help

Please Click HERE to learn more details about the results from DEXseq.