ENSG00000116406

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000439962 ENSG00000116406 No_inf pgKDN_inf EDEM3 protein_coding nonsense_mediated_decay 39.68736 29.8533 45.65971 0.7353113 0.7638884 0.612864 10.327835 9.656212 11.4451664 0.840010 1.1342317 0.2449759 0.26612500 0.322100 0.249775 -0.072325 0.723294041 0.000557898 TRUE TRUE
ENST00000466392 ENSG00000116406 No_inf pgKDN_inf EDEM3 protein_coding retained_intron 39.68736 29.8533 45.65971 0.7353113 0.7638884 0.612864 4.033248 7.829127 0.5172249 1.039487 0.5172249 -3.8942027 0.11966667 0.261925 0.010900 -0.251025 0.000557898 0.000557898 FALSE TRUE
MSTRG.2388.4 ENSG00000116406 No_inf pgKDN_inf EDEM3 protein_coding   39.68736 29.8533 45.65971 0.7353113 0.7638884 0.612864 2.434317 0.000000 0.0000000 0.000000 0.0000000 0.0000000 0.05601667 0.000000 0.000000 0.000000   0.000557898 FALSE TRUE
MSTRG.2388.7 ENSG00000116406 No_inf pgKDN_inf EDEM3 protein_coding   39.68736 29.8533 45.65971 0.7353113 0.7638884 0.612864 13.915485 6.942460 20.2161325 1.073375 1.7903443 1.5406250 0.33753333 0.234850 0.443200 0.208350 0.124750380 0.000557898 TRUE TRUE
MSTRG.2388.9 ENSG00000116406 No_inf pgKDN_inf EDEM3 protein_coding   39.68736 29.8533 45.65971 0.7353113 0.7638884 0.612864 6.018834 2.176076 11.2095723 1.258215 0.8877165 2.3596022 0.14223333 0.072875 0.246375 0.173500 0.252826411 0.000557898 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000116406 E001 0.0000000       1 184690237 184690492 256 -      
ENSG00000116406 E002 0.0000000       1 184690493 184690502 10 -      
ENSG00000116406 E003 0.0000000       1 184690503 184690503 1 -      
ENSG00000116406 E004 2.5714832 0.0057570985 4.345430e-01 0.7117748899 1 184690504 184690517 14 - 0.500 0.607 0.497
ENSG00000116406 E005 2.5714832 0.0057570985 4.345430e-01 0.7117748899 1 184690518 184690518 1 - 0.500 0.607 0.497
ENSG00000116406 E006 3.8144912 0.0040394784 8.094683e-02 0.2923412431 1 184690519 184690539 21 - 0.574 0.791 0.914
ENSG00000116406 E007 6.4618126 0.0026002229 5.299829e-01 0.7812177321 1 184690540 184690570 31 - 0.838 0.904 0.251
ENSG00000116406 E008 33.1773395 0.0004214054 8.753046e-01 0.9574437217 1 184690571 184690668 98 - 1.524 1.531 0.023
ENSG00000116406 E009 65.1889485 0.0002571677 4.158496e-02 0.1982134464 1 184690669 184690820 152 - 1.782 1.856 0.249
ENSG00000116406 E010 181.6220171 0.0001212661 2.816936e-04 0.0055146507 1 184690821 184691353 533 - 2.222 2.297 0.252
ENSG00000116406 E011 16.9509330 0.0123869824 2.663116e-01 0.5597671434 1 184691354 184691371 18 - 1.208 1.299 0.322
ENSG00000116406 E012 191.1175039 0.0001175119 1.460199e-02 0.1031761857 1 184691372 184692145 774 - 2.256 2.305 0.163
ENSG00000116406 E013 231.9356319 0.0001043115 8.913525e-01 0.9638410752 1 184692146 184693365 1220 - 2.360 2.361 0.003
ENSG00000116406 E014 11.1654582 0.0015242270 8.380235e-01 0.9420044160 1 184693366 184693373 8 - 1.086 1.067 -0.070
ENSG00000116406 E015 17.4376884 0.0008076298 3.655564e-01 0.6540639320 1 184693374 184693432 59 - 1.285 1.219 -0.233
ENSG00000116406 E016 87.5472949 0.0001875406 6.453483e-01 0.8498649074 1 184693433 184694043 611 - 1.947 1.930 -0.055
ENSG00000116406 E017 53.6746932 0.0115766363 1.796296e-01 0.4548422867 1 184694044 184694472 429 - 1.763 1.678 -0.289
ENSG00000116406 E018 0.0000000       1 184701497 184701529 33 -      
ENSG00000116406 E019 0.0000000       1 184701530 184701541 12 -      
ENSG00000116406 E020 0.0000000       1 184701542 184701544 3 -      
ENSG00000116406 E021 15.4765141 0.0008953995 9.926629e-02 0.3290282573 1 184702811 184702952 142 - 1.258 1.130 -0.451
ENSG00000116406 E022 7.0282967 0.0022927485 4.738183e-01 0.7407341161 1 184702953 184702996 44 - 0.928 0.851 -0.292
ENSG00000116406 E023 1.1243111 0.0110530670 1.929486e-02 0.1241528291 1 184702997 184703659 663 - 0.144 0.496 2.441
ENSG00000116406 E024 22.5176938 0.0006083140 1.418662e-01 0.4007639135 1 184706643 184706808 166 - 1.401 1.306 -0.331
ENSG00000116406 E025 10.6310070 0.0014905892 1.605108e-01 0.4283731016 1 184708153 184708210 58 - 1.107 0.979 -0.465
ENSG00000116406 E026 19.0829543 0.0008322685 7.931886e-01 0.9211255217 1 184708211 184708344 134 - 1.289 1.306 0.057
ENSG00000116406 E027 10.8314626 0.0012299734 6.363256e-01 0.8448856354 1 184710394 184710450 57 - 1.050 1.089 0.143
ENSG00000116406 E028 12.6676697 0.0011019165 5.071716e-01 0.7656708149 1 184710451 184710547 97 - 1.107 1.159 0.187
ENSG00000116406 E029 1.4683917 0.0090252827 4.503820e-01 0.7237394748 1 184710548 184710550 3 - 0.338 0.452 0.634
ENSG00000116406 E030 17.6060457 0.0008944094 9.573861e-03 0.0781529638 1 184711723 184711877 155 - 1.331 1.140 -0.674
ENSG00000116406 E031 0.7543544 0.0142344090 2.779229e-02 0.1556379728 1 184711878 184712432 555 - 0.078 0.402 2.956
ENSG00000116406 E032 18.1461905 0.0179074764 3.837331e-03 0.0412936913 1 184712433 184712598 166 - 1.365 1.100 -0.938
ENSG00000116406 E033 4.2443765 0.0033611642 1.169107e-05 0.0003914004 1 184713523 184716887 3365 - 0.410 0.951 2.335
ENSG00000116406 E034 12.5197697 0.0011348650 9.639385e-03 0.0784622053 1 184716888 184717012 125 - 1.202 0.979 -0.807
ENSG00000116406 E035 11.4248316 0.0013477074 9.391496e-03 0.0771430019 1 184717540 184717623 84 - 1.169 0.936 -0.851
ENSG00000116406 E036 0.1186381 0.0118656942 8.603468e-01   1 184718838 184719161 324 - 0.078 0.000 -10.313
ENSG00000116406 E037 11.3216543 0.0046235250 2.579714e-02 0.1484099062 1 184719162 184719245 84 - 1.157 0.951 -0.753
ENSG00000116406 E038 0.0000000       1 184719246 184719442 197 -      
ENSG00000116406 E039 13.6128635 0.0101620692 2.028622e-02 0.1280567735 1 184719443 184719568 126 - 1.233 1.019 -0.769
ENSG00000116406 E040 1.1270741 0.3249009837 1.009073e-01 0.3316273091 1 184719569 184720509 941 - 0.144 0.496 2.441
ENSG00000116406 E041 0.3798680 0.0299367035 4.348010e-02   1 184720510 184721288 779 - 0.000 0.282 11.655
ENSG00000116406 E042 11.6791305 0.0117914745 2.292527e-02 0.1381509852 1 184721289 184721386 98 - 1.175 0.951 -0.815
ENSG00000116406 E043 12.3423031 0.0011891339 2.324381e-01 0.5211254951 1 184723751 184723856 106 - 1.157 1.056 -0.366
ENSG00000116406 E044 0.2537694 0.0160228962 1.242406e-01   1 184725055 184726254 1200 - 0.000 0.207 11.204
ENSG00000116406 E045 14.3816145 0.0009442760 3.647000e-01 0.6532804517 1 184726255 184726389 135 - 1.151 1.219 0.240
ENSG00000116406 E046 0.0000000       1 184732783 184732836 54 -      
ENSG00000116406 E047 15.9540739 0.0008560164 1.226767e-01 0.3706899804 1 184732837 184732990 154 - 1.267 1.150 -0.415
ENSG00000116406 E048 0.6246350 0.0149605067 6.516664e-02 0.2570538623 1 184732991 184734339 1349 - 0.078 0.346 2.634
ENSG00000116406 E049 10.5227526 0.0077771548 4.099797e-01 0.6920982145 1 184734531 184734643 113 - 1.086 1.006 -0.292
ENSG00000116406 E050 0.0000000       1 184736950 184737024 75 -      
ENSG00000116406 E051 5.9440910 0.0046888835 9.651537e-01 0.9927074265 1 184737025 184737064 40 - 0.838 0.832 -0.025
ENSG00000116406 E052 7.8710558 0.0079816468 5.605828e-01 0.8011254285 1 184737611 184737711 101 - 0.966 0.904 -0.234
ENSG00000116406 E053 0.0000000       1 184737712 184737736 25 -      
ENSG00000116406 E054 0.4909846 0.0158959278 6.609250e-01   1 184744635 184746749 2115 - 0.144 0.207 0.634
ENSG00000116406 E055 3.7526201 0.0068809213 6.860694e-01 0.8703551971 1 184749547 184749592 46 - 0.693 0.639 -0.228
ENSG00000116406 E056 12.1242186 0.0011914581 1.191183e-03 0.0171105870 1 184754489 184754907 419 - 1.208 0.920 -1.048

Help

Please Click HERE to learn more details about the results from DEXseq.