ENSG00000123374

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266970 ENSG00000123374 No_inf pgKDN_inf CDK2 protein_coding protein_coding 21.71559 22.739 21.87507 1.632875 1.797138 -0.0558563 9.5951073 8.964664 9.970203 0.9822472 2.5145837 0.1532113 0.45147500 0.39840 0.473125 0.074725 0.900446005 0.009339077 FALSE  
ENST00000354056 ENSG00000123374 No_inf pgKDN_inf CDK2 protein_coding protein_coding 21.71559 22.739 21.87507 1.632875 1.797138 -0.0558563 2.6848950 0.000000 3.687387 0.0000000 2.1464416 8.5303621 0.12941667 0.00000 0.176675 0.176675 0.059758971 0.009339077 FALSE  
ENST00000554545 ENSG00000123374 No_inf pgKDN_inf CDK2 protein_coding protein_coding_CDS_not_defined 21.71559 22.739 21.87507 1.632875 1.797138 -0.0558563 3.6025842 6.751698 2.717242 2.5969216 1.6175959 -1.3099431 0.15487500 0.28545 0.115100 -0.170350 0.696357876 0.009339077    
ENST00000555408 ENSG00000123374 No_inf pgKDN_inf CDK2 protein_coding nonsense_mediated_decay 21.71559 22.739 21.87507 1.632875 1.797138 -0.0558563 2.9119272 3.623612 2.165309 0.2785025 0.7802856 -0.7401839 0.13428333 0.16050 0.096825 -0.063675 0.690530992 0.009339077 FALSE  
ENST00000556464 ENSG00000123374 No_inf pgKDN_inf CDK2 protein_coding protein_coding_CDS_not_defined 21.71559 22.739 21.87507 1.632875 1.797138 -0.0558563 1.3714845 1.201951 2.557584 0.8645770 2.1060941 1.0830804 0.05660833 0.05510 0.097925 0.042825 0.979788715 0.009339077    
MSTRG.6623.3 ENSG00000123374 No_inf pgKDN_inf CDK2 protein_coding   21.71559 22.739 21.87507 1.632875 1.797138 -0.0558563 0.9852119 1.552941 0.000000 0.4610548 0.0000000 -7.2881197 0.04670000 0.07390 0.000000 -0.073900 0.009339077 0.009339077 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000123374 E001 0.0000000       12 55966781 55966799 19 +      
ENSG00000123374 E002 0.0000000       12 55966800 55966804 5 +      
ENSG00000123374 E003 0.0000000       12 55966805 55966820 16 +      
ENSG00000123374 E004 0.0000000       12 55966821 55966829 9 +      
ENSG00000123374 E005 0.0000000       12 55966830 55966830 1 +      
ENSG00000123374 E006 0.0000000       12 55966831 55966833 3 +      
ENSG00000123374 E007 0.0000000       12 55966834 55966865 32 +      
ENSG00000123374 E008 0.0000000       12 55966866 55967026 161 +      
ENSG00000123374 E009 0.0000000       12 55967027 55967124 98 +      
ENSG00000123374 E010 0.0000000       12 55967125 55967279 155 +      
ENSG00000123374 E011 0.0000000       12 55967280 55967320 41 +      
ENSG00000123374 E012 0.0000000       12 55967321 55967402 82 +      
ENSG00000123374 E013 0.0000000       12 55967403 55967416 14 +      
ENSG00000123374 E014 0.0000000       12 55967417 55967461 45 +      
ENSG00000123374 E015 3.7638112 0.0039173508 0.001080314 0.01588486 12 55967462 55967856 395 + 0.371 0.815 2.034
ENSG00000123374 E016 7.2113741 0.0022407318 0.235978672 0.52528862 12 55967857 55967934 78 + 0.972 0.858 -0.434
ENSG00000123374 E017 16.9465232 0.0475186685 0.101981451 0.33361240 12 55968049 55968169 121 + 1.344 1.162 -0.642
ENSG00000123374 E018 0.0000000       12 55968170 55968311 142 +      
ENSG00000123374 E019 20.1006232 0.0193132276 0.390686109 0.67612657 12 55968778 55968948 171 + 1.360 1.288 -0.253
ENSG00000123374 E020 5.8887141 0.0027699836 0.672047150 0.86410910 12 55969475 55969576 102 + 0.859 0.815 -0.167
ENSG00000123374 E021 0.8882570 0.0121020834 0.009281612 0.07663724 12 55969577 55969883 307 + 0.000 0.407 11.548
ENSG00000123374 E022 0.6158571 0.0162649253 0.828913540 0.93815048 12 55970598 55970741 144 + 0.188 0.221 0.297
ENSG00000123374 E023 1.2145261 0.0155602174 0.344435213 0.63571175 12 55971044 55971119 76 + 0.419 0.276 -0.872
ENSG00000123374 E024 18.6048124 0.0008105998 0.418996541 0.69874646 12 55971120 55971247 128 + 1.256 1.312 0.195
ENSG00000123374 E025 1.3886821 0.0099804215 0.009793763 0.07924045 12 55971248 55971520 273 + 0.104 0.507 3.034
ENSG00000123374 E026 110.1944841 0.0165531739 0.588057352 0.81718468 12 55971521 55972789 1269 + 2.029 2.052 0.075

Help

Please Click HERE to learn more details about the results from DEXseq.