ENSG00000124422

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261497 ENSG00000124422 No_inf pgKDN_inf USP22 protein_coding protein_coding 38.21829 36.57174 39.99007 1.306585 0.5324653 0.1288786 6.652165 0.000000 13.76103 0.0000000 3.0626679 10.4274204 0.17120833 0.000000 0.345425 0.345425 9.413597e-13 9.413597e-13 FALSE TRUE
ENST00000463692 ENSG00000124422 No_inf pgKDN_inf USP22 protein_coding retained_intron 38.21829 36.57174 39.99007 1.306585 0.5324653 0.1288786 1.374139 2.260995 0.00000 1.0263721 0.0000000 -7.8271808 0.03544167 0.060225 0.000000 -0.060225 4.349276e-02 9.413597e-13 FALSE FALSE
ENST00000537526 ENSG00000124422 No_inf pgKDN_inf USP22 protein_coding protein_coding 38.21829 36.57174 39.99007 1.306585 0.5324653 0.1288786 18.810550 19.012433 16.12697 0.7995241 2.2293846 -0.2373324 0.49417500 0.523825 0.402525 -0.121300 5.775226e-01 9.413597e-13 FALSE TRUE
MSTRG.12288.1 ENSG00000124422 No_inf pgKDN_inf USP22 protein_coding   38.21829 36.57174 39.99007 1.306585 0.5324653 0.1288786 10.186215 13.297078 9.09543 1.2435728 0.8836651 -0.5473948 0.26774167 0.361925 0.227225 -0.134700 2.955271e-01 9.413597e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000124422 E001 8.2802282 0.0017193355 4.635988e-10 4.216482e-08 17 20999384 20999595 212 - 0.542 1.193 2.555
ENSG00000124422 E002 1.6224978 0.0084429808 2.459722e-02 1.440420e-01 17 20999596 20999596 1 - 0.225 0.563 1.970
ENSG00000124422 E003 325.3791634 0.0003453978 3.303626e-03 3.715908e-02 17 20999597 21002374 2778 - 2.493 2.534 0.135
ENSG00000124422 E004 80.8776065 0.0002101598 7.888625e-01 9.189638e-01 17 21002375 21002842 468 - 1.908 1.918 0.032
ENSG00000124422 E005 22.4337980 0.0133637217 5.685251e-01 8.059437e-01 17 21002843 21002971 129 - 1.389 1.347 -0.146
ENSG00000124422 E006 18.6641066 0.0008731758 6.945096e-01 8.752285e-01 17 21002972 21003073 102 - 1.305 1.280 -0.089
ENSG00000124422 E007 10.1916250 0.0013786691 1.449573e-01 4.053154e-01 17 21004202 21004219 18 - 1.105 0.977 -0.468
ENSG00000124422 E008 23.0029219 0.0005853463 1.558107e-03 2.105083e-02 17 21004220 21004351 132 - 1.462 1.267 -0.677
ENSG00000124422 E009 15.6951301 0.0149589346 2.710150e-01 5.646870e-01 17 21004928 21004990 63 - 1.265 1.170 -0.334
ENSG00000124422 E010 0.7622843 0.0140180451 5.508661e-03 5.310172e-02 17 21004991 21005150 160 - 0.000 0.414 11.747
ENSG00000124422 E011 0.8533248 0.0136455482 8.669704e-01 9.541716e-01 17 21006508 21006895 388 - 0.279 0.254 -0.182
ENSG00000124422 E012 20.0672028 0.0008109342 5.836391e-01 8.147532e-01 17 21006896 21006987 92 - 1.305 1.342 0.127
ENSG00000124422 E013 26.3893965 0.0010957752 8.313415e-01 9.391051e-01 17 21007870 21007996 127 - 1.431 1.444 0.045
ENSG00000124422 E014 17.3618228 0.0008095105 6.582497e-01 8.571648e-01 17 21011151 21011229 79 - 1.248 1.280 0.111
ENSG00000124422 E015 13.6761942 0.0340765243 8.634822e-01 9.527896e-01 17 21011230 21011309 80 - 1.156 1.178 0.078
ENSG00000124422 E016 0.4889046 0.0784670012 8.720430e-01   17 21011310 21011614 305 - 0.162 0.185 0.233
ENSG00000124422 E017 21.5668272 0.0008959503 5.006952e-01 7.607328e-01 17 21012830 21012935 106 - 1.373 1.331 -0.144
ENSG00000124422 E018 0.3722815 0.0165932837 4.899629e-01   17 21015651 21015751 101 - 0.088 0.185 1.233
ENSG00000124422 E019 23.1436292 0.0006149640 3.451904e-01 6.362128e-01 17 21015752 21015899 148 - 1.408 1.352 -0.196
ENSG00000124422 E020 13.1454327 0.0010525737 3.639275e-01 6.526553e-01 17 21017942 21017995 54 - 1.183 1.112 -0.253
ENSG00000124422 E021 24.0586856 0.0006044476 8.147028e-02 2.934226e-01 17 21017996 21018111 116 - 1.445 1.342 -0.358
ENSG00000124422 E022 0.0000000       17 21018202 21018341 140 -      
ENSG00000124422 E023 21.8528874 0.0219406334 9.884382e-01 1.000000e+00 17 21019084 21019185 102 - 1.356 1.362 0.023
ENSG00000124422 E024 16.9027418 0.0587960435 3.875668e-01 6.733455e-01 17 21021113 21021205 93 - 1.290 1.207 -0.292
ENSG00000124422 E025 9.5800412 0.0841948819 3.056187e-01 5.989242e-01 17 21021206 21021226 21 - 1.081 0.952 -0.475
ENSG00000124422 E026 18.0314882 0.0011556576 6.089144e-01 8.297992e-01 17 21028542 21028674 133 - 1.295 1.261 -0.120
ENSG00000124422 E027 0.0000000       17 21042220 21042273 54 -      
ENSG00000124422 E028 20.2244802 0.0007497837 3.117459e-03 3.550191e-02 17 21042665 21043035 371 - 1.408 1.215 -0.678
ENSG00000124422 E029 0.3629044 0.0164847033 6.865020e-01   17 21043321 21043625 305 - 0.162 0.102 -0.767
ENSG00000124422 E030 0.0000000       17 21043626 21043760 135 -      

Help

Please Click HERE to learn more details about the results from DEXseq.