ENSG00000125746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

  • Note:

    • About the Coding Potential: Please check the spreadsheet in the “Results” tag to confirm the coding potential. The above figure only show the predicted coding potential. The “gene_biotype” in the result spreadsheet is from the database record. Therefore, if you find conflicts between “gene_biotype” and “codingPotential”, please trust the “gene_biotype”.

    • Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

    • For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245925 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding protein_coding 32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 5.1895905 1.2417564 9.733750 1.2417564 0.9609298 2.960523 0.18310833 0.037025 0.393900 0.356875 0.004347095 0.004347095 FALSE TRUE
ENST00000588000 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding retained_intron 32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 2.5936309 3.0132681 1.427121 0.4406058 0.7270855 -1.072927 0.07812500 0.095450 0.053025 -0.042425 0.676870334 0.004347095 FALSE TRUE
ENST00000588272 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding protein_coding 32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 0.9438913 2.8316738 0.000000 2.8316738 0.0000000 -8.150597 0.02382500 0.071475 0.000000 -0.071475 0.868061215 0.004347095 FALSE FALSE
ENST00000588496 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding protein_coding 32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 0.5874137 0.2402073 1.172525 0.2402073 0.9084586 2.240676 0.02408333 0.006050 0.057550 0.051500 0.807802281 0.004347095 FALSE FALSE
ENST00000592433 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding retained_intron 32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 3.5458257 4.9180899 1.280454 1.2042772 0.7890727 -1.933150 0.10263333 0.148575 0.044775 -0.103800 0.307042927 0.004347095 FALSE FALSE
ENST00000592482 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding retained_intron 32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 4.2474130 4.6032153 2.614788 0.7525654 1.1761975 -0.813572 0.12808333 0.150300 0.092925 -0.057375 0.799133469 0.004347095   FALSE
MSTRG.15336.7 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding   32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 3.0790481 4.0164932 1.874312 0.1296246 0.1730208 -1.095486 0.09615833 0.127750 0.075400 -0.052350 0.627070996 0.004347095 FALSE FALSE
MSTRG.15336.9 ENSG00000125746 No_inf pgKDN_inf EML2 protein_coding   32.2319 32.1819 25.50379 3.16541 2.196256 -0.3354203 7.1996391 7.8705533 1.309427 0.9253375 0.8820472 -2.578386 0.20825000 0.256375 0.051050 -0.205325 0.127519571 0.004347095 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

Help

Please Click HERE to learn more details about the results of IsoformSwitchAnalyzeR.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand pgKDN.inf No.inf log2fold_No.inf_pgKDN.inf
ENSG00000125746 E001 0.2441403 0.0169555701 9.903731e-01   19 45606994 45607506 513 - 0.096 0.095 -0.016
ENSG00000125746 E002 0.0000000       19 45609400 45609401 2 -      
ENSG00000125746 E003 0.0000000       19 45609402 45609451 50 -      
ENSG00000125746 E004 2.2572365 0.0793856812 1.117412e-03 0.016335382 19 45609452 45609566 115 - 0.715 0.172 -3.103
ENSG00000125746 E005 9.4435860 0.0188254902 8.318714e-01 0.939278313 19 45609567 45609661 95 - 1.005 1.031 0.096
ENSG00000125746 E006 10.8387472 0.0025903211 1.598009e-01 0.427345450 19 45609662 45609719 58 - 1.005 1.127 0.446
ENSG00000125746 E007 13.9932559 0.0010344268 5.011017e-01 0.761178861 19 45609720 45609788 69 - 1.148 1.200 0.186
ENSG00000125746 E008 20.3453004 0.0007552553 9.523835e-01 0.988203922 19 45613541 45613671 131 - 1.326 1.331 0.018
ENSG00000125746 E009 13.7470647 0.0213229911 7.228428e-01 0.888603311 19 45614605 45614700 96 - 1.148 1.186 0.138
ENSG00000125746 E010 0.2541163 0.0159857545 2.486710e-01   19 45614826 45615036 211 - 0.000 0.172 13.395
ENSG00000125746 E011 10.6912377 0.0196322419 4.611247e-01 0.732073650 19 45615802 45615858 57 - 1.025 1.103 0.283
ENSG00000125746 E012 6.3887795 0.0026415126 6.181400e-01 0.834783858 19 45615859 45615889 31 - 0.839 0.893 0.206
ENSG00000125746 E013 5.1383607 0.0066346488 9.580125e-05 0.002290312 19 45615890 45616152 263 - 0.473 0.956 2.028
ENSG00000125746 E014 5.2498380 0.0032401827 6.148551e-01 0.832703811 19 45616461 45616484 24 - 0.824 0.768 -0.218
ENSG00000125746 E015 4.5959297 0.0182283860 6.417882e-02 0.255097686 19 45616485 45616495 11 - 0.855 0.619 -0.960
ENSG00000125746 E016 4.8669472 0.0090805077 3.395377e-01 0.631194555 19 45616496 45616499 4 - 0.824 0.711 -0.452
ENSG00000125746 E017 7.5620057 0.0244614565 5.145337e-01 0.771085758 19 45616500 45616517 18 - 0.972 0.893 -0.296
ENSG00000125746 E018 9.2695006 0.0043967190 3.425884e-01 0.634025169 19 45616518 45616558 41 - 1.055 0.967 -0.321
ENSG00000125746 E019 13.4614159 0.0223077936 8.218952e-01 0.935407240 19 45616765 45616853 89 - 1.170 1.151 -0.069
ENSG00000125746 E020 7.9013487 0.0017606287 9.395954e-02 0.318918425 19 45617630 45617676 47 - 1.025 0.865 -0.601
ENSG00000125746 E021 5.1058674 0.0029572024 2.009780e-01 0.483108681 19 45617677 45617697 21 - 0.855 0.711 -0.573
ENSG00000125746 E022 0.3724111 0.1699839301 6.322184e-01   19 45618822 45618943 122 - 0.096 0.172 0.983
ENSG00000125746 E023 15.5464524 0.0018103011 8.602935e-01 0.951579205 19 45619060 45619191 132 - 1.224 1.213 -0.039
ENSG00000125746 E024 6.4548354 0.0232696426 2.589311e-02 0.148771623 19 45619192 45619494 303 - 0.715 0.979 1.025
ENSG00000125746 E025 13.0174053 0.0013704822 7.420057e-04 0.011899892 19 45619645 45620498 854 - 0.983 1.256 0.984
ENSG00000125746 E026 4.8615718 0.0032313325 2.361298e-03 0.028898612 19 45620812 45621162 351 - 0.539 0.906 1.520
ENSG00000125746 E027 1.9755179 0.0086384505 3.354366e-01 0.627288178 19 45621163 45621206 44 - 0.394 0.536 0.721
ENSG00000125746 E028 16.2353505 0.0010264014 2.922361e-01 0.585666712 19 45621207 45621332 126 - 1.272 1.200 -0.256
ENSG00000125746 E029 9.3882593 0.0312386253 3.379963e-01 0.629797712 19 45621483 45621553 71 - 1.064 0.967 -0.355
ENSG00000125746 E030 10.2023263 0.0052504795 2.881447e-02 0.159066473 19 45621554 45621637 84 - 1.140 0.944 -0.717
ENSG00000125746 E031 0.0000000       19 45623456 45623521 66 -      
ENSG00000125746 E032 5.1066905 0.0028620368 2.007515e-01 0.482834650 19 45624719 45624719 1 - 0.855 0.711 -0.573
ENSG00000125746 E033 11.5600503 0.0047912295 1.165834e-01 0.360169557 19 45624720 45624818 99 - 1.163 1.031 -0.476
ENSG00000125746 E034 15.0296405 0.0009619060 3.655284e-01 0.654063932 19 45626705 45626839 135 - 1.237 1.172 -0.228
ENSG00000125746 E035 0.1268540 0.0123473067 5.478214e-01   19 45628698 45628795 98 - 0.000 0.095 12.395
ENSG00000125746 E036 6.0908020 0.0024094655 2.370424e-01 0.526052035 19 45629951 45629963 13 - 0.911 0.786 -0.482
ENSG00000125746 E037 10.8094089 0.0012699394 5.690719e-01 0.806165263 19 45629964 45630046 83 - 1.045 1.095 0.181
ENSG00000125746 E038 0.7446278 0.0920962175 4.639509e-01 0.733610726 19 45632521 45632860 340 - 0.174 0.295 0.984
ENSG00000125746 E039 7.7598974 0.0018273419 2.831395e-01 0.576737056 19 45632861 45632905 45 - 0.883 0.990 0.399
ENSG00000125746 E040 9.9107055 0.0101265911 5.748361e-01 0.809617134 19 45632906 45632971 66 - 1.064 1.011 -0.195
ENSG00000125746 E041 0.1272623 0.0123178915 5.479407e-01   19 45632972 45633069 98 - 0.000 0.095 12.395
ENSG00000125746 E042 9.5244490 0.0015740838 3.317024e-01 0.623867975 19 45633070 45633107 38 - 1.064 0.979 -0.313
ENSG00000125746 E043 7.5900303 0.0025130611 7.581534e-01 0.905104180 19 45633108 45633139 32 - 0.948 0.919 -0.110
ENSG00000125746 E044 16.1680282 0.0057994177 8.280049e-01 0.937738636 19 45634322 45634471 150 - 1.243 1.226 -0.060
ENSG00000125746 E045 0.2543986 0.0160701797 2.484652e-01   19 45634472 45634496 25 - 0.000 0.172 13.395
ENSG00000125746 E046 13.6353754 0.0010881572 5.540790e-01 0.796983531 19 45638505 45638634 130 - 1.140 1.186 0.166
ENSG00000125746 E047 0.2545247 0.2258589754 3.007078e-01   19 45638635 45638844 210 - 0.000 0.172 13.395
ENSG00000125746 E048 6.5178293 0.0023035901 5.274862e-01 0.779441134 19 45638845 45638873 29 - 0.839 0.906 0.257
ENSG00000125746 E049 0.0000000       19 45638874 45638993 120 -      
ENSG00000125746 E050 0.0000000       19 45638994 45639104 111 -      
ENSG00000125746 E051 0.0000000       19 45639207 45639294 88 -      
ENSG00000125746 E052 0.1176306 0.0116903423 5.292235e-01   19 45639295 45639356 62 - 0.096 0.000 -12.533
ENSG00000125746 E053 4.8116333 0.0032509432 2.857425e-01 0.579369976 19 45639357 45639407 51 - 0.694 0.819 0.507
ENSG00000125746 E054 0.1272623 0.0123178915 5.479407e-01   19 45640024 45640131 108 - 0.000 0.095 12.395
ENSG00000125746 E055 0.3724075 0.0165995718 5.941420e-01   19 45640417 45640929 513 - 0.096 0.172 0.983
ENSG00000125746 E056 0.2346346 0.0157214524 2.367842e-01   19 45640930 45641640 711 - 0.174 0.000 -13.533
ENSG00000125746 E057 0.0000000       19 45641641 45641671 31 -      
ENSG00000125746 E058 0.0000000       19 45641672 45641745 74 -      
ENSG00000125746 E059 0.0000000       19 45641746 45641748 3 -      
ENSG00000125746 E060 0.2539903 0.0161388962 2.483254e-01   19 45641749 45641917 169 - 0.000 0.172 13.395
ENSG00000125746 E061 0.0000000       19 45641918 45642041 124 -      
ENSG00000125746 E062 0.0000000       19 45642042 45642133 92 -      
ENSG00000125746 E063 0.0000000       19 45642134 45642352 219 -      
ENSG00000125746 E064 0.0000000       19 45642353 45642471 119 -      
ENSG00000125746 E065 0.0000000       19 45642472 45642778 307 -      
ENSG00000125746 E066 0.0000000       19 45643579 45643727 149 -      
ENSG00000125746 E067 0.0000000       19 45644709 45644917 209 -      
ENSG00000125746 E068 0.0000000       19 45645273 45645602 330 -      

Help

Please Click HERE to learn more details about the results from DEXseq.